{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:56:26Z","timestamp":1780944986004,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.urology.2006.01.050","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T21:27:50Z","timestamp":1153171670000},"page":"148-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Front pattern of invasion in squamous cell carcinoma of the penis: New prognostic factor for predicting risk of lymph node metastases"],"prefix":"10.1016","volume":"68","author":[{"given":"Gustavo Cardoso","family":"Guimar\u00e3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Sousa Madeira","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stenio","family":"de C\u00e1ssio Zequi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Lima","family":"de Oliveira Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lopes","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Werneck","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2006.01.050_bib1","unstructured":"Gloeckler-Reis LA, Hankey BF, and Edwards BK: Cancer Statistic Review 1973\u20131987. Publication No. 90-2789. Bethesda, National Institutes of Health, 1990."},{"key":"10.1016\/j.urology.2006.01.050_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0022-5347(17)64082-5","article-title":"Epidermoid carcinoma of the penis","volume":"91","author":"Beggs","year":"1964","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib3","first-page":"143","article-title":"Treatment of carcinoma of the penis","volume":"12","author":"Puras","year":"1978","journal-title":"Proc Kimbrough Urol Semin"},{"key":"10.1016\/j.urology.2006.01.050_bib4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/1097-0142(1955)8:2<371::AID-CNCR2820080216>3.0.CO;2-#","article-title":"Carcinoma of the penis","volume":"8","author":"Staubitz","year":"1955","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2006.01.050_bib5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/1097-0142(197710)40:4<1697::AID-CNCR2820400445>3.0.CO;2-T","article-title":"Surgical treatment of penile carcinoma","volume":"40","author":"Wajsman","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2006.01.050_bib6","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/1097-0142(19820515)49:10<2185::AID-CNCR2820491034>3.0.CO;2-M","article-title":"Carcinoma of the penis","volume":"49","author":"Narayama","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2006.01.050_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0090-4295(91)80171-3","article-title":"Penile carcinoma","volume":"38","author":"Young","year":"1991","journal-title":"Urology"},{"key":"10.1016\/j.urology.2006.01.050_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jso.2930520114","article-title":"Carcinoma of the penis","volume":"52","author":"Kamat","year":"1993","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.urology.2006.01.050_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0022-5347(17)36126-8","article-title":"Squamous cell carcinoma of the penis. III. Treatment of regional lymph nodes","volume":"149","author":"Horenblas","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib10","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0022-5347(17)35222-9","article-title":"Surgical treatment of invasive squamous cell carcinoma of the penis","volume":"151","author":"Ornellas","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib11","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0022-5347(01)65471-5","article-title":"Prognostic factors in carcinoma of penis","volume":"156","author":"Lopes","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0094-0143(21)00170-1","article-title":"Role of lymphadenectomy in carcinoma of the penis","volume":"7","author":"Catalona","year":"1980","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.urology.2006.01.050_bib13","series-title":"Adult and Pediatric Urology","first-page":"1462","article-title":"Benign and malignant lesions of the penis","author":"Sufrin","year":"1987"},{"key":"10.1016\/j.urology.2006.01.050_bib14","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<2099::AID-CNCR20>3.0.CO;2-P","article-title":"Unreliability of modified inguinal lymphadenectomy for clinical staging of penile carcinoma","volume":"77","author":"Lopes","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2006.01.050_bib15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/1097-0142(197702)39:2<456::AID-CNCR2820390214>3.0.CO;2-I","article-title":"An approach for the treatment of the penile carcinoma","volume":"39","author":"Cabanas","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2006.01.050_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0022-5347(05)67982-7","article-title":"Detection of occult metastasis in squamous cell carcinoma of the penis using a dynamic sentinel node procedure","volume":"163","author":"Horenblas","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0022-5347(05)64835-5","article-title":"Dynamic sentinel node biopsy for penile cancer","volume":"168","author":"Tanis","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.eururo.2004.11.018","article-title":"Dynamic sentinel node biopsy in penile carcinoma","volume":"47","author":"Kroon","year":"2005","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-5347(05)64836-7","article-title":"p53 as a new prognostic factor for lymph node metastasis in penile carcinoma","volume":"168","author":"Lopes","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib20","first-page":"229","article-title":"Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinoma","volume":"95","author":"Anneroth","year":"1987","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.urology.2006.01.050_bib21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1600-0714.1989.tb01339.x","article-title":"New malignance grading is a better prognostic indicator than Broder\u2019s grading in oral squamous cell carcinoma","volume":"18","author":"Bryne","year":"1989","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.urology.2006.01.050_bib22","series-title":"Penis, in AJCC Cancer Staging Handbook","first-page":"331","year":"2002"},{"key":"10.1016\/j.urology.2006.01.050_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0090-4295(98)00137-X","article-title":"Deoxyribonucleic acid flow cytometry and traditional pathologic variables in invasive penile carcinoma assessment of prognostic significance","volume":"52","author":"Hall","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.urology.2006.01.050_bib24","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/S0022-5347(17)39130-9","article-title":"The role of ilioinguinal lymphadenectomy and significance of histological differentiation in treatment of carcinoma of the penis","volume":"142","author":"Fraley","year":"1989","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib25","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0022-5347(05)66450-6","article-title":"Tumor stage, vascular invasion and the percentage of poorly differentiated cancer","volume":"156","author":"Slaton","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib26","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0022-5347(17)44281-9","article-title":"Penile cancer","volume":"137","author":"Srinivas","year":"1987","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib27","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/1097-0142(19850401)55:7<1618::AID-CNCR2820550735>3.0.CO;2-R","article-title":"Cancer of the penis","volume":"55","author":"Fraley","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2006.01.050_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000474736","article-title":"Corpus cavernosum invasion and tumor grade in the prediction of lymph node condition in penile carcinoma","volume":"22","author":"Solsona","year":"1992","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib29","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/S0022-5347(05)66337-9","article-title":"Prospective validation of the association of local tumor stage and grades as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal nodes","volume":"165","author":"Solsona","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib30","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0022-5347(17)38068-0","article-title":"Squamous cell carcinoma of the penis","volume":"146","author":"Horenblas","year":"1991","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2006.01.050_bib31","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0022-5347(17)35221-7","article-title":"Squamous cell carcinoma of the penis. IV. Prognostic factors of survival: analysis of Tumor, Nodes and Metastasis classification system","volume":"151","author":"Horenblas","year":"1994","journal-title":"J Urol"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429506001208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429506001208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:44:52Z","timestamp":1758764692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429506001208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0090429506001208"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2006.01.050","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Front pattern of invasion in squamous cell carcinoma of the penis: New prognostic factor for predicting risk of lymph node metastases","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2006.01.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}