{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:06:00Z","timestamp":1793912760835,"version":"4.8.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ultrasonics Sonochemistry"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.ultsonch.2019.104635","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T11:38:18Z","timestamp":1560166698000},"page":"104635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative process"],"prefix":"10.1016","volume":"58","author":[{"given":"Efraim A.","family":"Serna-Galvis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Isaza-Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Moncayo-Lasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Torres-Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ultsonch.2019.104635_b0005","unstructured":"Pan American Health organization, World Hypertension Day, Noncommunicable Dis. Ment. Heal. (2016). http:\/\/www.paho.org\/hq\/index.php?option=com_content&view=article&id=12023%3A17-may-2016-world-hypertension-day&catid=7261%3Aevents-1&Itemid=41080&lang=en (accessed 19.10.2018)."},{"key":"10.1016\/j.ultsonch.2019.104635_b0010","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1016\/j.watres.2013.08.034","article-title":"Occurrence and fate of the angiotensin II receptor antagonist transformation product valsartan acid in the water cycle \u2013 a comparative study with selected \u03b2-blockers and the persistent anthropogenic wastewater indicators carbamazepine and acesulfame","volume":"47","author":"N\u00f6dler","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.ultsonch.2019.104635_b0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s002280050259","article-title":"Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man","volume":"52","author":"Lloyd","year":"1997","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ultsonch.2019.104635_b0020","doi-asserted-by":"crossref","first-page":"9461","DOI":"10.1007\/s11356-013-1868-6","article-title":"Biodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems","volume":"21","author":"Berkner","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ultsonch.2019.104635_b0025","series-title":"Sonochemistry From Basic Princ. to Innov. Appl.","first-page":"1","article-title":"Theory of sonochemistry","author":"Bhangu","year":"2017"},{"key":"10.1016\/j.ultsonch.2019.104635_b0030","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1021\/es061440e","article-title":"Bisphenol A mineralization by integrated ultrasound-UV-iron (II) treatment","volume":"41","author":"Torres","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ultsonch.2019.104635_b0035","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jhazmat.2007.04.056","article-title":"A comparative study of ultrasonic cavitation and Fenton\u2019s reagent for bisphenol A degradation in deionised and natural waters","volume":"146","author":"Torres","year":"2007","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ultsonch.2019.104635_b0040","first-page":"4426","article-title":"Advanced oxidation of antihypertensives losartan and valsartan by photo-electro-Fenton at near-neutral pH using natural organic acids and a dimensional stable anode-gas diffusion electrode (DSA-GDE) system under light emission diode (LED) lighting","author":"Mart\u00ednez-pach\u00f3n","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ultsonch.2019.104635_b0045","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jhazmat.2016.04.009","article-title":"Electrochemical degradation of the antihypertensive losartan in aqueous medium by electro-oxidation with boron-doped diamond electrode","volume":"319","author":"Salazar","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ultsonch.2019.104635_b0050","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.scitotenv.2015.04.053","article-title":"Sonochemical degradation of the pharmaceutical fluoxetine: effect of parameters, organic and inorganic additives and combination with a biological system","volume":"524\u2013525","author":"Serna-Galvis","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ultsonch.2019.104635_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/S1350-4177(96)00021-1","article-title":"Standardization of ultrasonic power for sonochemical reaction","volume":"3","author":"Kimura","year":"1996","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0060","unstructured":"Cheminformatics, Log P calculation, Molinspiration (2018). http:\/\/www.molinspiration.com\/ (accessed 01.03.2018)."},{"key":"10.1016\/j.ultsonch.2019.104635_b0065","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1039\/b007005j","article-title":"Relationship between theoretical oxygen demand and photocatalytic chemical oxygen demand for specific classes of organic chemicals","volume":"125","author":"Kim","year":"2000","journal-title":"Anal. Commun."},{"key":"10.1016\/j.ultsonch.2019.104635_b0070","article-title":"Biocatalysis\/biodegradation database","author":"EAWAG","year":"2018","journal-title":"Pathw. Predict. Syst."},{"key":"10.1016\/j.ultsonch.2019.104635_b0075","unstructured":"EAB-ESP, Acueducto de Bogot\u00e1 (2018). https:\/\/www.acueducto.com.co\/wps\/portal\/EAB (accessed 13.06.2018)."