{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:20:00Z","timestamp":1787642400171,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505169"],"award-info":[{"award-number":["82505169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ultrasonics Sonochemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ultsonch.2026.108000","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:24:27Z","timestamp":1786227867000},"page":"108000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Experiment-confirmed machine learning optimization of NADES extraction with ultrasound assistance and Mendelian randomization evidence on antioxidant effects of ferulic acid and ligustilide from Angelicae Sinensis Radix"],"prefix":"10.1016","volume":"132","author":[{"given":"Yangyang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ultsonch.2026.108000_b0005","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3390\/biom14121623","article-title":"Z-Ligustilide: A Potential Therapeutic Agent for Atherosclerosis Complicating Cerebrovascular Disease","volume":"14","author":"Shen","year":"2025","journal-title":"Biomolecules"},{"issue":"18","key":"10.1016\/j.ultsonch.2026.108000_b0010","first-page":"2759","article-title":"Pharmacokinetic study of puerarin and ferulic acid alone and in combination in focal cerebral ischemia model rats","volume":"46","author":"Yang","year":"2015","journal-title":"Chinese Medicinal Herb"},{"key":"10.1016\/j.ultsonch.2026.108000_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"issue":"06","key":"10.1016\/j.ultsonch.2026.108000_b0020","first-page":"172","article-title":"Research status of chemical constituents and pharmacological effects of Angelica sinensis","volume":"13","author":"Zhao, j. and X. Xia","year":"2020","journal-title":"Journal of Clinical Rational Drug Use"},{"issue":"4","key":"10.1016\/j.ultsonch.2026.108000_b0025","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.3390\/molecules28041942","article-title":"Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities","volume":"28","author":"Tang","year":"2023","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.ultsonch.2026.108000_b0030","first-page":"200","article-title":"Ligustilide Inhibits the PI3K\/AKT Signalling Pathway and Suppresses Cholangiocarcinoma Cell Proliferation, Migration, and Invasion","volume":"20","author":"Yue","year":"2024","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.ultsonch.2026.108000_b0035","volume":"Volume I","author":"Commission","year":"2020"},{"issue":"6","key":"10.1016\/j.ultsonch.2026.108000_b0040","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/1747493018778713","article-title":"Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke","volume":"13","author":"David","year":"2018","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.ultsonch.2026.108000_b0045","article-title":"Ultrasound-assisted extraction of functional compound from mulberry (Morus alba L.) leaf using response surface methodology and effect of microencapsulation by spray drying on quality of optimized extract","volume":"82","author":"Supasit","year":"2022","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139241","article-title":"Optimization of adsorption performance of cerium-loaded intercalated bentonite by CCD-RSM and GA-BPNN and its application in simultaneous removal of phosphorus and ammonia nitrogen","volume":"336","author":"Lu","year":"2023","journal-title":"Chemosphere"},{"issue":"41","key":"10.1016\/j.ultsonch.2026.108000_b0055","doi-asserted-by":"crossref","first-page":"24454","DOI":"10.1039\/D0RA04111D","article-title":"Pharmacokinetic-pharmacodynamic modeling for Moutan Cortex\/Moutan Cortex charcoal and the contributions of the chemical component using support vector regression with particle swarm optimization","volume":"10","author":"Pan","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ultsonch.2026.108000_b0060","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.2147\/IJGM.S495663","article-title":"Machine Learning Research Trends in Traditional Chinese Medicine: A Bibliometric Review","volume":"17","author":"Lim","year":"2024","journal-title":"Int J Gen Med"},{"issue":"9","key":"10.1016\/j.ultsonch.2026.108000_b0065","doi-asserted-by":"crossref","first-page":"7992","DOI":"10.1039\/D5RA09650B","article-title":"Machine learning-driven optimization of extraction process and development of quality standards for traditional Chinese medicine (TCM) formulae in primary liver cancer","volume":"16","author":"Gao","year":"2026","journal-title":"RSC Adv."