{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:35:40Z","timestamp":1761510940663,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.urology.2009.04.017","type":"journal-article","created":{"date-parts":[[2009,7,19]],"date-time":"2009-07-19T04:17:01Z","timestamp":1247977021000},"page":"223-228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Local and Sustained Release of FGF, IGF, and GH on Germ Cells in Unilateral Undescended Testis in Rats"],"prefix":"10.1016","volume":"75","author":[{"given":"Meltem","family":"Bingol-Kologlu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Berktug","family":"Bahad\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahsan","family":"Vargun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande","family":"\u0130lkay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Umit","family":"Bagr\u0131acik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Yolbakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"Guven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba","family":"Endogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Has\u0131rc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Dindar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2009.04.017_bib1","first-page":"6","article-title":"Importance of early postnatal germ cell maturation for fertility for cryptorchid males","volume":"55","author":"Hadziselimovic","year":"2001","journal-title":"Horm Res"},{"key":"10.1016\/j.urology.2009.04.017_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.urology.2005.01.017","article-title":"Fertility after cryptorchidism: epidemiology and other outcome studies","volume":"66","author":"Lee","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.urology.2009.04.017_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2164\/jandrol.106.000828","article-title":"Cryptorchidism and semen quality: a TEM and molecular study","volume":"28","author":"Moretti","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.urology.2009.04.017_bib4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00383-005-1382-0","article-title":"Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation","volume":"21","author":"Ong","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.urology.2009.04.017_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0090-4295(98)00415-4","article-title":"Restoration of spermatogenesis after scrotal replacement of experimentally cryptorchid rat testis: assessment of germ cell apoptosis and eNOS expression","volume":"53","author":"Zini","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.urology.2009.04.017_bib6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s003830050347","article-title":"Fertility and unilateral undescended testis in the rat model II","volume":"13","author":"Sirinivas","year":"1998","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.urology.2009.04.017_bib7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/0022-3468(92)90387-M","article-title":"The natural course of cryptorchidism in rats and the efficacy of orchidopexy or orchidectomy in its treatment before and after puberty","volume":"27","author":"Patkowski","year":"1992","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.urology.2009.04.017_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1262\/jrd.17073","article-title":"Effects of experimental cryptorchidism on sperm motility and testicular endocrinology in adult male rats","volume":"52","author":"Ren","year":"2006","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.urology.2009.04.017_bib9","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0022-3468(90)90380-R","article-title":"Secondary changes in the scrotal testis in experimental unilateral cryptorchidism","volume":"25","author":"Quinn","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.urology.2009.04.017_bib10","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0022-5347(05)64640-X","article-title":"Recovery of spermatogenesis by high dose gonadotropin-releasing hormone analogue treatment in rat cryptorchid testis after orchiopexy","volume":"168","author":"Udagawa","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2009.04.017_bib11","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0015-0282(16)58579-3","article-title":"Functional and cytologic features of the contralateral testis in cryptorchidism","volume":"66","author":"Foresta","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.urology.2009.04.017_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2605.1994.tb01206.x","article-title":"The value of quantitative DNA flow cytometry of testicular fine-needle aspirates in assessment of spermatogenesis: a study of 137 previously maldescended human testes","volume":"17","author":"Giwercman","year":"1994","journal-title":"Int J Androl"},{"key":"10.1016\/j.urology.2009.04.017_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1439-0264.2005.00651.x","article-title":"Expression and localization of growth factors and their receptors in the mammalian testis","volume":"34","author":"Abd-Elmaksoud","year":"2005","journal-title":"Anat Histol Embryol"},{"key":"10.1016\/j.urology.2009.04.017_bib14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1439-0264.2006.00689.x","article-title":"Immunohistochemical localization of insulin-like growth factor-I receptor (IGF-IR) in the developing and mature rat testes","volume":"35","author":"Yagci","year":"2006","journal-title":"Anat Histol Embryol"},{"key":"10.1016\/j.urology.2009.04.017_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1210\/en.2004-0485","article-title":"Stimulation of steroidogenesis in immature rat Leydig cells evoked by interleukin-1alpha is potentiated by growth hormone and insulin-like growth factors","volume":"146","author":"Colon","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.urology.2009.04.017_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1677\/JOE-07-0258","article-title":"Inactivation of the IGF-I receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I","volume":"194","author":"Froment","year":"2007","journal-title":"J Endocrinol"},{"key":"10.1016\/j.urology.2009.04.017_bib17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1210\/en.2006-0835","article-title":"Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development","volume":"148","author":"Col\u00f3n","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.urology.2009.04.017_bib18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/hep.510310308","article-title":"Insulin-like growth factor-I reverts testicular atrophy in rats with advanced cirrhosis","volume":"32","author":"Castilla-Cortazar","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.urology.2009.04.017_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1040-8428(00)00062-7","article-title":"Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis","volume":"34","author":"Par","year":"2000","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.urology.2009.04.017_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jpedsurg.2004.01.038","article-title":"The effects of local and sustained release of fibroblast growth factor on testicular blood flow and morphology in spermatic artery- and vein-ligated rats","volume":"39","author":"G\u00fcler","year":"2004","journal-title":"J Ped Surg"},{"key":"10.1016\/j.urology.2009.04.017_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1210\/er.2007-0028","article-title":"Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction","volume":"23","author":"Cotton","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.urology.2009.04.017_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1464-410X.1997.09825.x","article-title":"Determination of testicular function after torsion by DNA flow cytometry of serial fine-needle aspirates","volume":"79","author":"Carroll","year":"1997","journal-title":"Br J Urol"},{"key":"10.1016\/j.urology.2009.04.017_bib23","first-page":"2","article-title":"Testicular biopsy score count\u2014a new method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"10.1016\/j.urology.2009.04.017_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1524-475X.2007.00211.x","article-title":"Release of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing","volume":"15","author":"Liu","year":"2007","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.urology.2009.04.017_bib25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0142-9612(91)90107-L","article-title":"Controlled and modulated release of FGF-b","volume":"12","author":"Edelman","year":"1991","journal-title":"Biomaterials"},{"key":"10.1016\/j.urology.2009.04.017_bib26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0142-9612(00)00287-8","article-title":"EGF containing gelatin based wound dressings","volume":"22","author":"Ulubayram","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.urology.2009.04.017_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0015-0282(16)47735-6","article-title":"Deoxyribonucleic acid flow cytometry: a new modality for quantitative analysis of testicular biopsies","volume":"41","author":"Chan","year":"1984","journal-title":"Fertil Steril"},{"key":"10.1016\/j.urology.2009.04.017_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0303-7207(88)90088-3","article-title":"Insulin-like growth factor-I (IGF-I) receptors on Sertoli cells from immature rats and age dependent testicular binding of IGF-I and insulin","volume":"55","author":"Oonk","year":"1988","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.urology.2009.04.017_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/joe.0.1260193","article-title":"Pubertal development and testicular function in the male growth hormone-deficient rat","volume":"126","author":"Bartlett","year":"1990","journal-title":"J Endocrinol"},{"key":"10.1016\/j.urology.2009.04.017_bib30","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1210\/endo.140.4.6661","article-title":"Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors","volume":"140","author":"Kansaki","year":"1999","journal-title":"Endocrinology"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429509005019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429509005019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:51:51Z","timestamp":1758765111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429509005019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0090429509005019"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2009.04.017","relation":{},"ISSN":["0090-4295"],"issn-type":[{"type":"print","value":"0090-4295"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Local and Sustained Release of FGF, IGF, and GH on Germ Cells in Unilateral Undescended Testis in Rats","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2009.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}