{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:18:11Z","timestamp":1786997891549,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK 066138"],"award-info":[{"award-number":["DK 066138"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P50-GM-53789-09"],"award-info":[{"award-number":["P50-GM-53789-09"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006663","name":"National Institute on Disability and Rehabilitation Research","doi-asserted-by":"publisher","award":["H133E070024"],"award-info":[{"award-number":["H133E070024"]}],"id":[{"id":"10.13039\/100006663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.urology.2008.07.031","type":"journal-article","created":{"date-parts":[[2008,10,11]],"date-time":"2008-10-11T14:00:33Z","timestamp":1223733633000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Multiplex Analysis of Urinary Cytokine Levels in Rat Model of Cyclophosphamide-induced Cystitis"],"prefix":"10.1016","volume":"73","author":[{"given":"Marc C.","family":"Smaldone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Vodovotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Philips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Chancellor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2008.07.031_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.urology.2006.03.084","article-title":"The role of the urinary epithelium in the pathogenesis of interstitial cystitis\/prostatitis\/urethritis","volume":"69","author":"Parsons","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.urology.2008.07.031_bib2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-5347(01)61948-7","article-title":"The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis database study","volume":"161","author":"Hanno","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.urology.2003.08.024","article-title":"Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor in men with interstitial cystitis versus chronic pelvic pain syndrome","volume":"63","author":"Keay","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.urology.2008.07.031_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/01.ju.0000146466.71311.ab","article-title":"Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis?","volume":"173","author":"Erickson","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0090-4295(01)01007-X","article-title":"Assessment of murine bladder permeability with fluorescein: Validation with cyclophosphamide and protamine","volume":"58","author":"Eichel","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.urology.2008.07.031_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF00240958","article-title":"Cyclophosphamide cystitis as a model of visceral pain in rats: Model elaboration and spinal structures involved as revealed by the expression of c-Fos and Krox-24 proteins","volume":"105","author":"Lanteri-Minet","year":"1995","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.urology.2008.07.031_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/00005392-200102000-00089","article-title":"Automated noninvasive measurement of cyclophosphamide-induced changes in murine voiding frequency and volume","volume":"165","author":"Wood","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/physiolgenomics.00117.2001","article-title":"Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis","volume":"9","author":"Malley","year":"2002","journal-title":"Physiol Genom"},{"key":"10.1016\/j.urology.2008.07.031_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2172-8-6","article-title":"Discriminators of mouse bladder response to intravesical bacillus Calmette-Gu\u00e9rin (BCG)","volume":"8","author":"Saban","year":"2007","journal-title":"BMC Immunol"},{"key":"10.1016\/j.urology.2008.07.031_bib10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0022-5347(05)64750-7","article-title":"Mast cell activation triggers a urothelial inflammatory response mediated by tumor necrosis factor-alpha","volume":"168","author":"Batler","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jchromb.2005.10.051","article-title":"Improved HPLC method for the simultaneous determination of allantoin, uric acid and creatinine in cattle urine","volume":"832","author":"George","year":"2006","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"10.1016\/j.urology.2008.07.031_bib12","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/01.ju.0000146272.80848.37","article-title":"Morphology and localization of interstitial cells in the guinea pig bladder: Structural relationships with smooth muscle and neurons","volume":"173","author":"Davidson","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/01.ju.0000102360.11785.d7","article-title":"Urodynamic and immunohistochemical evaluation of intravesical capsaicin delivery using thermosensitive hydrogel and liposomes","volume":"171","author":"Tyagi","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib14","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/S0022-5347(05)65005-7","article-title":"A comparison of multiple urine markers for interstitial cystitis","volume":"167","author":"Erickson","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0022-5347(01)64317-9","article-title":"Inflammatory cell types and clinical features of interstitial cystitis","volume":"158","author":"Erickson","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0022-5347(17)32594-6","article-title":"Interleukin-6 and interstitial cystitis","volume":"152","author":"Lotz","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib17","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0022-5347(01)69129-8","article-title":"In vivo models of interstitial cystitis","volume":"167","author":"Westropp","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1517\/14740338.6.2.183","article-title":"The safety profile of cyclophosphamide in multiple sclerosis therapy","volume":"6","author":"Perini","year":"2007","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.urology.2008.07.031_bib19","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1253\/circj.72.813","article-title":"Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer","volume":"72","author":"Chang","year":"2008","journal-title":"Circul J"},{"key":"10.1016\/j.urology.2008.07.031_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jnr.20612","article-title":"CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons","volume":"82","author":"Qin","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.urology.2008.07.031_bib21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuroscience.2006.06.045","article-title":"Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia","volume":"142","author":"Xie","year":"2006","journal-title":"Neurosciences"},{"key":"10.1016\/j.urology.2008.07.031_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00005392-199907000-00073","article-title":"Mast cells mediate the severity of experimental cystitis in mice","volume":"162","author":"Bjorling","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2008.07.031_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0090-4295(01)01129-3","article-title":"Mast cell involvement in interstitial cystitis: A review of human and experimental evidence","volume":"57","author":"Theoharides","year":"2001","journal-title":"Urology"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429508009047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429508009047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:50:45Z","timestamp":1758765045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429508009047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0090429508009047"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2008.07.031","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiplex Analysis of Urinary Cytokine Levels in Rat Model of Cyclophosphamide-induced Cystitis","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2008.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}