},{"key":"10.1016\/j.ultsonch.2026.108000_b0070","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.2147\/RMHP.S318806","article-title":"Comparison of Back-Propagation Neural Network, LACE Index and HOSPITAL Score in Predicting All-Cause Risk of 30-Day Readmission","volume":"14","author":"Lin","year":"2021","journal-title":"Risk Manag Healthc Policy"},{"key":"10.1016\/j.ultsonch.2026.108000_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103286","article-title":"Identification and validation of an explainable early-stage chronic kidney disease prediction model: a multicenter retrospective study","volume":"84","author":"He","year":"2025","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ultsonch.2026.108000_b0080","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Neil","year":"2018","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.ultsonch.2026.108000_b0085","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1161\/STROKEAHA.120.032617","article-title":"Mendelian Randomization Studies in Stroke: Exploration of Risk Factors and Drug Targets With Human Genetic Data","volume":"52","author":"Marios","year":"2021","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ultsonch.2026.108000_b0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13020-025-01125-x","article-title":"Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K\/AKT\/NF-\u03baB signaling pathway","volume":"20","author":"Li","year":"2025","journal-title":"Chin. Med."},{"key":"10.1016\/j.ultsonch.2026.108000_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.121020","article-title":"Integration of proteomics, network pharmacology and Mendelian randomization: Revealing key targets and mechanisms of Huoluo Xiaoling Pellet in improving knee osteoarthritis","volume":"358","author":"Liu","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ultsonch.2026.108000_b0100","first-page":"1400","article-title":"Green and efficient extraction of rutin from tartary buckwheat hull by using natural deep eutectic solvents","volume":"221","author":"Yao","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0105","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jpba.2016.11.049","article-title":"Deep eutectic solvents as green media for extraction of flavonoid glycosides and aglycones from Platycladi Cacumen","volume":"134","author":"Zhuang","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ultsonch.2026.108000_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2026.150149","article-title":"Optimized green extraction of flavonoids from Lycium barbarum leaves using betaine-ethylene glycol NADES: Mechanisms, identification, and bioactivity","volume":"523","author":"Yuan","year":"2026","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130562","article-title":"Novel extraction of polyphenols from sour cherry pomace using natural deep eutectic solvents - Ultrafast microwave-assisted NADES preparation and extraction","volume":"366","author":"Popovic","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122696","article-title":"NaDES as a green technological approach for the solubility improvement of BCS class II APIs: An insight into the molecular interactions","volume":"634","author":"Albertini","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ultsonch.2026.108000_b0125","article-title":"NADES-based microwave-assisted single-step extraction process for extracting bioactive compounds from Amomum subulatum Roxb.: A sustainable approach","volume":"494","author":"Nelson","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.147372","article-title":"Sustainable extraction and bioconversion of tea stems using NADES: Dual benefits in polyphenolic recovery and carbohydrates enzymatic hydrolysis","volume":"499","author":"Sun","year":"2026","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.138629","article-title":"Deep eutectic solvents for the extraction of polyphenols from food plants","volume":"444","author":"Akta\u015f","year":"2024","journal-title":"Food Chem."},{"issue":"9","key":"10.1016\/j.ultsonch.2026.108000_b0140","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"Urmo","year":"2021","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.ultsonch.2026.108000_b0145","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Egil","year":"2021","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.ultsonch.2026.108000_b0150","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41588-024-02044-7","article-title":"A scalable variational inference approach for increased mixed-model association power","volume":"57","author":"Hrushikesh","year":"2025","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.ultsonch.2026.108000_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"George Davey","year":"2003","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.ultsonch.2026.108000_b0160","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.ultsonch.2026.108000_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112950","article-title":"Pharmacokinetic-pharmacodynamic modeling analysis for hydroxysafflor yellow A-calycosin in compatibility in normal and cerebral ischemic rats: A comparative study","volume":"150","author":"Chen","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ultsonch.2026.108000_b0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1142\/S0192415X19500034","article-title":"Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70\/Bcl-2- and