{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:07:40Z","timestamp":1785521260210,"version":"3.56.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Clinics of North America"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ucl.2019.12.008","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T08:52:42Z","timestamp":1583743962000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Male Infertility and Somatic Health"],"prefix":"10.1016","volume":"47","author":[{"given":"Mujalli Mhailan","family":"Murshidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy T.","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Eisenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ucl.2019.12.008_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/09513590.2017.1391208","article-title":"Infertility and surrogacy first mentioned on a 4000-year-old Assyrian clay tablet of marriage contract in Turkey","volume":"34","author":"Turp","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ucl.2019.12.008_bib2","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009","volume":"92","author":"Zegers-Hochschild","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A\u00a0unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ucl.2019.12.008_bib4","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.fertnstert.2012.11.037","article-title":"Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach","volume":"99","author":"Thoma","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib5","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.fertnstert.2014.12.103","article-title":"Diagnostic evaluation of the infertile male: a committee opinion","volume":"103","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2015","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ucl.2019.12.008_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12020-018-1584-6","article-title":"Klinefelter syndrome, insulin resistance, metabolic syndrome, and diabetes: review of literature and clinical perspectives","volume":"61","author":"Salzano","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.ucl.2019.12.008_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/1055-9965.20.14.1","article-title":"Epidemiology of male breast cancer","volume":"14","author":"Weiss","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ucl.2019.12.008_bib8","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jnci\/dji240","article-title":"Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study","volume":"97","author":"Swerdlow","year":"2005","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ucl.2019.12.008_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1472-6483(10)60801-2","article-title":"Molecular pathology of the CFTR locus in male infertility","volume":"10","author":"Claustres","year":"2005","journal-title":"Reprod BioMed Online"},{"key":"10.1016\/j.ucl.2019.12.008_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.fertnstert.2006.07.1531","article-title":"Abnormal progression through meiosis in men with nonobstructive azoospermia","volume":"87","author":"Sun","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib11","doi-asserted-by":"crossref","first-page":"e989","DOI":"10.1371\/journal.pone.0000989","article-title":"Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss","volume":"2","author":"Paul","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ucl.2019.12.008_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ng0995-64","article-title":"MSH2 deficient mice are viable and susceptible to lymphoid tumours","volume":"11","author":"Reitmair","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.ucl.2019.12.008_bib13","doi-asserted-by":"crossref","first-page":"e0181615","DOI":"10.1371\/journal.pone.0181615","article-title":"Systematic immunohistochemical screening for mismatch repair and ERCC1 gene expression from colorectal cancers in China: clinicopathological characteristics and effects on survival","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ucl.2019.12.008_bib14","first-page":"8053","article-title":"Mismatch repair protein expression in patients with stage II and III sporadic colorectal cancer","volume":"15","author":"Zhao","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ucl.2019.12.008_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.fertnstert.2013.05.022","article-title":"Increased risk of cancer among azoospermic men","volume":"100","author":"Eisenberg","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/humrep\/15.6.1289","article-title":"Increased frequency of mutations in DNA from infertile men with meiotic arrest","volume":"15","author":"Nudell","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ucl.2019.12.008_bib17","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.fertnstert.2009.09.006","article-title":"A\u00a0decade of experience emphasizes that testing for Y microdeletions is essential in American men with azoospermia and severe oligozoospermia","volume":"94","author":"Stahl","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib18","doi-asserted-by":"crossref","first-page":"E674","DOI":"10.1210\/jc.2010-2018","article-title":"Aberrations in pseudoautosomal regions (PARs) found in infertile men with Y-chromosome microdeletions","volume":"96","author":"Jorgez","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ucl.2019.12.008_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/ahg.12286","article-title":"Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility","volume":"83","author":"Garcia Rodriguez","year":"2019","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.ucl.2019.12.008_bib20","first-page":"54","article-title":"Genetic aspects of male infertility: from bench to clinic","volume":"47","author":"Ben