{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:42:15Z","timestamp":1793392935493,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ultrasonics Sonochemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ultsonch.2026.107789","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:12:28Z","timestamp":1771488748000},"page":"107789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Ultrasound-assisted temperature-responsive deep eutectic solvents for simultaneous extraction and separation of the alkaloid components from the white pepper"],"prefix":"10.1016","volume":"127","author":[{"given":"Huixin","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-2829","authenticated-orcid":false,"given":"Yongjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ultsonch.2026.107789_b0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4314\/bcse.v32i1.16","article-title":"Chemical constituents and antioxidant activities of the fruits extracts of Piper Capense","volume":"32","author":"Debebe","year":"2018","journal-title":"Bull. Chem. Soc. Ethiop."},{"key":"10.1016\/j.ultsonch.2026.107789_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113723","article-title":"Chemical composition and anti-inflammatory activity of n-butanol extract of Piper sarmentosum Roxb. In the intestinal porcine epithelial cells (IPEC-J2)","volume":"269","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ultsonch.2026.107789_b0015","article-title":"Alkaloid-rich crude extracts, fractions and piperamide alkaloids of Piper guineense possess promising antibacterial effects","volume":"7","author":"Mgbeahuruike","year":"2018","journal-title":"Antibiotics-Basel"},{"key":"10.1016\/j.ultsonch.2026.107789_b0020","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s11947-017-1994-0","article-title":"Sequential microwave-ultrasound-assisted extraction for isolation of piperine from black pepper (Piper nigrum L.)","volume":"10","author":"Gorgani","year":"2017","journal-title":"Food Bioproc. Tech."},{"key":"10.1016\/j.ultsonch.2026.107789_b0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tifs.2020.11.024","article-title":"Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine","volume":"117","author":"Wang","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ultsonch.2026.107789_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133558","article-title":"Binding mechanism and antioxidant activity of piperine to hemoglobin","volume":"394","author":"Hu","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0035","doi-asserted-by":"crossref","first-page":"15562","DOI":"10.1021\/acs.jafc.1c05670","article-title":"Dietary piperine suppresses obesity-associated breast cancer growth and metastasis by regulating the miR-181c-3p\/PPAR alpha axis","volume":"69","author":"Rajarajan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-60208-1","article-title":"Novel PLGA-encapsulated-nanopiperine promotes synergistic interaction of p53\/PARP-1\/Hsp90 axis to combat ALX-induced-hyperglycemia","volume":"14","author":"Dey","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ultsonch.2026.107789_b0045","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.indcrop.2014.03.040","article-title":"Extraction of piperine from Piper longum using ultrasound","volume":"58","author":"Rathod","year":"2014","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.ultsonch.2026.107789_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28031264","article-title":"Edible plant extracts against aedes aegypti and validation of a Piper nigrum L. ethanolic extract as a natural insecticide","volume":"28","author":"Morais","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107789_b0055","doi-asserted-by":"crossref","DOI":"10.1002\/cssc.202501117","article-title":"Enabling high-boiling-point green solvent recycling using organic solvent nanofiltration membranes","author":"Thomas","year":"2025","journal-title":"ChemSusChem"},{"key":"10.1016\/j.ultsonch.2026.107789_b0060","doi-asserted-by":"crossref","first-page":"S963","DOI":"10.1192\/j.eurpsy.2023.2047","article-title":"Assessment of the quality of life of workers exposed to organic solvents: study of 33 cases","volume":"66","author":"Ziedi","year":"2023","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.ultsonch.2026.107789_b0065","article-title":"An overview on common organic solvents and their toxicity","volume":"28","author":"Joshi","year":"2019","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.ultsonch.2026.107789_b0070","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1007\/s11947-023-03075-4","article-title":"Plant pigments: classification, extraction, and challenge of their application in the food industry","volume":"16","author":"L\u00f3pez-Cruz","year":"2023","journal-title":"Food Bioproc. Tech."},{"key":"10.1016\/j.ultsonch.2026.107789_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.121676","article-title":"Green and sustainable solvents of the future: deep eutectic solvents","volume":"379","author":"Prabhune","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ultsonch.2026.107789_b0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cofs.2019.03.002","article-title":"Bioavailability and biological effects of bioactive compounds extracted with natural deep eutectic solvents and ionic liquids: advantages over conventional organic solvents","volume":"26","author":"Murador","year":"2019","journal-title":"Curr. Opin. Food Sci."