},{"key":"10.1016\/j.ultsonch.2019.104635_b0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ultsonch.2009.04.003","article-title":"Ultrasonic degradation, mineralization and detoxification of diclofenac in water: optimization of operating parameters","volume":"17","author":"Naddeo","year":"2010","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0085","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/10643389.2010.507698","article-title":"Advanced oxidation processes for wastewater treatment: formation of hydroxyl radical and application","volume":"42","author":"Wang","year":"2012","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.ultsonch.2019.104635_b0090","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1021\/ie010096l","article-title":"Sonochemistry: environmental science and engineering applications","volume":"40","author":"Adewuyi","year":"2001","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.ultsonch.2019.104635_b0095","series-title":"Adv. Oxid. Process. Wastewater Treat. \u2013 Emerg. Green Chem. Technol., A, London","first-page":"177","article-title":"Sonolysis","author":"Torres-Palma","year":"2018"},{"key":"10.1016\/j.ultsonch.2019.104635_b0100","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ultsonch.2013.06.012","article-title":"Sonochemical degradation of ciprofloxacin and ibuprofen in the presence of matrix organic compounds","volume":"21","author":"Xiao","year":"2014","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0105","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/hlca.200890051","article-title":"Physicochemical profiling of sartans: a detailed study of ionization constants and distribution coefficients","volume":"91","author":"Tosco","year":"2008","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.ultsonch.2019.104635_b0110","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.rser.2015.10.139","article-title":"Review on the recent improvements in sonochemical and combined sonochemical oxidation processes \u2013 a powerful tool for destruction of environmental contaminants","volume":"55","author":"Sathishkumar","year":"2016","journal-title":"Renew. Sustain. Energy Rev."},{"key":"10.1016\/j.ultsonch.2019.104635_b0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ultsonch.2014.07.006","article-title":"Enhancement and inhibition effects of water matrices during the sonochemical degradation of the antibiotic dicloxacillin","volume":"22","author":"Villegas-Guzman","year":"2015","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jphotochem.2008.05.016","article-title":"Sequential helio-photo-Fenton and sonication processes for the treatment of bisphenol A","volume":"199","author":"Torres","year":"2008","journal-title":"J. Photochem. Photobiol. A"},{"key":"10.1016\/j.ultsonch.2019.104635_b0125","series-title":"Foye\u2019s Princ. Med. Chem.","article-title":"Drug desing and relationship of functional groups to pharmacologic activity","author":"Lemke","year":"2013"},{"key":"10.1016\/j.ultsonch.2019.104635_b0130","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.1016\/j.jece.2018.11.015","article-title":"Photo-electro-Fenton process applied to the degradation of valsartan: effect of parameters, identification of degradation routes and mineralization in combination with a biological system","volume":"6","author":"Mart\u00ednez-Pach\u00f3n","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.ultsonch.2019.104635_b0135","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1021\/jp9902957","article-title":"Mechanism of hydroxyl radical addition to imidazole and subsequent water elimination","volume":"103","author":"Llano","year":"1999","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0140","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1002\/chem.201001236","article-title":"Hydroxyl radical reactions with adenine: reactant complexes, transition states, and product complexes","volume":"16","author":"Cheng","year":"2010","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.ultsonch.2019.104635_b0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-5173(96)04246-9","article-title":"Alcohols and ethanolamines as hydroxyl radical scavengers","volume":"137","author":"Billany","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ultsonch.2019.104635_b0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.watres.2015.12.056","article-title":"Theoretical investigation on the kinetics and mechanisms of hydroxyl radical-induced transformation of parabens and its consequences for toxicity: influence of alkyl-chain length","volume":"91","author":"Gao","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.ultsonch.2019.104635_b0155","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1021\/jp100375c","article-title":"Primary steps in the reaction of OH radicals with peptide systems: perspective from a study of model amides","volume":"114","author":"Doan","year":"2010","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.ultsonch.2019.104635_b0160","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1021\/ja00750a012","article-title":"Sites of attack of hydroxyl radicals on amides in aqueous solution","volume":"93","author":"Hayon","year":"1970","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ultsonch.2019.104635_b0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cej.2012.01.011","article-title":"Photocatalytic degradation of cefazolin over N-doped TiO2 under UV and sunlight irradiation: prediction of the reaction paths via conceptual DFT","volume":"184","author":"Gurkan","year":"2012","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ultsonch.2019.104635_b0170","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.cej.2015.08.154","article-title":"Comparison of route, mechanism and extent of treatment for the degradation of a \u03b2-lactam antibiotic