{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:13:24Z","timestamp":1787318004130,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006701","name":"Umm Al-Qura University","doi-asserted-by":"publisher","award":["26UQU4280107GSSR01"],"award-info":[{"award-number":["26UQU4280107GSSR01"]}],"id":[{"id":"10.13039\/501100006701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ultrasonics Sonochemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ultsonch.2026.107856","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:55:27Z","timestamp":1776243327000},"page":"107856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Enzymes-assisted green ultrasonic extraction with UPLC-DAD quantification of phenolic compounds in chia seeds with a comparative evaluation based on geographical origins"],"prefix":"10.1016","volume":"129","author":[{"given":"Rizwan","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aljawharah","family":"Alqathama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Aldholmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alkawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Alnaeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz","family":"Algarzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Amir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Riaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ultsonch.2026.107856_b0005","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1055\/a-0586-4711","article-title":"Therapeutic Perspectives on Chia seed and its Oil: a Review","volume":"84","author":"Parker","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.ultsonch.2026.107856_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105480","article-title":"Health-promoting approaches of the use of chia seeds","volume":"103","author":"Motyka","year":"2023","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.ultsonch.2026.107856_b0015","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/87559129.2013.818014","article-title":"Chia seed (Salvia hispanica): an Ancient Grain and a New Functional Food","volume":"29","author":"Mu\u00f1oz","year":"2013","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.ultsonch.2026.107856_b0020","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.foodchem.2017.04.002","article-title":"Characterization of phenolic compounds in chia (Salvia hispanica L.) seeds, fiber flour and oil","volume":"232","author":"Oliveira-Alves","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107856_b0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/molecules25010011","article-title":"Chia Seeds (Salvia Hispanica L.): an Overview\u2014Phytochemical Profile, Isolation Methods, and Application","volume":"25","author":"Knez Hrn\u010di\u010d","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107856_b0030","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jff.2017.06.044","article-title":"Phenolic and polyphenolic profiles of chia seeds and their in vitro biological activities","volume":"35","author":"Rahman","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.ultsonch.2026.107856_b0035","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/14786419.2020.1761357","article-title":"Characterization of free and insoluble-bound phenolics of chia (Salvia hispanica L.) seeds","volume":"36","author":"Mitrovi\u0107","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.ultsonch.2026.107856_b0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibtech.2011.06.014","article-title":"Enzyme-assisted extraction of bioactives from plants","volume":"30","author":"Puri","year":"2012","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ultsonch.2026.107856_b0045","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1007\/s13197-015-1967-0","article-title":"Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review","volume":"53","author":"Ullah","year":"2016","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.ultsonch.2026.107856_b0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/ijfs.12339","article-title":"Physical properties, chemical characterization and fatty acid composition of <scp>M<\/scp> exican chia (<scp>S<\/scp> alvia hispanica <scp>L<\/scp> .) seed","volume":"49","author":"Porras-Loaiza","year":"2014","journal-title":"Int. J. Food Sci. Technol."},{"key":"10.1016\/j.ultsonch.2026.107856_b0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.supflu.2016.02.010","article-title":"Valorization of chia (Salvia hispanica) seed cake by means of supercritical fluid extraction","volume":"112","author":"Guindani","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.ultsonch.2026.107856_b0060","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.foodchem.2018.09.133","article-title":"Effect of the solvent composition on the profile of phenolic compounds extracted from chia seeds","volume":"275","author":"Alc\u00e2ntara","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107856_b0065","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.foodchem.2016.05.047","article-title":"Enzyme-assisted extraction of phenolics from winemaking by-products: Antioxidant