},{"key":"10.1016\/j.ultsonch.2026.107789_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.coche.2024.101088","article-title":"Trends and perspectives on the ultrasound-assisted extraction of bioactive compounds using natural deep eutectic solvents","volume":"47","author":"Pereira","year":"2025","journal-title":"Curr. Opin. Chem. Eng."},{"key":"10.1016\/j.ultsonch.2026.107789_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174758","article-title":"Evaluation of biodegradability, toxicity and ecotoxicity of organic acid-based deep eutectic solvents","volume":"948","author":"Hayyan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ultsonch.2026.107789_b0095","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ecoenv.2014.09.034","article-title":"Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents","volume":"112","author":"Radosevic","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ultsonch.2026.107789_b0100","article-title":"Optimization of natural deep eutectic solvents extraction of flavonoids from Xanthoceras sorbifolia Bunge by response surface methodology","volume":"31","author":"Feng","year":"2023","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.ultsonch.2026.107789_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2023.136645","article-title":"A deep eutectic solvent binary-phase system for alkaloid extraction from chinese herb Evodia lepta residue and its mechanism","volume":"398","author":"Yu","year":"2023","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.ultsonch.2026.107789_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141904","article-title":"Supramolecular deep eutectic solvents as green media for efficient extraction of tea polyphenols and its application in bio-active film","volume":"465","author":"Huang","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0115","article-title":"Ultrasound assisted deep eutectic solvent-based extraction of Montepulciano d\u2019 Abruzzo grape seeds for the recovery of the grape seed oil and its biological evaluation","author":"Marinaccio","year":"2025","journal-title":"Food Chem.: X"},{"key":"10.1016\/j.ultsonch.2026.107789_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.focha.2024.100656","article-title":"Ultrasound assisted lycopene extraction from tomato skin waste by volatile natural deep eutectic solvent","author":"Marinaccio","year":"2024","journal-title":"Food Chem. Adv."},{"key":"10.1016\/j.ultsonch.2026.107789_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.121899","article-title":"Database of deep eutectic solvents and their physical properties: a review","volume":"384","author":"Omar","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ultsonch.2026.107789_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1279552","article-title":"Natural deep eutectic solvents-based green extraction of vanillin: optimization, purification, and bioactivity assessment","volume":"10","author":"Xu","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ultsonch.2026.107789_b0135","article-title":"Responsive switchable deep eutectic solvents: a review","volume":"34","author":"Zhang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ultsonch.2026.107789_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.126607","article-title":"Alcohol-based deep eutectic solvents with pH-responsive hydrophobicity for the analysis of herbicides in water and fruit juice samples","volume":"339","author":"Fattahi","year":"2024","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.ultsonch.2026.107789_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2021.114430","article-title":"Experimental and theoretical study on the catalytic degradation of lignin by temperature-responsive deep eutectic solvents","volume":"177","author":"Wang","year":"2022","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.ultsonch.2026.107789_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137255","article-title":"CO2 -responsive deep eutectic solvents for the enhanced extraction of hesperidin from Fertile orange peel","volume":"432","author":"Wang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300098","article-title":"Advances of responsive deep eutectic solvents and application in extraction and separation of bioactive compounds","volume":"46","author":"Zhang","year":"2023","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.ultsonch.2026.107789_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.122063","article-title":"Extraction of Lycium barbarum polysaccharides using temperature-switchable deep eutectic solvents: a sustainable methodology for recycling and reuse of the extractant","volume":"383","author":"Tang","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ultsonch.2026.107789_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.129898","article-title":"Switchable deep eutectic solvents for the extraction of phlorizin and trilobatin from sweet