by TiO2 photocatalysis, sonochemistry, electrochemistry and the photo-Fenton system","volume":"284","author":"Serna-Galvis","year":"2016","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ultsonch.2019.104635_b0175","first-page":"1","article-title":"Comparison of toxicities to vibrio fischeri and fish based on discrimination of excess toxicity from baseline level","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ultsonch.2019.104635_b0180","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1039\/C6GC00720A","article-title":"Assessment of predictive models for estimating the acute aquatic toxicity of organic chemicals","volume":"18","author":"Melnikov","year":"2016","journal-title":"Green Chem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ultsonch.2018.09.012","article-title":"Sonochemical degradation of antibiotics from representative classes-considerations on structural effects, initial transformation products, antimicrobial activity and matrix","volume":"50","author":"Serna-Galvis","year":"2018","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0190","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00128-016-1812-9","article-title":"Influence of lipophilicity on the toxicity of bisphenol A and phthalates to aquatic organisms","volume":"97","author":"Mathieu-Denoncourt","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ultsonch.2019.104635_b0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-5793(03)01143-8","article-title":"Differential lipid affinity of xenobiotics and natural compounds","volume":"554","author":"Sandermann","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ultsonch.2019.104635_b0200","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1021\/ed500645v","article-title":"Approaches to determining the oxidation state of nitrogen and carbon atoms in organic compounds for high school students","volume":"92","author":"Jurowski","year":"2015","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.ultsonch.2019.104635_b0205","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/ed400401c","article-title":"Assigning oxidation states to organic compounds via predictions from X-ray photoelectron spectroscopy: a discussion of approaches and recommended improvements","volume":"91","author":"Gupta","year":"2014","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.ultsonch.2019.104635_b0210","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1021\/ed079p700","article-title":"A new approach to understanding oxidation-reduction of compounds in organic chemistry","volume":"79","author":"Menzek","year":"2002","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.ultsonch.2019.104635_b0215","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1016\/j.scitotenv.2010.08.061","article-title":"Combination of advanced oxidation processes and biological treatments for wastewater decontamination \u2013 a review","volume":"409","author":"Oller","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ultsonch.2019.104635_b0220","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.ultsonch.2014.04.002","article-title":"Ultrasonic degradation of acetaminophen in water: effect of sonochemical parameters and water matrix","volume":"21","author":"Villaroel","year":"2014","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2019.104635_b0225","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10311-016-0568-0","article-title":"Degradation of pharmaceuticals by ultrasound-based advanced oxidation process","volume":"14","author":"Rayaroth","year":"2016","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.ultsonch.2019.104635_b0230","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.watres.2019.01.045","article-title":"Degradation of seventeen contaminants of emerging concern in municipal wastewater effluents by sonochemical advanced oxidation processes","volume":"154","author":"Serna-Galvis","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.ultsonch.2019.104635_b0235","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.scitotenv.2019.03.153","article-title":"Effective elimination of fifteen relevant pharmaceuticals in hospital wastewater from Colombia by combination of a biological system with a sonochemical process","volume":"670","author":"Serna-Galvis","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ultsonch.2019.104635_b0240","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ultsonch.2016.01.007","article-title":"High frequency ultrasound as a selective advanced oxidation process to remove penicillinic antibiotics and eliminate its antimicrobial activity from water","volume":"31","author":"Serna-Galvis","year":"2016","journal-title":"Ultrason. Sonochem."}],"container-title":["Ultrasonics Sonochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417719303979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417719303979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:38:12Z","timestamp":1761165492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350417719303979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":48,"alternative-id":["S1350417719303979"],"URL":"https:\/\/doi.org\/10.1016\/j.ultsonch.2019.104635","relation":{},"ISSN":["1350-4177"],"issn-type":[{"value":"1350-4177","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative process","name":"articletitle","label":"Article Title"},{"value":"Ultrasonics Sonochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ultsonch.2019.104635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104635"}}