potential and inhibition of alpha-glucosidase and lipase activities","volume":"212","author":"de Camargo","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107856_b0070","article-title":"Complex Enzyme-Assisted Extraction Releases Antioxidative Phenolic Compositions from Guava Leaves","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107856_b0075","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1186\/s40064-016-2367-2","article-title":"Effect of proteolytic activities in combination with the pectolytic activities on extractability of the fat and phenolic compounds from olives","author":"Moustakime","year":"2016","journal-title":"Springerplus 5"},{"key":"10.1016\/j.ultsonch.2026.107856_b0080","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.3390\/foods12163013","article-title":"Physico-Chemical and Nutritional Properties of Chia Seeds from Latin American Countries","volume":"12","author":"Vera-Cespedes","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.ultsonch.2026.107856_b0085","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1007\/s11694-022-01447-6","article-title":"Improved production of antioxidant-phenolic compounds and certain fungal phenolic-associated enzymes under solid-state fermentation of chia seeds with Trichoderma reesei: response surface methodology-based optimization","volume":"16","author":"Abdel-Aty","year":"2022","journal-title":"J. Food Meas. Charact."},{"key":"10.1016\/j.ultsonch.2026.107856_b0090","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s10068-021-00902-2","article-title":"Egyptian chia seeds (Salvia hispanica L.) during germination: Upgrading of phenolic profile, antioxidant, antibacterial properties and relevant enzymes activities","volume":"30","author":"Abdel-Aty","year":"2021","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.ultsonch.2026.107856_b0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chroma.2014.04.007","article-title":"Phytochemical profile and nutraceutical potential of chia seeds (Salvia hispanica L.) by ultra high performance liquid chromatography","volume":"1346","author":"Mart\u00ednez-Cruz","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ultsonch.2026.107856_b0100","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.talanta.2010.03.028","article-title":"Advanced QSRR modeling of peptides behavior in RPLC","volume":"81","author":"Bodzioch","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.ultsonch.2026.107856_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105696","article-title":"Green and novel ultrasonic extraction with UHPLC-MSMS analysis of natural sweetener (Glycyrrhizic acid) from Glycyrrhiza glabra; a multifactorial mechanistic evaluation based on statistical analysis","volume":"77","author":"Ahmad","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107856_b0110","unstructured":"Committee for Medicinal Products for Human Use, ICH Harmonised Guideline: Validation of analytical procedures - Q2(R2), ICH Eur. Med. Agency Step 2b (2022) 1\u201339."},{"key":"10.1016\/j.ultsonch.2026.107856_b0115","unstructured":"J. Corona-Jim\u00e9nez, E.; Mart\u00ednez-Navarrete, N.; Ruiz-Espinosa, H.; Carranza-Concha, Ultrasound-assisted extraction of phenolic compounds from chia (Salvia hispanica L.) seeds and their antioxidant activity, Agrociencia 50 (2016) 403\u2013412. https:\/\/www.scielo.org.mx\/scielo.php?pid=S1405-31952016000400403&script=sci_arttext."},{"key":"10.1016\/j.ultsonch.2026.107856_b0120","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3390\/foods10123001","article-title":"Assessment of the Phytochemical and Nutrimental Composition of Dark Chia seed (Salvia hisp\u00e1nica L.)","volume":"10","author":"Rodr\u00edguez Lara","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.ultsonch.2026.107856_b0125","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/aob\/mcae123","article-title":"Chia (Salvia hispanica L.), a functional \u2018superfood\u2019: new insights into its botanical, genetic and nutraceutical characteristics","volume":"134","author":"Zare","year":"2024","journal-title":"Ann. Bot."},{"key":"10.1016\/j.ultsonch.2026.107856_b0130","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3390\/molecules24132452","article-title":"Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic stress","volume":"24","author":"Sharma","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107856_b0135","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3390\/ijms25021234","article-title":"Abscisic Acid Affects Phenolic Acid Content to increase Tolerance to UV-B stress in Rhododendron chrysanthum Pall","volume":"25","author":"Zhou","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ultsonch.2026.107856_b0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/antiox14010074","article-title":"The Role of Polyphenols in Abiotic stress Tolerance and their Antioxidant Properties to Scavenge Reactive Oxygen Species and Free Radicals","volume":"14","author":"Rao","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.ultsonch.2026.107856_b0145","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.15835\/nbha48311957","article-title":"Variation