{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:23:46Z","timestamp":1793996626689,"version":"4.8.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ultrasonics Sonochemistry"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ultsonch.2024.107091","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T20:09:11Z","timestamp":1727813351000},"page":"107091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Ultrasound-assisted solvent extraction of phenolics, flavonoids, and major triterpenoids from Centella asiatica leaves: A comparative study"],"prefix":"10.1016","volume":"111","author":[{"given":"Tara","family":"Khursheed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anees Ahmed","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahood","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rizwan","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfiq","family":"Alsulami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mugabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulzar Ahmad","family":"Nayik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ultsonch.2024.107091_b0005","first-page":"325","article-title":"Account of some important edible medicinal plants and their socio-economic importance. Edible Plants in Health and Diseases: volume 1: cultural","author":"Wali","year":"2022","journal-title":"Practical Economic Value"},{"key":"10.1016\/j.ultsonch.2024.107091_b0010","first-page":"27","article-title":"Potential of biogas and organic fertilizers production through anaerobic digestion of slaughterhouse waste in Ouagadougou, Burkina Faso","author":"Mariam","year":"2023","journal-title":"Int. J. Agri. Biosci."},{"key":"10.1016\/j.ultsonch.2024.107091_b0015","first-page":"272","article-title":"Utilization of waste mixed Pangasius fish fillet and pineapple core to produce peptone for lactic acid bacteria growth media","author":"Rossi","year":"2022","journal-title":"Int. J. Vet. Sci."},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0020","article-title":"Antibacterial activity of aqueous and methanolic extract of mentha piperita against pervasive bacteria isolated from urial the ovis vignei","volume":"43","author":"Ghazwani","year":"2023","journal-title":"Pak. Vet. J."},{"key":"10.1016\/j.ultsonch.2024.107091_b0025","first-page":"18","article-title":"The antioxidant potential of Centella asiatica: a review","volume":"7","author":"Jhansi","year":"2019","journal-title":"J. Med. Plants Stud"},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/ijms18010096","article-title":"Natural antioxidants in foods and medicinal plants: extraction, assessment and resources","volume":"18","author":"Xu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ultsonch.2024.107091_b0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/molecules27020349","article-title":"Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents","volume":"27","author":"Najmi","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2024.107091_b0040","article-title":"Morphological description and ethnobotanical review of the orphan crop Myin-Hkwa (Centella asiatica L.) from Myanmar","volume":"5","author":"Shukurova","year":"2021","journal-title":"Front. Sustain. Food Sys."},{"issue":"12","key":"10.1016\/j.ultsonch.2024.107091_b0045","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3109\/13880209.2012.685946","article-title":"Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials","volume":"50","author":"Puttarak","year":"2012","journal-title":"Pharmaceut. Biol."},{"issue":"11","key":"10.1016\/j.ultsonch.2024.107091_b0050","first-page":"7562","article-title":"Ethano-pharmacology activity & Antioxidant activity of Centella asiatica Plant Parts","volume":"20","author":"Mishra","year":"2022","journal-title":"Neuroquantol."},{"key":"10.1016\/j.ultsonch.2024.107091_b0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.sajb.2021.11.024","article-title":"Studying the effect of morphotype and harvest season on yield and quality of Indian genotypes of Centella asiatica: a potential medicinal herb cum underutilized green leafy vegetable","volume":"145","author":"Rohini","year":"2022","journal-title":"South African J. Bot."},{"key":"10.1016\/j.ultsonch.2024.107091_b0060","unstructured":"R. S. Sabaragamuwa,Phytochemical Profiling and Investigation of Bioactivities of a New Zealand Grown Chemotype of Centella asiatica (GOTUKOLA): A Potential Neuroprotective Herb(Doctoral dissertation, ResearchSpace@ Auckland). (2020)."},{"key":"10.1016\/j.ultsonch.2024.107091_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.568032","article-title":"Therapeutic potential of Centella asiatica and its triterpenes: a review","volume":"11","author":"Sun","year":"2020","journal-title":"Frontiers Pharmacol."},{"issue":"4","key":"10.1016\/j.ultsonch.2024.107091_b0070","doi-asserted-by":"crossref","first-page":"e13903","DOI":"10.1111\/jfpp.13903","article-title":"Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant-based foods","volume":"43","author":"Ng","year":"2019","journal-title":"J. Food Process. Preser."},{"issue":"12","key":"10.1016\/j.ultsonch.2024.107091_b0075","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1002\/ptr.7248","article-title":"Ethnobotany, phytochemistry, pharmacology, and toxicity of Centella asiatica (L.) Urban: a comprehensive review","volume":"35","author":"Biswas","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ultsonch.2024.107091_b0080","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jep.2019.03.017","article-title":"Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract","volume":"236","author":"Viswanathan","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.ultsonch.2024.107091_b0085","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3390\/antiox10091465","article-title":"Green extraction of bioactive compounds from plant biomass and their application in meat as natural antioxidant","volume":"10","author":"Awad","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ultsonch.2024.107091_b0090","series-title":"Bioactive Components: A Sustainable System for Good Health and Well-Being","first-page":"403","article-title":"Biotechnological Tools for Extraction, Identification, and Detection of Bioactive Compounds","author":"Varshney","year":"2022"},{"issue":"4","key":"10.1016\/j.ultsonch.2024.107091_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/ejlt.202000302","article-title":"A review on extraction techniques and its future applications in industry","volume":"123","author":"Geow","year":"2021","journal-title":"Euro. J. Lip. Sci. Technol."