HSP70\/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats","volume":"47","author":"Cheng","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ultsonch.2026.108000_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154111","article-title":"Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1\/Parkin-dependent mitophagy","volume":"101","author":"Mao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ultsonch.2026.108000_b0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2014.03.028","article-title":"Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia\/reperfusion rats: involvement of inhibition of TLR4\/peroxiredoxin 6 signaling","volume":"71","author":"Kuang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ultsonch.2026.108000_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1230861","article-title":"Anti-platelet aggregation activities of different grades of Angelica sinensis and their therapeutic mechanisms in rats with blood deficiency: insights from metabolomics and lipidomics analyses","volume":"14","author":"Shen","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ultsonch.2026.108000_b0190","article-title":"Simultaneous Determination of Eight Chemical Components in Angelicae Sinensis Radix and Its Herbal Products by QAMS","volume":"2021","author":"Yu","year":"2021","journal-title":"J. Anal. Methods Chem."},{"issue":"2","key":"10.1016\/j.ultsonch.2026.108000_b0195","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.chroma.2005.01.082","article-title":"Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis","volume":"1068","author":"Lu","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ultsonch.2026.108000_b0200","first-page":"31","article-title":"Natural Deep Eutectic Solvents and Their Applications in Biotechnology","volume":"168","author":"Zhen","year":"2018","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.ultsonch.2026.108000_b0205","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1104096","article-title":"Applications for natural deep eutectic solvents in Chinese herbal medicines","volume":"13","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.ultsonch.2026.108000_b0210","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.tiv.2014.12.017","article-title":"Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro","volume":"29","author":"Val\u00e9rian","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ultsonch.2026.108000_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2023.106344","article-title":"Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities","volume":"94","author":"Song","year":"2023","journal-title":"Ultrason. Sonochem."},{"issue":"Pt 1","key":"10.1016\/j.ultsonch.2026.108000_b0220","article-title":"Natural deep eutectic solvents (NADES): dual functionality in the extraction and stabilization of polyphenols, terpenoids and nitrogen compounds","volume":"525","author":"Valles-Salas","year":"2026","journal-title":"Food Chem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0225","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aca.2012.12.019","article-title":"Natural deep eutectic solvents as new potential media for green technology","volume":"766","author":"Dai","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ultsonch.2026.108000_b0230","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jconrel.2019.09.019","article-title":"Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems","volume":"316","author":"Zainal-Abidin","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ultsonch.2026.108000_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2023.106640","article-title":"Sustainable ultrasound-assisted extraction of Polygonatum sibiricum saponins using ionic strength-responsive natural deep eutectic solvents","volume":"100","author":"Zhang","year":"2023","journal-title":"Ultrason. Sonochem."},{"issue":"4","key":"10.1016\/j.ultsonch.2026.108000_b0240","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.ultsonch.2010.11.023","article-title":"Applications of ultrasound in food technology: Processing, preservation and extraction","volume":"18","author":"Chemat","year":"2011","journal-title":"Ultrason. Sonochem."},{"issue":"22","key":"10.1016\/j.ultsonch.2026.108000_b0245","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.3390\/foods14223884","article-title":"Exploring Bioactive Compounds from Fruit and Vegetable By-Products with Potential for Food and Nutraceutical Applications","volume":"14","author":"Carvalho","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.ultsonch.2026.108000_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2023.106646","article-title":"A comprehensive review of ultrasonic assisted extraction (UAE) for bioactive components: Principles, advantages, equipment, and combined technologies","volume":"101","author":"Shen","year":"2023","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2026.107952","article-title":"Ultrasound-assisted extraction of flavonoids from Artemisia argyi folium using deep eutectic solvents: optimization, mechanistic characterization, bioactivity evaluation, and strawberry preservation applications","volume":"132","author":"Bao","year":"2026","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107500","article-title":"Ultrasound-assisted extraction with deep eutectic solvents for valorization of agro-food waste: A sustainable and eco-friendly approach","volume":"120","author":"Xu","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ultsonch.2026.108000_b0265","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodchem.2015.03.123","article-title":"Tailoring properties of natural deep eutectic solvents with water to facilitate their applications","volume":"187","author":"Dai","year":"2015","journal-title":"Food Chem."