tea (Lithocarpus litseifolius (Hance) Chun)","volume":"356","author":"Yang","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.ultsonch.2026.107789_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143065","article-title":"Ultrasound-assisted ternary temperature-responsive deep eutectic solvents for extraction of carotenoids from tomato samples","volume":"473","author":"Shen","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2020.123047","article-title":"Temperature-responsive deep eutectic solvents as green and recyclable media for the efficient extraction of polysaccharides from Ganoderma lucidum","volume":"274","author":"Cai","year":"2020","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.ultsonch.2026.107789_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2022.114082","article-title":"Sustainable extraction of polyphenols from millet using switchable deep eutectic solvents","volume":"170","author":"Zhang","year":"2022","journal-title":"Lwt-Food Sci. Technol."},{"key":"10.1016\/j.ultsonch.2026.107789_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.156012","article-title":"A novel temperature-responsive biphasic deep eutectic solvent-based solvent system: Integrated efficient extraction, enrichment and recovery of phytochemicals","volume":"499","author":"Cai","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ultsonch.2026.107789_b0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/suschem4010005","article-title":"Innovative green approach for extraction of piperine from black pepper based on response surface methodology","volume":"4","author":"Lwamba","year":"2023","journal-title":"Sustainable Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0195","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1007\/s11947-025-03746-4","article-title":"Chitin extraction at room temperature using a novel temperature-responsive switchable deep eutectic system with enhanced recyclability","volume":"18","author":"Liu","year":"2025","journal-title":"Food Bioproc. Tech."},{"key":"10.1016\/j.ultsonch.2026.107789_b0200","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijbiomac.2017.12.096","article-title":"Physicochemical characterization and in vitro hypoglycemic activities of polysaccharides from Sargassum pallidum by microwave-assisted aqueous two-phase extraction","volume":"109","author":"Cao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ultsonch.2026.107789_b0205","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.talanta.2018.01.013","article-title":"A new tool for the evaluation of the analytical procedure: Green Analytical Procedure Index","volume":"181","author":"Plotka-Wasylka","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.ultsonch.2026.107789_b0210","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3390\/analytica5030030","article-title":"Modified GAPI (MoGAPI) tool and software for the assessment of method greenness: case studies and applications","volume":"5","author":"Mansour","year":"2024","journal-title":"Analytica"},{"key":"10.1016\/j.ultsonch.2026.107789_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24162897","article-title":"Ultrasonic extraction of tropane alkaloids from radix physochlainae using as extractant an ionic liquid with similar structure","author":"Yohannes","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107789_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107644","article-title":"Ultrasound-Assisted green extraction and resin purification of Hypaphorine from Nanhaia speciosa using deep eutectic solvents","author":"Dai","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128110","article-title":"Electrochemical behaviour of piperine. Comparison with control antioxidants","volume":"339","author":"Carp","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107789_b0230","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/03601234.2020.1869477","article-title":"In vitro \u03b1-amylase and \u03b1-glucosidase enzyme inhibition and antioxidant activity by capsaicin and piperine from Capsicum chinense and Piper nigrum fruits","volume":"56","author":"Maga\u00f1a-Barajas","year":"2021","journal-title":"J. Environ. Sci. Health Part B-Pesticides Food Contam. Agric. Wastes"}],"container-title":["Ultrasonics Sonochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726000544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726000544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:38:10Z","timestamp":1777610290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350417726000544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":46,"alternative-id":["S1350417726000544"],"URL":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.107789","relation":{},"ISSN":["1350-4177"],"issn-type":[{"value":"1350-4177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound-assisted temperature-responsive deep eutectic solvents for simultaneous extraction and separation of the alkaloid components from the white pepper","name":"articletitle","label":"Article Title"},{"value":"Ultrasonics Sonochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.107789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107789"}}