},{"key":"10.1016\/j.ultsonch.2024.107091_b0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cofs.2021.02.009","article-title":"Conventional versus green extraction techniques\u2014a comparative perspective","volume":"40","author":"Picot-Allain","year":"2021","journal-title":"Curr. Opinion Food Sci."},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0105","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/13880209.2017.1291694","article-title":"Phytochemical screening and evaluation of in vitro antioxidant and antimicrobial activities of the indigenous medicinal plant Albizia odoratissima","volume":"55","author":"Banothu","year":"2017","journal-title":"Pharma. Biol."},{"key":"10.1016\/j.ultsonch.2024.107091_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2023.106534","article-title":"Comparing the antioxidant properties and volatile compounds of carrot-orange juice blend processed through varied chemical, pasteurization and ultrasound conditions","volume":"98","author":"Khalil","year":"2023","journal-title":"Ultrasonics Sonochem."},{"issue":"2","key":"10.1016\/j.ultsonch.2024.107091_b0115","first-page":"522","article-title":"Comparison of antioxidative potential and punicalagin content of pomegranate peels","volume":"27","author":"Khalil","year":"2017","journal-title":"J. Animal Plant Sci."},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0120","first-page":"197","article-title":"In vitro antioxidant activity and punicalagin content quantification of pomegranate peel obtained as agro-waste after juice extraction","volume":"55","author":"Khalil","year":"2018","journal-title":"Pak. J. Agri. Sci."},{"issue":"7","key":"10.1016\/j.ultsonch.2024.107091_b0125","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/separations8070094","article-title":"Effect of ultrasound-assisted extraction parameters on total polyphenols and its antioxidant activity from mango residues (Mangifera indica L. var","volume":"8","author":"Borr\u00e1s-Enr\u00edquez","year":"2021","journal-title":"Manililla). Separations"},{"issue":"10","key":"10.1016\/j.ultsonch.2024.107091_b0130","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1080\/14786419.2017.1416384","article-title":"Chemical composition and antioxidant activities of essential oil of Hedychium greenii and Hedychium gracile from India","volume":"33","author":"Ray","year":"2019","journal-title":"Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0135","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"issue":"3","key":"10.1016\/j.ultsonch.2024.107091_b0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/0974-8490.65509","article-title":"Determination of polyphenols and free radical scavenging activity of Tephrosia purpurea linn leaves (Leguminosae)","volume":"2","author":"Patel","year":"2010","journal-title":"Pharmacog. Res."},{"issue":"10","key":"10.1016\/j.ultsonch.2024.107091_b0145","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0006-2952(01)00565-2","article-title":"Interaction of enkephalins with oxyradicals","volume":"61","author":"Fontana","year":"2001","journal-title":"Biochem. Pharmacol."},{"issue":"23","key":"10.1016\/j.ultsonch.2024.107091_b0150","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jchromb.2009.03.018","article-title":"An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE)","volume":"877","author":"Rafamantanana","year":"2009","journal-title":"J. Chromatogr. B"},{"issue":"6","key":"10.1016\/j.ultsonch.2024.107091_b0155","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/pca.2578","article-title":"Seasonal variation of triterpenes and phenolic compounds in Australian Centella asiatica (L.) Urb","volume":"26","author":"Alqahtani","year":"2015","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.ultsonch.2024.107091_b0160","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.biopha.2018.05.156","article-title":"Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: in vitro and in vivo study","volume":"105","author":"Arora","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ultsonch.2024.107091_b0165","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fitote.2016.07.011","article-title":"Chemical structures, production and enzymatic transformations of sapogenins and saponins from Centella asiatica (L.)","volume":"114","author":"Azerad","year":"2016","journal-title":"Urban. Fitoterapia"},{"key":"10.1016\/j.ultsonch.2024.107091_b0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11101-017-9528-y","article-title":"Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement","volume":"17","author":"Gray","year":"2018","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.ultsonch.2024.107091_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2020.112888","article-title":"Exploring the potential of microwaves and ultrasounds in the green extraction of bioactive compounds from Humulus lupulus for the food and pharmaceutical industry","volume":"156","author":"Carbone","year":"2020","journal-title":"Ind. Crops Prod."