in Nigella sativa quality and its standardization via instrumental analysis: a study based on geographical origin","volume":"48","author":"Ahmad","year":"2020","journal-title":"Not. Bot. Horti Agrobot. Cluj-Napoca"},{"key":"10.1016\/j.ultsonch.2026.107856_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4772","article-title":"Quality variation and standardization of black pepper (<scp> Piper nigrum <\/scp>): a comparative geographical evaluation based on instrumental and metabolomics analysis","volume":"34","author":"Ahmad","year":"2020","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ultsonch.2026.107856_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/241053","article-title":"Chemical and Functional Properties of Chia seed (Salvia hispanica L.) Gum","volume":"2014","author":"Segura-Campos","year":"2014","journal-title":"Int. J. Food Sci."},{"key":"10.1016\/j.ultsonch.2026.107856_b0160","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.lwt.2014.04.014","article-title":"Chemical characterization and antioxidant potential of Chilean chia seeds and oil (Salvia hispanica L.)","volume":"59","author":"Marineli","year":"2014","journal-title":"LWT - Food Sci. Technol."},{"key":"10.1016\/j.ultsonch.2026.107856_b0165","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1002\/jsfa.11256","article-title":"Metabolomic analysis and antioxidant activity of wild type and mutant chia (<scp> Salvia hispanica <\/scp> L.) stem and flower grown under different irrigation regimes","volume":"101","author":"de Falco","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.ultsonch.2026.107856_b0170","first-page":"191","article-title":"Antioxidants, protein, oil content and fatty acids profiles of chia seeds (Salvia hispanica L.) genotype Tzotzol growing in three tropical ecosystems of Bolivia, Ecuador and Paraguay","volume":"3","author":"Ayerza","year":"2019","journal-title":"Int. J. Agric. Environ. Food Sci."},{"key":"10.1016\/j.ultsonch.2026.107856_b0175","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.foodchem.2016.10.115","article-title":"Chemical composition of Brazilian chia seeds grown in different places","volume":"221","author":"da Silva","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107856_b0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.molliq.2014.05.006","article-title":"On the solubility of quercetin","volume":"197","author":"Abraham","year":"2014","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ultsonch.2026.107856_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19072126","article-title":"\u201cSweet Flavonoids\u201d: Glycosidase-Catalyzed modifications","volume":"19","author":"Sl\u00e1mov\u00e1","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ultsonch.2026.107856_b0190","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.3390\/molecules22101648","article-title":"Complex Enzyme-Assisted Extraction Releases Antioxidative Phenolic Compositions from Guava Leaves","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107856_b0195","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/biof.552210125","article-title":"Anti\u2010inflammatory and anti\u2010allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism","volume":"21","author":"Osakabe","year":"2004","journal-title":"Biofactors"},{"key":"10.1016\/j.ultsonch.2026.107856_b0200","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3164\/jcbn.40.92","article-title":"Ferulic Acid: Therapeutic potential through its Antioxidant Property","volume":"40","author":"Srinivasan","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.ultsonch.2026.107856_b0205","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.jnutbio.2013.05.007","article-title":"Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism","volume":"24","author":"Ji","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ultsonch.2026.107856_b0210","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/nu17091579","article-title":"The Effects of Quercetin on Vascular Endothelium, Inflammation, Cardiovascular Disease and Lipid Metabolism\u2014A Review","volume":"17","author":"Ozorowski","year":"2025","journal-title":"Nutrients"}],"container-title":["Ultrasonics Sonochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726001215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726001215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:04:36Z","timestamp":1781136276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350417726001215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S1350417726001215"],"URL":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.107856","relation":{},"ISSN":["1350-4177"],"issn-type":[{"value":"1350-4177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enzymes-assisted green ultrasonic extraction with UPLC-DAD quantification of phenolic compounds in chia seeds with a comparative evaluation based on geographical origins","name":"articletitle","label":"Article Title"},{"value":"Ultrasonics Sonochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.107856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107856"}}