Rhouma","year":"2019","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"10.1016\/j.ucl.2019.12.008_bib21","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J\u00a0Am Coll Nutr"},{"key":"10.1016\/j.ucl.2019.12.008_bib22","first-page":"158","article-title":"Fetal origins of adult disease","volume":"41","author":"Calkins","year":"2011","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"10.1016\/j.ucl.2019.12.008_bib23","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ucl.2019.12.008_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility","volume":"96","author":"Skakkebaek","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ucl.2019.12.008_bib25","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.urology.2012.12.003","article-title":"Does infertility treatment increase male reproductive tract disorder?","volume":"81","author":"Bang","year":"2013","journal-title":"Urology"},{"key":"10.1016\/j.ucl.2019.12.008_bib26","doi-asserted-by":"crossref","first-page":"e0168162","DOI":"10.1371\/journal.pone.0168162","article-title":"Former very preterm infants show an unfavorable cardiovascular risk profile at a preschool age","volume":"11","author":"Posod","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ucl.2019.12.008_bib27","doi-asserted-by":"crossref","first-page":"R161","DOI":"10.1530\/JOE-18-0021","article-title":"Impact of prematurity for pancreatic islet and beta cell development","volume":"238","author":"Bloomfield","year":"2018","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.ucl.2019.12.008_bib28","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/humrep\/dew245","article-title":"Semen quality of young adult ICSI offspring: the first results","volume":"31","author":"Belva","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ucl.2019.12.008_bib29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/humrep\/dez005","article-title":"The risk of birth defects is not associated with semen parameters or mode of conception in offspring of men visiting a reproductive health clinic","volume":"34","author":"Pastuszak","year":"2019","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ucl.2019.12.008_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humupd\/dms050","article-title":"BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis","volume":"19","author":"Sermondade","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ucl.2019.12.008_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/1557988318822572","article-title":"The negative impact of higher body mass index on sperm quality and erectile function: a cross-sectional study among Chinese males of infertile couples","volume":"13","author":"Zhang","year":"2019","journal-title":"Am J Mens Health"},{"key":"10.1016\/j.ucl.2019.12.008_bib32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.fertnstert.2010.06.031","article-title":"Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses","volume":"95","author":"Li","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib33","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/humrep\/deu118","article-title":"Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA","volume":"29","author":"Jensen","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ucl.2019.12.008_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/bmj.317.7157.505","article-title":"Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy","volume":"317","author":"Jensen","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.ucl.2019.12.008_bib35","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.eururo.2009.03.001","article-title":"Are infertile men less healthy than fertile men? Results of a prospective case-control survey","volume":"56","author":"Salonia","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.ucl.2019.12.008_bib36","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.fertnstert.2018.07.002","article-title":"Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis","volume":"110","author":"Shiraishi","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib37","doi-asserted-by":"crossref","first-page":"e13165","DOI":"10.1111\/and.13165","article-title":"Schistosomiasis (bilharziasis) and male infertility","volume":"51","author":"Abdel-Naser","year":"2019","journal-title":"Andrologia"},{"key":"10.1016\/j.ucl.2019.12.008_bib38","first-page":"306","article-title":"Significant correlation between high-risk HPV DNA in semen and impairment of sperm quality in infertile men","volume":"12","author":"Moghimi","year":"2019","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.eururo.2007.03.085","article-title":"Semen quality in men with malignant diseases before and after therapy and the role of cryopreservation","volume":"52","author":"Trottmann","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.ucl.2019.12.008_bib40","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/bmj.321.7264.789","article-title":"Risk of testicular cancer in men with abnormal semen characteristics: cohort study","volume":"321","author":"Jacobsen","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ucl.2019.12.008_bib41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archinternmed.2008.562","article-title":"Increased risk of testicular germ cell cancer among infertile men","volume":"169","author":"Walsh","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ucl.2019.12.008_bib42","first-page":"1596","article-title":"Increased risk of cancer in infertile men: analysis of U.S. claims data","volume":"193","author":"Eisenberg","year":"2015","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.ucl.2019.12.008_bib43","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/cncr.25075","article-title":"Increased risk of high-grade prostate cancer among infertile men","volume":"116","author":"Walsh","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.ucl.2019.12.008_bib44","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.fertnstert.2015.10.027","article-title":"Subfertility