{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:37:06Z","timestamp":1793223426019,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.urology.2004.05.031","type":"journal-article","created":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T18:48:22Z","timestamp":1098384502000},"page":"809-813","source":"Crossref","is-referenced-by-count":57,"title":["Identification of interstitial cells of Cajal in human urinary bladder: Concept of vesical pacemaker"],"prefix":"10.1016","volume":"64","author":[{"given":"Ahmed","family":"Shafik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat","family":"El-Sibai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Shafik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Shafik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2004.05.031_bib1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF00184111","article-title":"Study of the electromechanical activity of the urinary bladder: experimental study","volume":"12","author":"Shafik","year":"1994","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2004.05.031_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000282691","article-title":"Electrovesicography in interstitial cystitis","volume":"54","author":"Shafik","year":"1995","journal-title":"Urol Int"},{"key":"10.1016\/j.urology.2004.05.031_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3109\/08941939609025865","article-title":"Electrovesicogram in the neurogenic bladder","volume":"9","author":"Shafik","year":"1996","journal-title":"J Invest Surg"},{"key":"10.1016\/j.urology.2004.05.031_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF01907073","article-title":"Electrovesicogram in stress urinary incontinence: a preliminary study","volume":"7","author":"Shafik","year":"1996","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.urology.2004.05.031_bib5","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/j.1476-5381.1996.tb15584.x","article-title":"Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra","volume":"118","author":"Hashitani","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.urology.2004.05.031_bib6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1469-7793.1999.459ae.x","article-title":"Spontaneous and neurally-activated depolarizations in smooth muscle cells of guinea-pig urethra","volume":"514","author":"Hashitani","year":"1999","journal-title":"J Physiol"},{"key":"10.1016\/j.urology.2004.05.031_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/dev.116.2.369","article-title":"Requirement of c-kit for development of intestinal pacemaker system","volume":"116","author":"Maeda","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.urology.2004.05.031_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/335088a0","article-title":"The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse (W) locus","volume":"335","author":"Chabot","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.urology.2004.05.031_bib9","first-page":"602","article-title":"Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bed-side. 1","volume":"251","author":"Ward","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.urology.2004.05.031_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1365-2982.2001.00269.x","article-title":"Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle?","volume":"13","author":"Daniel","year":"2001","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.urology.2004.05.031_bib11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1113\/jphysiol.1993.sp019868","article-title":"Electrical coupling of circular muscle to longitudinal muscle and interstitial cells of Cajal in canine colon","volume":"470","author":"Lui","year":"1993","journal-title":"J Physiol"},{"key":"10.1016\/j.urology.2004.05.031_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0016-5085(92)91784-2","article-title":"Ultrastructure of interstitial cells of Cajal associated with deep muscular plexus of human small intestine","volume":"102","author":"Rumessen","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.urology.2004.05.031_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1469-7793.2000.t01-2-00359.x","article-title":"Specialized pacemaking cells in the rabbit urethra","volume":"526","author":"Sergeant","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.urology.2004.05.031_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0022-5347(05)64752-0","article-title":"Kit positive cells in the guinea pig bladder","volume":"168","author":"McCloskey","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2004.05.031_bib15","first-page":"925","article-title":"Identification of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract","volume":"284","author":"Pezzone","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.urology.2004.05.031_bib16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/bjs.1800840406","article-title":"Role of interstitial cells of Cajal in the control of gut motility","volume":"84","author":"Hagger","year":"1997","journal-title":"Br J Surg"},{"key":"10.1016\/j.urology.2004.05.031_bib17","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1177\/42.11.7523489","article-title":"Expression of c-kit and kit ligand proteins in normal human tissues","volume":"42","author":"Lammie","year":"1994","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.urology.2004.05.031_bib18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/(SICI)1097-0029(19991201)47:5<325::AID-JEMT4>3.0.CO;2-C","article-title":"Receptors in interstitial cells of Cajal: identification and possible physiological roles","volume":"47","author":"Vannucchi","year":"1999","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.urology.2004.05.031_bib19","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/gast.1996.v111.pm8690216","article-title":"A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract","volume":"111","author":"Sanders","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.urology.2004.05.031_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s004410051231","article-title":"Intimate relationship between interstitial cells of Cajal and enteric nerves in guinea pig small intestine","volume":"295","author":"Wang","year":"1999","journal-title":"Cell Tiss Res"},{"key":"10.1016\/j.urology.2004.05.031_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4522(95)00453-X","article-title":"Distribution of nitric oxide synthase-immunoreactive nerves and identification of cellular targets of nitric oxide in guinea-pig and human urinary bladder by CGMP immunohistochemistry","volume":"71","author":"Smet","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.urology.2004.05.031_bib22","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0016-5085(96)70057-4","article-title":"Interstitial cells of Cajal in human colon and in Hirschsprung's disease","volume":"111","author":"Vanderwinden","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.urology.2004.05.031_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1113\/jphysiol.1994.sp020343","article-title":"Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine","volume":"480","author":"Ward","year":"1994","journal-title":"J Physiol"},{"key":"10.1016\/j.urology.2004.05.031_bib24","first-page":"332","article-title":"Deficiency of c-kit cells in patients with a myopathic form of chronic idiopathic interstitial pseudo-obstruction","volume":"92","author":"Isozaki","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.urology.2004.05.031_bib25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0016-5085(95)90333-X","article-title":"Disturbed intestinal movement, bile reflux to the stomach and deficiency of c-kit expressing cells in Ws\/Ws mutant rats","volume":"109","author":"Isozaki","year":"1995","journal-title":"Gastroenterology"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429504006831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429504006831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T19:58:25Z","timestamp":1624737505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429504006831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0090429504006831"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2004.05.031","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}