{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:37:59Z","timestamp":1776328679537,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","theclinics.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Clinics of North America"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ucl.2024.03.010","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T13:11:11Z","timestamp":1712668271000},"page":"421-427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regionalization of Testis Cancer Care\u2014Is It Necessary?"],"prefix":"10.1016","volume":"51","author":[{"given":"Axel","family":"Heidenreich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Paffenholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ucl.2024.03.010_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.eururo.2023.04.010","article-title":"European association of urology guidelines on testicular cancer: 2023 Update","volume":"84","author":"Patrikidou","year":"2023","journal-title":"Eur Urol"},{"issue":"1","key":"10.1016\/j.ucl.2024.03.010_bib3","first-page":"20","article-title":"Diagnosis and treatment of early- stage testicular cancer: AUA Guideline Amendment 2023","volume":"211","author":"Stephenson","year":"2024","journal-title":"J\u00a0Urol"},{"issue":"8","key":"10.1016\/j.ucl.2024.03.010_bib4","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/annonc\/mdy217","article-title":"ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up","volume":"29","author":"Honecker","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib5","article-title":"Non- guideline-concordant treatment of testicular cancer is associated with reduced relapse-free survival","volume":"6","author":"Paffenholz","year":"2017","journal-title":"Clin Genitourin Cancer"},{"issue":"3 Pt 1","key":"10.1016\/j.ucl.2024.03.010_bib6","first-page":"684","article-title":"Adherence to national comprehensive cancer network\u00ae guidelines for testicular cancer","volume":"197","author":"Wymer","year":"2017","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.ucl.2024.03.010_bib7","doi-asserted-by":"crossref","first-page":"e785","DOI":"10.1016\/j.clgc.2018.02.014","article-title":"Disparities in access and regionalization of care in testicular cancer","volume":"16","author":"Macleod","year":"2018","journal-title":"Clin Genitourin Cancer"},{"issue":"2","key":"10.1016\/j.ucl.2024.03.010_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.euo.2018.10.006","article-title":"Impact of centralizing care for genitourinary malignancies to high-volume providers: A systematic review","author":"Williams","year":"2019","journal-title":"Eur Urol Oncol"},{"issue":"3","key":"10.1016\/j.ucl.2024.03.010_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/MOU.0000000000000490","article-title":"Relationship of surgeon\/hospital volume with outcomes in uro-oncology surgery","volume":"28","author":"Grande","year":"2018","journal-title":"Curr Opin Urol"},{"issue":"3","key":"10.1016\/j.ucl.2024.03.010_bib10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0302-2838(02)00004-0","article-title":"Accuracy of frozen section examination of testicular tumors of uncertain origin","volume":"41","author":"Elert","year":"2002","journal-title":"Eur Urol"},{"issue":"16","key":"10.1016\/j.ucl.2024.03.010_bib11","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1200\/JCO.18.01480","article-title":"Serum levels of MicroRNA-371a-3p (M371 Test) as a new biomarker of testicular germ cell tumors: results of a prospective multicentric study","volume":"37","author":"Dieckmann","year":"2019","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib12","article-title":"Evaluation of a miRNA-371a-3p assay for predicting final histopathology in patients undergoing primary nerve-sparing retroperitoneal lymphadenectomy for stage IIA\/B Seminoma or Nonseminoma","author":"Seelemeyer","year":"2023","journal-title":"Ur Urol Oncol"},{"issue":"6","key":"10.1016\/j.ucl.2024.03.010_bib13","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/PAS.0000000000001049","article-title":"Intraoperative consultation and macroscopic handling: the international society of urological pathology (isup) testicular cancer consultation conference recommendations","volume":"42","author":"Verrill","year":"2018","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.ucl.2024.03.010_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1200\/JCO.1992.10.1.69","article-title":"Prognosis and other clinical correlates of pathologic review in stage I and II testicular carcinoma: a report from the Testicular Cancer Intergroup Study","volume":"10","author":"Sesterhenn","year":"1992","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"10.1016\/j.ucl.2024.03.010_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/his.12657","article-title":"Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists","volume":"67","author":"Berney","year":"2015","journal-title":"Histopathology"},{"issue":"6","key":"10.1016\/j.ucl.2024.03.010_bib16","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.3892\/or.2014.3153","article-title":"German second-opinion network for testicular cancer: sealing the leaky pipe between evidence and clinical practice","volume":"31","author":"Zengerling","year":"2014","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ucl.2024.03.010_bib17","article-title":"Prognostic factors for relapse in patients with clinical stage I testicular seminoma: a nationwide, population-based cohort study","volume":"8","author":"Wagner","year":"2023","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib18","article-title":"Prognostic factor risk groups for clinical stage i seminoma: an individual patient data analysis by the european association of urology testicular cancer guidelines panel and guidelines office","author":"Boormans","year":"2023","journal-title":"Eur Urol Oncol"},{"issue":"22","key":"10.1016\/j.ucl.2024.03.010_bib19","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1200\/JCO.21.01199","article-title":"Imaging modality and frequency in surveillance of stage I seminoma testicular cancer: results from a randomized, phase III, noninferiority trial (TRISST)","volume":"40","author":"Joffe","year":"2022","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/jnci\/91.10.839","volume":"91","author":"Collette","year":"1999","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.ucl.2024.03.010_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.urolonc.2017.08.024","article-title":"Impact