{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:17:54Z","timestamp":1791271074683,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK 064880"],"award-info":[{"award-number":["DK 064880"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.urology.2007.12.091","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T04:30:04Z","timestamp":1212726604000},"page":"1085-1090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Urinary Tract Infection and Inflammation at Onset of Interstitial Cystitis\/Painful Bladder Syndrome"],"prefix":"10.1016","volume":"71","author":[{"given":"John W.","family":"Warren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Langenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patty","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2007.12.091_bib1","series-title":"Incontinence, Third International Consultation","first-page":"1455","article-title":"Painful bladder syndrome (including interstitial cystitis)","author":"Hanno","year":"2005"},{"key":"10.1016\/j.urology.2007.12.091_bib2","doi-asserted-by":"crossref","first-page":"S216","DOI":"10.1093\/clind\/15.Supplement_1.S216","article-title":"Evaluation of new anti-infective drugs for the treatment of urinary tract infection","volume":"15","author":"Rubin","year":"1992","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.urology.2007.12.091_bib3","series-title":"Interstitial Cystitis","first-page":"29","article-title":"Epidemiology of interstitial cystitis","author":"Held","year":"1990"},{"key":"10.1016\/j.urology.2007.12.091_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s00192-004-1129-9","article-title":"Different clinical presentation of interstitial cystitis syndrome","volume":"15","author":"Porru","year":"2004","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"10.1016\/j.urology.2007.12.091_bib5","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/S0022-5347(05)65517-6","article-title":"How do patients with interstitial cystitis present?","volume":"166","author":"Driscoll","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2007.12.091_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1047-2797(00)00072-7","article-title":"Urinary tract infection: self-reported incidence and associated costs","volume":"10","author":"Foxman","year":"2000","journal-title":"Ann Epidemiology"},{"key":"10.1016\/j.urology.2007.12.091_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1525-1497.1999.05398.x","article-title":"Variation by specialty in the treatment of urinary tract infection in women","volume":"14","author":"Wigton","year":"1999","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.urology.2007.12.091_bib8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.urology.2006.03.036","article-title":"Dysuria on onset of interstitial cystitis\/painful bladder syndrome in women","volume":"68","author":"Warren","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.urology.2007.12.091_bib9","series-title":"Interstitial Cystitis","first-page":"3","article-title":"Interstitial cystitis: an introduction to the problem","author":"Wein","year":"1990"},{"key":"10.1016\/j.urology.2007.12.091_bib10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1309\/C69RW1BT7E4QAFPV","article-title":"The use of urinary dipstick tests to exclude urinary tract infection: a review of the literature","volume":"126","author":"St. John","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.urology.2007.12.091_bib11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1086\/315827","article-title":"Risk factors for recurrent urinary tract infection in young women","volume":"182","author":"Scholes","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.urology.2007.12.091_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2490-4-4","article-title":"The urine dipstick test used to rule out infections: a meta-analysis of the accuracy","volume":"4","author":"Deville","year":"2004","journal-title":"BMC Urol"},{"key":"10.1016\/j.urology.2007.12.091_bib13","first-page":"582","article-title":"The diagnostic accuracy of rapid dipstick tests to predict urinary tract infection","volume":"96","author":"Hurlbut","year":"1991","journal-title":"Clin Microb Infect Dis"},{"key":"10.1016\/j.urology.2007.12.091_bib14","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1001\/jama.287.20.2701","article-title":"Does this woman have an acute uncomplicated urinary tract infection?","volume":"287","author":"Bent","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.urology.2007.12.091_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0090-4295(78)90286-8","article-title":"Interstitial cystitis: early diagnosis, pathology, and treatment","volume":"12","author":"Messing","year":"1978","journal-title":"Urology"},{"issue":"5A suppl","key":"10.1016\/j.urology.2007.12.091_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0090-4295(99)80334-3","article-title":"The Interstitial Cystitis Data Base Study: concepts and preliminary baseline descriptive statistics","volume":"49","author":"Simon","year":"1997","journal-title":"Urology"},{"issue":"5A suppl","key":"10.1016\/j.urology.2007.12.091_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0090-4295(99)80333-1","article-title":"The Interstitial Cystitis Symptom Index and problem index","volume":"49","author":"O'Leary","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.urology.2007.12.091_bib18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM198008213030801","article-title":"Causes of the acute urethral syndrome in women","volume":"303","author":"Stamm","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urology.2007.12.091_bib19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1086\/427507","article-title":"Infectious Diseases Society of America Guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults","volume":"40","author":"Nicolle","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.urology.2007.12.091_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/JCM.42.2.753-758.2004","article-title":"Viable but nonculturable bacteria are present in mouse and human urine specimens","volume":"42","author":"Anderson","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.urology.2007.12.091_bib21","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/IAI.69.7.4572-4579.2001","article-title":"Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection","volume":"69","author":"Mulvey","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.urology.2007.12.091_bib22","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1172\/JCI200320365","article-title":"The application of biofilm science to the study and control of chronic bacterial infections","volume":"112","author":"Costerton","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.urology.2007.12.091_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/01.ju.0000161605.14804.a9","article-title":"Absence of bacterial and viral DNA in bladder biopsies from patients with interstitial cystitis\/chronic pelvic pain syndrome","volume":"174","author":"Al-Hadithi","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2007.12.091_bib24","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/S0022-5347(01)68237-5","article-title":"Detection of eubacteria in interstitial cystitis by 16S rDNA amplification","volume":"158","author":"Heritz","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2007.12.091_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0090-4295(95)80009-3","article-title":"A prospective study of microorganisms in urine and bladder biopsies from interstitial cystitis patients and controls","volume":"45","author":"Keay","year":"1995","journal-title":"Urology"},{"key":"10.1016\/j.urology.2007.12.091_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0090-4295(01)01120-7","article-title":"Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs","volume":"57","author":"Warren","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.urology.2007.12.091_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.urology.2003.08.027","article-title":"Prevalence of interstitial cystitis in first-degree relatives of patients with interstitial cystitis","volume":"63","author":"Warren","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2007.12.091_bib28","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0022-5347(01)65438-7","article-title":"Decreased 3H-thymidine incorporation by human bladder epithelial cells following exposure to urine from interstitial cystitis patients","volume":"156","author":"Keay","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2007.12.091_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0306-9877(98)90260-2","article-title":"A hypothesis for the etiology of interstitial cystitis based upon inhibition of bladder epithelial repair","volume":"51","author":"Keay","year":"1998","journal-title":"J Med Hypotheses"},{"issue":"suppl A","key":"10.1016\/j.urology.2007.12.091_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0090-4295(01)01166-9","article-title":"Biopsy features are associated with primary symptoms in interstitial cystitis: results from the Interstitial Cystitis Database Study","volume":"57","author":"Tomaszewski","year":"2001","journal-title":"Urology"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429507026878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429507026878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:49:08Z","timestamp":1758764948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429507026878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0090429507026878"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2007.12.091","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary Tract Infection and Inflammation at Onset of Interstitial Cystitis\/Painful Bladder Syndrome","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2007.12.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}