},{"issue":"33","key":"10.1016\/j.ultsonch.2026.108000_b0270","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1002\/anie.201702486","article-title":"The Effect of Water upon Deep Eutectic Solvent Nanostructure: An Unusual Transition from Ionic Mixture to Aqueous Solution","volume":"56","author":"Hammond","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ultsonch.2026.108000_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2024.106914","article-title":"Recent advances in the implementation of ultrasound technology for the extraction of essential oils from terrestrial plant materials: A comprehensive review","volume":"107","author":"Khalid","year":"2024","journal-title":"Ultrason. Sonochem."},{"issue":"1","key":"10.1016\/j.ultsonch.2026.108000_b0280","doi-asserted-by":"crossref","first-page":"20265","DOI":"10.1038\/s41598-023-47615-6","article-title":"Application of response surface methodology and quantitative NMR for the optimum extraction, characterization, and quantitation of Antrodia cinnamomea triterpenoids","volume":"13","author":"Li","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ultsonch.2026.108000_b0285","article-title":"Artificial Neural Networks (ANNs) and Response Surface Methodology (RSM) Approach for Modelling the Optimization of Chromium (VI) Reduction by Newly Isolated Acinetobacter radioresistens Strain NS-MIE from Agricultural Soil","volume":"2019","author":"Nur Syuhadah","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ultsonch.2026.108000_b0290","article-title":"Application of an Artificial Intelligence System Recognition Based on the Deep Neural Network Algorithm","volume":"2022","author":"Zhang","year":"2022","journal-title":"Comput. Intell. Neurosci."},{"key":"10.1016\/j.ultsonch.2026.108000_b0295","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1935272","article-title":"An Improved Particle Swarm Optimization Algorithm and Its Application to the Extreme Value Optimization Problem of Multivariable Function","volume":"2022","author":"Cai","year":"2022","journal-title":"Comput. Intell. Neurosci."},{"issue":"2","key":"10.1016\/j.ultsonch.2026.108000_b0300","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/e24020283","article-title":"Learning Competitive Swarm Optimization","volume":"24","author":"Bo\u017cena","year":"2022","journal-title":"Entropy (Basel)"},{"issue":"43","key":"10.1016\/j.ultsonch.2026.108000_b0305","article-title":"Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and ROR\u03b3t to Alleviate Depression-Associated Neuroinflammation","volume":"12","author":"Guo","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"10.1016\/j.ultsonch.2026.108000_b0310","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/cns.14060","article-title":"Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4\/NF-\u03baB pathway","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ultsonch.2026.108000_b0315","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainres.2013.05.009","article-title":"Z-ligustilide activates the Nrf2\/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro","volume":"1520","author":"Peng","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.ultsonch.2026.108000_b0320","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3389\/fphar.2020.00979","article-title":"Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K\/Akt Pathway","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."}],"container-title":["Ultrasonics Sonochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726002658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350417726002658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:19:48Z","timestamp":1787638788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1350417726002658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":64,"alternative-id":["S1350417726002658"],"URL":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.108000","relation":{},"ISSN":["1350-4177"],"issn-type":[{"value":"1350-4177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experiment-confirmed machine learning optimization of NADES extraction with ultrasound assistance and Mendelian randomization evidence on antioxidant effects of ferulic acid and ligustilide from Angelicae Sinensis Radix","name":"articletitle","label":"Article Title"},{"value":"Ultrasonics Sonochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ultsonch.2026.108000","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108000"}}