of hospital case volume on testicular cancer outcomes and practice patterns","volume":"36","author":"Woldu","year":"2018","journal-title":"Urol Oncol"},{"issue":"13","key":"10.1016\/j.ucl.2024.03.010_bib22","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S1470-2045(14)70490-5","article-title":"Personalised chemotherapy based on tumour marker decline in poor prognosis germ- cell tumours (GETUG 13): a phase 3, multicentre, randomised trial","volume":"15","author":"Fizazi","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejca.2017.09.029","article-title":"Patterns of relapse in poor-prognosis germ-cell tumours in the GETUG 13 trial: Implications for assessment of brain metastases","volume":"87","author":"Loriot","year":"2017","journal-title":"Eur J Cancer"},{"issue":"6","key":"10.1016\/j.ucl.2024.03.010_bib24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1200\/JCO.19.01180","article-title":"Cardiovascular risk factors and disease after male germ cell cancer","volume":"38","author":"Lauritsen","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"issue":"2","key":"10.1016\/j.ucl.2024.03.010_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/MOU.0000000000000736","article-title":"Role of primary retroperitoneal lymph node dissection in stage I and low-volume metastatic germ cell tumors","volume":"30","author":"Heidenreich","year":"2020","journal-title":"Curr Opin Urol"},{"issue":"7","key":"10.1016\/j.ucl.2024.03.010_bib26","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00345-019-02972-8","article-title":"Centralization tendencies of retroperitoneal lymph node dissection for testicular cancer in Germany? A total population-based analysis from 2006 to 2015","volume":"38","author":"Groeben","year":"2020","journal-title":"World J Urol"},{"key":"10.1016\/j.ucl.2024.03.010_bib27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.urology.2009.01.085","article-title":"Population-based study of perioperative mortality after retroperitoneal lymphadenectomy for non-seminomatous testicular germ cell tumors","volume":"74","author":"Capitanio","year":"2009","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.ucl.2024.03.010_bib28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/annonc\/mdw605","article-title":"Surgical management of complex residual masses following systemic chemotherapy for metastatic testicular germ cell tumours","volume":"28","author":"Heidenreich","year":"2017","journal-title":"Ann Oncol"},{"issue":"12","key":"10.1016\/j.ucl.2024.03.010_bib29","doi-asserted-by":"crossref","first-page":"529.e23","DOI":"10.1016\/j.urolonc.2018.09.012","article-title":"Diagnosis and management of the growing teratoma syndrome: A single-center experience and review of the literature","volume":"36","author":"Paffenholz","year":"2018","journal-title":"Urol Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1464-410X.2009.09175.x","article-title":"Long-term oncological outcome after post- chemotherapy retroperitoneal lymph node dissection in men with metastatic non- seminomatous germ cell tumor","volume":"106","author":"Fl\u00e9chon","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.ucl.2024.03.010_bib31","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1111\/j.1349-7006.2008.00920.x","article-title":"Hospital procedure volume and prognosis with respect to testicular cancer patients: A population-based study in Osaka, Japan","volume":"99","author":"Suzumura","year":"2008","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ucl.2024.03.010_bib32","article-title":"E\u00a0retroperitoneal lymph node dissection in clinical stage IIA\/B metastatic seminoma: results of the cologne trial of retroperitoneal lymphadenectomy in metastatic seminoma (COTRIMS)","volume":"10","author":"Heidenreich","year":"2023","journal-title":"Ur Urol Oncol"},{"issue":"16","key":"10.1016\/j.ucl.2024.03.010_bib33","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1200\/JCO.22.00624","article-title":"Surgery in early metastatic seminoma: a phase ii trial of retroperitoneal lymph node dissection for testicular seminoma with limited retroperitoneal lymphadenopathy","volume":"41","author":"Daneshmand","year":"2023","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1016\/j.ucl.2024.03.010_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.eururo.2022.10.021","article-title":"Phase 2 single- arm trial of primary retroperitoneal lymph node dissection in patients with seminomatous testicular germ cell tumors with clinical stage IIA\/B (PRIMETEST)","volume":"84","author":"Hiester","year":"2023","journal-title":"Eur Urol"},{"issue":"1","key":"10.1016\/j.ucl.2024.03.010_bib35","first-page":"80","article-title":"Primary retroperitoneal lymph node dissection for seminoma metastatic to the retroperitoneum","volume":"211","author":"Matulewicz","year":"2024","journal-title":"J\u00a0Urol"},{"issue":"18","key":"10.1016\/j.ucl.2024.03.010_bib36","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1200\/JCO.2007.12.0899","volume":"26","author":"Albers","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ucl.2024.03.010_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/0974-7796.204180","article-title":"Reimbursements and frequency of tests in privately insured testicular cancer patients in the United States: Implications to national guidelines","volume":"9","author":"Kamel","year":"2017","journal-title":"Urol Ann"}],"container-title":["Urologic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0094014324000351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0094014324000351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:52:14Z","timestamp":1719283934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0094014324000351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0094014324000351"],"URL":"https:\/\/doi.org\/10.1016\/j.ucl.2024.03.010","relation":{},"ISSN":["0094-0143"],"issn-type":[{"value":"0094-0143","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regionalization of Testis Cancer Care\u2014Is It Necessary?","name":"articletitle","label":"Article Title"},{"value":"Urologic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ucl.2024.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}