increases risk of testicular cancer: evidence from population-based semen samples","volume":"105","author":"Hanson","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib45","first-page":"1635","article-title":"Male infertility and prostate cancer risk: a nested case-control study","volume":"21","author":"Ruhayel","year":"2010","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.ucl.2019.12.008_bib46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2017.11.005","article-title":"Male infertility: a biomarker of individual and familial cancer risk","volume":"109","author":"Hanson","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib47","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.fertnstert.2016.05.021","article-title":"Cancer risk in first- and second-degree relatives of men with poor semen quality","volume":"106","author":"Anderson","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib48","first-page":"898","article-title":"Childhood cancer risk in the siblings and cousins of men with poor semen quality","volume":"197","author":"Anderson","year":"2017","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.ucl.2019.12.008_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5534\/wjmh.2017.35.2.59","article-title":"Hypertension and male fertility","volume":"35","author":"Guo","year":"2017","journal-title":"World J Mens Health"},{"key":"10.1016\/j.ucl.2019.12.008_bib50","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1093\/humrep\/der305","article-title":"Fatherhood and the risk of cardiovascular mortality in the NIH-AARP Diet and Health Study","volume":"26","author":"Eisenberg","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ucl.2019.12.008_bib51","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.fertnstert.2015.11.011","article-title":"Increased risk of incident chronic medical conditions in infertile men: analysis of United States claims data","volume":"105","author":"Eisenberg","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ucl.2019.12.008_bib52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/andr.12437","article-title":"The association between varicocoeles and vascular disease: an analysis of U.S. claims data","volume":"6","author":"Wang","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.ucl.2019.12.008_bib53","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.2047-2927.2014.00198.x","article-title":"Lipid concentrations and semen quality: the LIFE study","volume":"2","author":"Schisterman","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.ucl.2019.12.008_bib54","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s11255-009-9565-6","article-title":"Is male fertility associated with type 2 diabetes mellitus?","volume":"41","author":"Bener","year":"2009","journal-title":"Int Urol Nephrol"},{"issue":"14","key":"10.1016\/j.ucl.2019.12.008_bib55","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1177\/1352458517734069","article-title":"Male factor infertility and risk of multiple sclerosis: a register-based cohort study","volume":"24","author":"Glazer","year":"2018","journal-title":"Mult Scler"},{"key":"10.1016\/j.ucl.2019.12.008_bib56","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/andr.12436","article-title":"Increased risk of autoimmune disorders in infertile men: analysis of US claims data","volume":"6","author":"Brubaker","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.ucl.2019.12.008_bib57","first-page":"205","article-title":"Sex-based differences in autoimmune diseases","volume":"52","author":"Ortona","year":"2016","journal-title":"Ann Ist Super Sanita"},{"key":"10.1016\/j.ucl.2019.12.008_bib58","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/aje\/kwx067","article-title":"Semen quality as a predictor of subsequent morbidity: a Danish Cohort Study of 4,712 men with long-term follow-up","volume":"186","author":"Latif","year":"2017","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.ucl.2019.12.008_bib59","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/andr.12477","article-title":"Semen quality associated with subsequent hospitalizations - Can the effect be explained by socio-economic status and lifestyle factors?","volume":"6","author":"Latif","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.ucl.2019.12.008_bib60","first-page":"46","article-title":"Men with subnormal sperm counts live shorter lives","volume":"53","author":"Groos","year":"2006","journal-title":"Soc Biol"},{"key":"10.1016\/j.ucl.2019.12.008_bib61","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/aje\/kwp168","article-title":"Good semen quality and life expectancy: a cohort study of 43,277 men","volume":"170","author":"Jensen","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ucl.2019.12.008_bib62","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/humrep\/deu106","article-title":"Semen quality, infertility and mortality in the USA","volume":"29","author":"Eisenberg","year":"2014","journal-title":"Hum Reprod"}],"container-title":["Urologic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0094014319301156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0094014319301156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:38:07Z","timestamp":1758807487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0094014319301156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0094014319301156"],"URL":"https:\/\/doi.org\/10.1016\/j.ucl.2019.12.008","relation":{},"ISSN":["0094-0143"],"issn-type":[{"value":"0094-0143","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Male Infertility and Somatic Health","name":"articletitle","label":"Article Title"},{"value":"Urologic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ucl.2019.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}