},{"issue":"20","key":"10.1016\/j.ultsonch.2024.107091_b0180","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.3390\/plants12203547","article-title":"Phytochemical analysis and antioxidant activity of centella asiatica extracts: an experimental and theoretical investigation of flavonoids","volume":"12","author":"Kandasamy","year":"2023","journal-title":"Plants"},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40816-023-00353-8","article-title":"Antioxidant, cytotoxic, antibacterial and thrombolytic activities of Centella asiatica L.: possible role of phenolics and flavonoids","volume":"9","author":"Rashid","year":"2023","journal-title":"Clin. Phytosci."},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0190","doi-asserted-by":"crossref","first-page":"C28","DOI":"10.1111\/j.1750-3841.2009.01401.x","article-title":"Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants","volume":"75","author":"Mustafa","year":"2010","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ultsonch.2024.107091_b0195","doi-asserted-by":"crossref","unstructured":"E. Seong, H. Heo, S. Oh, D. Kim, K. I. Jang, J. Lee, Optimization of ultrasound-assisted extraction for triterpene compounds from Centella asiatica using response surface methodology. (2021).","DOI":"10.3746\/jkfn.2021.50.3.294"},{"key":"10.1016\/j.ultsonch.2024.107091_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105506","article-title":"Application of ultrasound in combination with other technologies in food processing: a review","volume":"73","author":"Singla","year":"2021","journal-title":"Ultrasonics Sonochem."},{"key":"10.1016\/j.ultsonch.2024.107091_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111268","article-title":"A review of ultrasound-assisted extraction for plant bioactive compounds: phenolics, flavonoids, thymols, saponins and proteins","volume":"157","author":"Yusoff","year":"2022","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ultsonch.2024.107091_b0210","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jff.2018.01.019","article-title":"Effect of sucrose on the functional composition and antioxidant capacity of buckwheat (Fagopyrum esculentum) sprouts","volume":"43","author":"Jeong","year":"2018","journal-title":"J. Function. Foods"},{"key":"10.1016\/j.ultsonch.2024.107091_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134069","article-title":"Sucrose-induced abiotic stress improves the phytochemical profiles and bioactivities of mung bean sprouts","volume":"400","author":"Yu","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2024.107091_b0220","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fphar.2016.00400","article-title":"In vitro and in vivo antioxidant, anti-hyperlipidemic properties and chemical characterization of Centella asiatica (L.) extract","volume":"7","author":"Kumari","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.ultsonch.2024.107091_b0225","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s12298-020-00844-9","article-title":"Complementation of ROS scavenging secondary metabolites with enzymatic antioxidant defense system augments redox-regulation property under salinity stress in rice","volume":"26","author":"Banik","year":"2020","journal-title":"Physiol. Mol. Biol. Plants"},{"key":"10.1016\/j.ultsonch.2024.107091_b0230","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.indcrop.2015.07.003","article-title":"Influence of different extraction methods on the quantification of selected flavonoids and phenolic acids from Tilia cordata inflorescence","volume":"76","author":"Oniszczuk","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.ultsonch.2024.107091_b0235","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.algal.2017.01.002","article-title":"A comparative assessment of microwave assisted (MAE) and conventional solid-liquid (SLE) techniques for the extraction of phloroglucinol from brown seaweed","volume":"23","author":"Magnusson","year":"2017","journal-title":"Algal Res."},{"issue":"1","key":"10.1016\/j.ultsonch.2024.107091_b0240","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.seppur.2006.08.014","article-title":"Microwave-assisted extraction of antioxidative anthraquinones from roots of Morinda citrifolia","volume":"54","author":"Hemwimon","year":"2007","journal-title":"Separation Purification Technol."},{"issue":"3","key":"10.1016\/j.ultsonch.2024.107091_b0245","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jfda.2016.07.010","article-title":"Extraction and quantification of polyphenols from kinnow (Citrus reticulate) peel using ultrasound and maceration techniques","volume":"25","author":"Safdar","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.ultsonch.2024.107091_b0250","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.foodchem.2019.03.025","article-title":"Effect of solvent and extraction technique on composition and biological activity of Lepidium sativum extracts","volume":"289","author":"Rafi\u0144ska","year":"2019","journal-title":"Food Chem."}],"container-title":["Ultrasonics Sonochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417724003390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417724003390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T17:04:47Z","timestamp":1737306287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350417724003390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":50,"alternative-id":["S1350417724003390"],"URL":"https:\/\/doi.org\/10.1016\/j.ultsonch.2024.107091","relation":{},"ISSN":["1350-4177"],"issn-type":[{"value":"1350-4177","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound-assisted solvent extraction of phenolics, flavonoids, and major triterpenoids from Centella asiatica leaves: A comparative study","name":"articletitle","label":"Article Title"},{"value":"Ultrasonics Sonochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ultsonch.2024.107091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107091"}}