{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:43:26Z","timestamp":1791420206236,"version":"4.3.3"},"reference-count":17,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.urology.2008.01.051","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T01:38:40Z","timestamp":1209865120000},"page":"1109-1113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Metabolic Syndrome in Men with Klinefelter's Syndrome"],"prefix":"10.1016","volume":"71","author":[{"given":"Tomomoto","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2008.01.051_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","volume":"88","author":"Bojesen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.urology.2008.01.051_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/adc.80.2.192","article-title":"Long-term outcome in children of sex chromosome abnormalities","volume":"80","author":"Ratcliffe","year":"1999","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.urology.2008.01.051_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<363::AID-PD79>3.0.CO;2-O","article-title":"47,XXY (Klinefelter syndrome) and 47,XYY: estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling","volume":"17","author":"Abramsky","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.urology.2008.01.051_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/jech.39.4.330","article-title":"Causes of death in X chromatin positive males (Klinefelter's syndrome)","volume":"39","author":"Price","year":"1985","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.urology.2008.01.051_bib5","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1210\/jcem-29-8-1062","article-title":"Frequency of diabetes mellitus in patients with Klinefelter's syndrome of different chromosome constitutions and the XYY syndrome","volume":"29","author":"Nielsen","year":"1969","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.urology.2008.01.051_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s001980170158","article-title":"Bone mineral density and quantitative ultrasound parameters in patients with Klinefelter's syndrome after long-term testosterone substitution","volume":"12","author":"van den Bergh","year":"2001","journal-title":"Osteop Int"},{"key":"10.1016\/j.urology.2008.01.051_bib7","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2337\/dc06-0145","article-title":"The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism","volume":"29","author":"Bojesen","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.urology.2008.01.051_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(04)16678-6","article-title":"Klinefelter's syndrome","volume":"364","author":"Lanfranco","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.urology.2008.01.051_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2265.1975.tb01547.x","article-title":"Hormonal studies in Klinefelter's syndrome","volume":"4","author":"Wang","year":"1975","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.urology.2008.01.051_bib10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.7326\/0003-4819-117-10-871","article-title":"Androgens, lipids and cardiovascular risk","volume":"117","author":"Plymate","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.urology.2008.01.051_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0140-6736(75)92376-4","article-title":"Plasma high-density-lipoprotein concentration and development of ischemic heart disease","volume":"1","author":"Miller","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.urology.2008.01.051_bib12","first-page":"991","article-title":"The effects of testosterone treatment on body composition and metabolism in middle-aged obese men","volume":"16","author":"Marin","year":"1992","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.urology.2008.01.051_bib13","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1210\/jcem.86.3.7453","article-title":"Tissue-specific dysregulation of cortisol metabolism in human obesity","volume":"86","author":"Rask","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.urology.2008.01.051_bib14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0140-6736(00)02763-X","article-title":"Early androgenetic alopecia as a marker of insulin resistance [letter]","volume":"356","author":"Matilainen","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.urology.2008.01.051_bib15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/sj.ijo.0801183","article-title":"Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men","volume":"24","author":"Tsai","year":"2000","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.urology.2008.01.051_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2265.1992.tb02910.x","article-title":"Osteoporosis and Klinefelter's syndrome","volume":"36","author":"Horowitz","year":"1992","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.urology.2008.01.051_bib17","first-page":"534","article-title":"Insulin resistance in patients with Klinefelter's syndrome and idiopathic gonadotropin deficiency","volume":"97","author":"Pei","year":"1998","journal-title":"J Formos Med Assoc"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429508001325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429508001325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:48:12Z","timestamp":1758764892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429508001325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0090429508001325"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2008.01.051","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic Syndrome in Men with Klinefelter's Syndrome","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2008.01.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}