{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:25:04Z","timestamp":1793975104293,"version":"4.8.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018692","name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tumour Virus Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tvr.2026.200347","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:30:41Z","timestamp":1784010641000},"page":"200347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["HTLV-1 HBZ inhibits DHX9 to reprogram circRNA biogenesis in ATLL"],"prefix":"10.1016","volume":"22","author":[{"given":"Julien","family":"Ladet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Bazire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fontrodona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Van den Broeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambroise","family":"Mar\u00e7ais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Shallak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Forlani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto S.","family":"Accolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril F.","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4840-021X","authenticated-orcid":false,"given":"Franck","family":"Mortreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvr.2026.200347_bib1","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2026.200347_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood-2016-09-692574","article-title":"Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells","volume":"129","author":"Watanabe","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.tvr.2026.200347_bib3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fmicb.2012.00322","article-title":"Adult T-cell leukemia: a review of epidemiological evidence","volume":"3","author":"Iwanaga","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.tvr.2026.200347_bib4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the lymphoma study group (1984-87)","volume":"79","author":"Shimoyama","year":"1991","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.tvr.2026.200347_bib5","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1182\/blood-2015-03-632489","article-title":"Treatment and survival among 1594 patients with ATL","volume":"126","author":"Katsuya","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.tvr.2026.200347_bib6","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1182\/blood.V88.12.4646.bloodjournal88124646","article-title":"Adult T-cell leukemia\/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells","volume":"88","author":"Cavrois","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.tvr.2026.200347_bib7","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1038\/leu.2017.260","article-title":"Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality","volume":"31","author":"Artesi","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.tvr.2026.200347_bib8","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1128\/jvi.69.5.2863-2868.1995","article-title":"Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy","volume":"69","author":"Wattel","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2026.200347_bib9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41375-020-0900-3","article-title":"Targeted deep sequencing reveals clonal and subclonal mutational signatures in adult T-cell leukemia\/lymphoma and defines an unfavorable indolent subtype","volume":"35","author":"Marcais","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.tvr.2026.200347_bib10","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tvr.2026.200347_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28424","article-title":"HTLV-1 persistent infection and ATLL oncogenesis","volume":"95","author":"Zuo","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.tvr.2026.200347_bib12","first-page":"2299","article-title":"HTLV-1 persistence and the oncogenesis of adult T-cell leukemia\/lymphoma","volume":"141","author":"Bangham","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.tvr.2026.200347_bib13","first-page":"9","article-title":"Mechanisms of oncogenesis by HTLV-1 tax","author":"Mohanty","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.tvr.2026.200347_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001274","article-title":"HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo","volume":"7","author":"Satou","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tvr.2026.200347_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12977-020-0511-0","article-title":"HTLV-1 bZIP factor: the key viral gene for pathogenesis","volume":"17","author":"Matsuoka","year":"2020","journal-title":"Retrovirology"},{"key":"10.1016\/j.tvr.2026.200347_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.939863","article-title":"The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing","volume":"13","author":"Shallak","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tvr.2026.200347_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009919","article-title":"The HTLV-1 viral oncoproteins tax and HBZ reprogram the cellular mRNA splicing landscape","volume":"17","author":"Vandermeulen","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tvr.2026.200347_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12977-014-0119-3","article-title":"HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia","volume":"11","author":"Thenoz","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.tvr.2026.200347_bib19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells","volume":"103","author":"Satou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2026.200347_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-4690-5-34","article-title":"Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells","volume":"5","author":"Usui","year":"2008","journal-title":"Retrovirology"},{"key":"10.1016\/j.tvr.2026.200347_bib21","article-title":"Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia","volume":"122","author":"Liu","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2026.200347_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/280339a0","article-title":"Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells","volume":"280","author":"Hsu","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.tvr.2026.200347_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing","volume":"56","author":"Ashwal-Fluss","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.tvr.2026.200347_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tvr.2026.200347_bib25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nsmb.2959","article-title":"Exon-intron circular RNAs regulate transcription in the nucleus","volume":"22","author":"Li","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tvr.2026.200347_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/cdd.2016.133","article-title":"Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity","volume":"24","author":"Du","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tvr.2026.200347_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ccell.2019.12.007","article-title":"Epigenetic silencing of CDR1as drives IGF2BP3-Mediated melanoma invasion and