{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:14:07Z","timestamp":1790633647044,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008083","name":"Xihua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ultrasonics Sonochemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ultsonch.2026.107977","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:08:01Z","timestamp":1784934481000},"page":"107977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Upcycling Citrus aurantium leaf by\u2011products into bioactive phenolics: Ionic liquid-ultrasound synergy for green extraction, UPLC-QTOF-MS\/MS profiling, and hypoglycemic activity"],"prefix":"10.1016","volume":"132","author":[{"given":"Yaru","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ultsonch.2026.107977_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10163-025-02251-2","article-title":"From waste to value: traditional to innovative approaches for agricultural and food waste valorization","volume":"27","author":"Munir","year":"2025","journal-title":"J. Mater. Cycles Waste"},{"key":"10.1016\/j.ultsonch.2026.107977_b0010","doi-asserted-by":"crossref","first-page":"8677","DOI":"10.3390\/su16198677","article-title":"Legal barriers in sustainable agriculture: valorization of agri-food waste and pesticide use reduction","volume":"16","author":"Nicastro","year":"2024","journal-title":"Sustainability"},{"key":"10.1016\/j.ultsonch.2026.107977_b0015","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3390\/antiox14060650","article-title":"Bioactive compounds of agro-industrial by-products: Current trends, recovery, and possible utilization","volume":"14","author":"Saini","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.ultsonch.2026.107977_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105194","article-title":"Valorization of agro-food by-products: Advancing sustainability and sustainable development goals 2030 through functional compounds recovery","volume":"62","author":"Ahmad","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.ultsonch.2026.107977_b0025","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1080\/10408398.2021.1969891","article-title":"Nutrients and bioactives in citrus fruits: Different citrus varieties, fruit parts, and growth stages","volume":"63","author":"Lu","year":"2023","journal-title":"Crit. Rev. Food Sci."},{"key":"10.1016\/j.ultsonch.2026.107977_b0030","doi-asserted-by":"crossref","unstructured":"I. Suntar, H. Khan, S. Patel, R. Celano, L. Rastrelli, 2018. An overview on Citrus aurantium L.: Its functions as food ingredient and therapeutic agent. Oxid. Med. Cell. Longev. 2018, 7864269. doi: 10.1155\/2018\/7864269.","DOI":"10.1155\/2018\/7864269"},{"key":"10.1016\/j.ultsonch.2026.107977_b0035","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s11101-020-09725-1","article-title":"Aurantii Fructus: a systematic review of ethnopharmacology, phytochemistry and pharmacology","volume":"20","author":"Gao","year":"2021","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.ultsonch.2026.107977_b0040","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/pr13010120","article-title":"Recent developments in Citrus aurantium L.: An overview of bioactive compounds, extraction techniques, and technological applications","volume":"13","author":"Fern\u00e1ndez-Cabal","year":"2025","journal-title":"Processes"},{"key":"10.1016\/j.ultsonch.2026.107977_b0045","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3390\/molecules30040930","article-title":"Citrus aurantium Flowers: Overview of chemistry, functionality, and technological applications","volume":"30","author":"Seyyedi-Mansour","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107977_b0050","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.3390\/molecules26195832","article-title":"Citrus aurantium L. active constituents, biological effects and extraction methods. an updated review","volume":"26","author":"Maksoud","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107977_b0055","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3390\/agronomy12061466","article-title":"Essential oil of Citrus aurantium L. leaves: composition, antioxidant activity, elastase and collagenase inhibition","volume":"12","author":"Oulebsir","year":"2022","journal-title":"Agronomy"},{"key":"10.1016\/j.ultsonch.2026.107977_b0060","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/11263504.2024.2320127","article-title":"Phytochemical analysis, antiproliferative, antibacterial, antifungal, and antiviral activities of bitter orange (Citrus aurantium) leaf essential oil","volume":"158","author":"Mejri","year":"2024","journal-title":"Plant Biosyst."},{"key":"10.1016\/j.ultsonch.2026.107977_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116978","article-title":"Theoritical evaluation of Citrus aurantium leaf extract as green inhibitor for chemical and biological corrosion of mild steel in acidic solution: Statistical, molecular dynamics, docking, and quantum mechanics study","volume":"343","author":"Khadom","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ultsonch.2026.107977_b0070","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.3390\/molecules28217251","article-title":"Biological activities of Citrus aurantium leaf extract by optimized ultrasound-assisted extraction","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107977_b0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s13596-019-00379-9","article-title":"In-vitro antioxidant and antimicrobial activities of some varieties citrus grown in Algeria","volume":"20","author":"Haraoui","year":"2020","journal-title":"Adv. Tradit. Med."},{"key":"10.1016\/j.ultsonch.2026.107977_b0080","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.3390\/plants12142732","article-title":"Flavonoids: Overview of biosynthesis, biological activity, and current extraction techniques","volume":"12","author":"Liga","year":"2023","journal-title":"Plants"},{"key":"10.1016\/j.ultsonch.2026.107977_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111268","article-title":"A review of ultrasound-assisted extraction for plant bioactive compounds: Phenolics, flavonoids, thymols, saponins and proteins","volume":"157","author":"Yusoff","year":"2022","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ultsonch.2026.107977_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117204","article-title":"Ultrasound-assisted extraction methods for the determination of organic contaminants in solid and liquid samples","volume":"166","author":"P\u00e9rez","year":"2023","journal-title":"TrAC Trend. Anal. Chem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ultsonch.2019.05.014","article-title":"Recent advances in ultrasound application as a novel technique in analysis, processing and quality control of fruits, juices and dairy products industries: A review","volume":"57","author":"Firouz","year":"2019","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107282","article-title":"Phenolics from Chaenomeles speciosa leaves: Ionic liquid-based ultrasound-assisted extraction, adsorptive purification, UPLC\u2013QqQ\u2013MS\/MS quantification, and bioactivity assessment","volume":"114","author":"Hou","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124469","article-title":"Indisputable roles of different ionic liquids, deep eutectic solvents and nanomaterials in green chemistry for sustainable organic synthesis","volume":"399","author":"Alqahtani","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ultsonch.2026.107977_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.joei.2023.101313","article-title":"A comparative review of extractive desulfurization using designer solvents: Ionic liquids & deep eutectic solvents","volume":"110","author":"Jha","year":"2023","journal-title":"J. Energy Inst."