metastasis","volume":"37","author":"Hanniford","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tvr.2026.200347_bib28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41419-021-03566-2","article-title":"CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tvr.2026.200347_bib29","article-title":"Mechanism of circADD2 as ceRNA in childhood acute lymphoblastic leukemia","volume":"9","author":"Zhu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tvr.2026.200347_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature21715","article-title":"DHX9 suppresses RNA processing defects originating from the alu invasion of the human genome","volume":"544","author":"Aktas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tvr.2026.200347_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030697","article-title":"Oxaliplatin-induced DHX9 phosphorylation promotes oncogenic circular RNA CCDC66 expression and development of chemoresistance","volume":"12","author":"Lin","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tvr.2026.200347_bib32","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1038\/s41467-023-38747-4","article-title":"Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN","volume":"14","author":"Fuchs","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tvr.2026.200347_bib33","doi-asserted-by":"crossref","first-page":"D52","DOI":"10.1093\/nar\/gkad770","article-title":"circAtlas 3.0: a gateway to 3 million curated vertebrate circular RNAs based on a standardized nomenclature scheme","volume":"52","author":"Wu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tvr.2026.200347_bib34","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3324\/haematol.2020.272468","article-title":"Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia","volume":"106","author":"Forlani","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.tvr.2026.200347_bib35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1261\/rna.078754.121","article-title":"Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA counterpart in terminal hematopoiesis","volume":"28","author":"Nicolet","year":"2022","journal-title":"RNA"},{"key":"10.1016\/j.tvr.2026.200347_bib36","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1038\/s41467-018-05096-6","article-title":"Engineering circular RNA for potent and stable translation in eukaryotic cells","volume":"9","author":"Wesselhoeft","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tvr.2026.200347_bib37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cell.2014.09.001","article-title":"Complementary sequence-mediated exon circularization","volume":"159","author":"Zhang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tvr.2026.200347_bib38","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2017.05.023","article-title":"Coordinated circRNA biogenesis and function with NF90\/NF110 in viral infection","volume":"67","author":"Li","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.tvr.2026.200347_bib39","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.1158\/0008-5472.CAN-13-3564","article-title":"HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs","volume":"74","author":"Vernin","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.tvr.2026.200347_bib40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","article-title":"The emerging roles of circRNAs in cancer and oncology","volume":"19","author":"Kristensen","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.tvr.2026.200347_bib41","doi-asserted-by":"crossref","first-page":"42716","DOI":"10.18632\/oncotarget.8446","article-title":"The biology of DHX9 and its potential as a therapeutic target","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.tvr.2026.200347_bib42","doi-asserted-by":"crossref","first-page":"9011","DOI":"10.1093\/nar\/gky742","article-title":"A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-\u03baB-mediated innate immunity against DNA virus infection","volume":"46","author":"Ng","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tvr.2026.200347_bib43","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1111\/febs.14492","article-title":"NF-kappaB signaling mechanisms in HTLV-1-induced adult T-cell leukemia\/lymphoma","volume":"285","author":"Harhaj","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.tvr.2026.200347_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4161\/rna.23312","article-title":"DEAD box RNA helicase functions in cancer","volume":"10","author":"Fuller-Pace","year":"2013","journal-title":"RNA Biol."},{"key":"10.1016\/j.tvr.2026.200347_bib45","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1093\/nar\/gkz576","article-title":"An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3' ends","volume":"47","author":"Xiao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tvr.2026.200347_bib46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12977-015-0186-0","article-title":"Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL","volume":"12","author":"Raval","year":"2015","journal-title":"Retrovirology"},{"key":"10.1016\/j.tvr.2026.200347_bib47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41467-019-13840-9","article-title":"Accurate quantification of circular RNAs identifies extensive circular isoform switching events","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tvr.2026.200347_bib48","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1101\/gr.202895.115","article-title":"Diverse alternative back-splicing and alternative splicing landscape of circular RNAs","volume":"26","author":"Zhang","year":"2016","journal-title":"Genome Res."},{"key":"10.1016\/j.tvr.2026.200347_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tvr.2026.200347_bib50","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1101\/gr.275348.121","article-title":"Quantifying full-length circular RNAs in cancer","volume":"31","author":"Yu","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.tvr.2026.200347_bib51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tvr.2026.200347_bib52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.tvr.2026.200347_bib53","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.chom.2015.11.002","article-title":"Meta- and orthogonal integration of influenza \"OMICs\" data defines a role for UBR4 in virus budding","volume":"18","author":"Tripathi","year":"2015","journal-title":"Cell Host Microbe"}],"container-title":["Tumour Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266667902600011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266667902600011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:29:50Z","timestamp":1793971790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266667902600011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":53,"alternative-id":["S266667902600011X"],"URL":"https:\/\/doi.org\/10.1016\/j.tvr.2026.200347","relation":{},"ISSN":["2666-6790"],"issn-type":[{"value":"2666-6790","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HTLV-1 HBZ inhibits DHX9 to reprogram circRNA biogenesis in ATLL","name":"articletitle","label":"Article Title"},{"value":"Tumour Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvr.2026.200347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"200347"}}