},{"key":"10.1016\/j.ultsonch.2026.107977_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2024.106877","article-title":"Application of ionic liquid ultrasound-assisted extraction (IL-UAE) of lycopene from guava (Psidium guajava L.) by response surface methodology and artificial neural network-genetic algorithm","volume":"106","author":"Wang","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2024.106973","article-title":"Optimization of process conditions for ionic liquid-based ultrasound-enzyme-assisted extraction of resveratrol from Polygonum Cuspidatum","volume":"108","author":"Zhao","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpba.2018.05.002","article-title":"A facile and selective approach to the qualitative and quantitative analysis of triterpenoids and phenylpropanoids by UPLC\/Q-TOF-MS\/MS for the quality control of Ilex rotunda","volume":"157","author":"Yang","year":"2018","journal-title":"J. Pharmaceut. Biomed."},{"key":"10.1016\/j.ultsonch.2026.107977_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.70029","article-title":"The rise of Type 2 diabetes in children and adolescents: An emerging pandemic","volume":"41","author":"Goyal","year":"2025","journal-title":"Diabetes-Metab. Res."},{"key":"10.1016\/j.ultsonch.2026.107977_b0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/medsci13030087","article-title":"Pathophysiological mechanisms of diabetes-induced macrovascular and microvascular complications: the role of oxidative stress","volume":"13","author":"Roy","year":"2025","journal-title":"Med. Sci."},{"key":"10.1016\/j.ultsonch.2026.107977_b0140","article-title":"Metformin therapy and cognitive dysfunction in patients with type 2 diabetes: a meta-analysis and systematic review","volume":"99","author":"Zhang","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.ultsonch.2026.107977_b0145","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.3390\/molecules28103996","article-title":"Food polyphenols and type II diabetes mellitus: pharmacology and mechanisms","volume":"28","author":"Naz","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107977_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2024.116405","article-title":"Purification of phenolics from Plantago depressa by macroporous resin: Adsorption\/desorption characteristics, chromatographic process development and UPLC-TQ-MS\/MS quantitative analysis","volume":"203","author":"Cao","year":"2024","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.ultsonch.2026.107977_b0155","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1039\/D2GC04749G","article-title":"Imidazolium based ionic liquid-phase green catalytic reactions","volume":"25","author":"Migowski","year":"2023","journal-title":"Green Chem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0160","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1039\/c2cs15362a","article-title":"Ether-and alcohol-functionalized task-specific ionic liquids: attractive properties and applications","volume":"41","author":"Tang","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ultsonch.2026.107977_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139521","article-title":"Platycodon grandiflorum saponins: Ionic liquid-ultrasound-assisted extraction, antioxidant, whitening, and antiaging activity","volume":"451","author":"Shang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107228","article-title":"Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism","volume":"113","author":"Niu","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2021.130195","article-title":"Ionic liquid and ultrasound-assisted extraction of chestnut shell pigment with good hair dyeing capability","volume":"335","author":"Zhu","year":"2022","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.ultsonch.2026.107977_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.142908","article-title":"Green valorization of Chaenomelis Fructus agro-industrial by-products as a source of phenolics: Ultrasound-assisted extraction, adsorptive enrichment and quality control","volume":"472","author":"Hou","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.107977_b0185","first-page":"42","article-title":"Preparative separation of polyphenols from water-soluble fraction of Chinese propolis using macroporous absorptive resin coupled with preparative high performance liquid chromatography","volume":"1012","author":"Li","year":"2016","journal-title":"Journal of Chromatography B"},{"key":"10.1016\/j.ultsonch.2026.107977_b0190","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/molecules25020357","article-title":"Systematic detection and identification of bioactive ingredients from Citrus aurantium L. var. amara using HPLC-Q-TOF-MS combined with a screening method","volume":"25","author":"Yu","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ultsonch.2026.107977_b0195","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jpba.2019.03.056","volume":"171","author":"Luo","year":"2019","journal-title":"J. Pharmaceut. Biomed."},{"issue":"10","key":"10.1016\/j.ultsonch.2026.107977_b0200","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.3390\/nu12102907","article-title":"Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies","volume":"12","author":"Gandhi","year":"2020","journal-title":"Nutrients"}],"container-title":["Ultrasonics Sonochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726002427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726002427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:22:11Z","timestamp":1787638931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350417726002427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S1350417726002427"],"URL":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.107977","relation":{},"ISSN":["1350-4177"],"issn-type":[{"value":"1350-4177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upcycling Citrus aurantium leaf by\u2011products into bioactive phenolics: Ionic liquid-ultrasound synergy for green extraction, UPLC-QTOF-MS\/MS profiling, and hypoglycemic activity","name":"articletitle","label":"Article Title"},{"value":"Ultrasonics Sonochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.107977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107977"}}