{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:29Z","timestamp":1791644069791,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.urology.2011.09.031","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T03:27:04Z","timestamp":1321500424000},"page":"145-149","source":"Crossref","is-referenced-by-count":45,"title":["On-demand Tramadol Hydrochloride Use in Premature Ejaculation Treatment"],"prefix":"10.1016","volume":"79","author":[{"given":"Mehmet","family":"Kaynar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozcan","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Yurdakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2011.09.031_bib1","first-page":"365","article-title":"Premature ejaculation","volume":"26","author":"Bejma","year":"2007","journal-title":"Am Urol Assoc Update Series"},{"key":"10.1016\/j.urology.2011.09.031_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1464-410X.2007.07051.x","article-title":"A review of the current status of topical treatments for premature ejaculation","volume":"100","author":"Morales","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2011.09.031_bib3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.eururo.2006.07.004","article-title":"The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking","volume":"51","author":"Porst","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2011.09.031_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/00926239308404371","article-title":"Some clinical and psychometric characteristics of primary and secondary premature ejaculators","volume":"19","author":"Cooper","year":"1993","journal-title":"J Sex Marital Ther"},{"key":"10.1016\/j.urology.2011.09.031_bib5","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.juro.2006.10.044","article-title":"Correlates to the clinical diagnosis of premature ejaculation: results from a large observational study of men and their partners","volume":"177","author":"Rosen","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2011.09.031_bib6","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/j.1743-6109.2008.00901.x","article-title":"An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation","volume":"5","author":"McMahon","year":"2008","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2011.09.031_bib7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1476-5381.1986.tb14580.x","article-title":"The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat","volume":"87","author":"R\u00e9nyi","year":"1986","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.urology.2011.09.031_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.ijir.3901172","article-title":"Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis","volume":"16","author":"Waldinger","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.urology.2011.09.031_bib9","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","article-title":"Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation","volume":"57","author":"Hatzimouratidis","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2011.09.031_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.jcp.0000195110.79027.3f","article-title":"Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study","volume":"26","author":"Safarinejad","year":"2006","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.urology.2011.09.031_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1213\/01.ANE.0000142121.24052.25","article-title":"The median effective dose of tramadol and morphine for postoperative patients: a study of interactions","volume":"100","author":"Marcou","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1016\/j.urology.2011.09.031_bib12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1745-7262.2008.00369.x","article-title":"Premature ejaculation: current and future treatments","volume":"10","author":"Gurkan","year":"2008","journal-title":"Asian J Androl"},{"key":"10.1016\/j.urology.2011.09.031_bib13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(06)69373-2","article-title":"Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation: integrated analysis of two randomized, double-blind, placebo-controlled trials","volume":"368","author":"Pryor","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.urology.2011.09.031_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/cne.20718","article-title":"Relevance of an evidence-based ejaculation time cut off point for neurobiological research of premature ejaculation","volume":"493","author":"Waldinger","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.urology.2011.09.031_bib15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1743-6109.2005.20353.x","article-title":"Premature ejaculation: an observational study of men and their partners","volume":"2","author":"Patrick","year":"2005","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2011.09.031_bib16","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.eururo.2007.10.015","article-title":"Premature ejaculation: results from a five-country European observational study","volume":"53","author":"Giuliano","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2011.09.031_bib17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1743-6109.2004.04033.x","article-title":"Self-reported premature ejaculation and aspects of sexual functioning and satisfaction","volume":"1","author":"Rowland","year":"2004","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2011.09.031_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.urology.2005.07.051","article-title":"Current and future pharmacotherapeutic strategies in treatment of premature ejaculation","volume":"67","author":"Mulhall","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.urology.2011.09.031_bib19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00345-004-0489-6","article-title":"Psychological treatment strategies for rapid ejaculation: rationale, practical aspects, and outcome","volume":"23","author":"Althof","year":"2005","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2011.09.031_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.ijir.3900630","article-title":"Assessment of as needed use of pharmacotherapy and pause-squeeze technique in premature ejeculation","volume":"13","author":"Abdel-Hamed","year":"2001","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.urology.2011.09.031_bib21","first-page":"37","article-title":"Emerging treatments for premature ejaculation: focus on dapoxetine","volume":"5","author":"Hellstrom","year":"2009","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.urology.2011.09.031_bib22","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2165\/00003495-200767120-00001","article-title":"Pharmacotherapy of mood disorders and treatment discontinuation","volume":"67","author":"Lader","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.urology.2011.09.031_bib23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1464-410X.2008.07719.x","article-title":"The pharmacological treatment of premature ejaculation","volume":"102","author":"Giuliano","year":"2008","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2011.09.031_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/0091270005284850","article-title":"Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation","volume":"46","author":"Modi","year":"2006","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.urology.2011.09.031_bib25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.eururo.2009.01.025","article-title":"Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries","volume":"55","author":"Buvat","year":"2009","journal-title":"Eur Urol"},{"issue":"1 Pt. 1","key":"10.1016\/j.urology.2011.09.031_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1743-6109.2009.01560.x","article-title":"Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine","volume":"7","author":"McMahon","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2011.09.031_bib27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2165\/00003495-200767040-00005","article-title":"Premature ejaculation: definition and drug treatment","volume":"67","author":"Waldinger","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.urology.2011.09.031_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1743-6109.2006.00424.x","article-title":"Tramadol HCl has promise in on-demand use to treat premature ejaculation","volume":"5","author":"Salem","year":"2008","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2011.09.031_bib29","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2165\/00003088-200443130-00004","article-title":"Clinical pharmacology of tramadol","volume":"43","author":"Grond","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.urology.2011.09.031_bib30","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1111\/j.1743-6109.2010.01789.x","article-title":"Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation","volume":"7","author":"Alghobary","year":"2010","journal-title":"J Sex Med"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429511024459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429511024459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T07:23:20Z","timestamp":1543389800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429511024459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0090429511024459"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2011.09.031","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13997956.15454056","asserted-by":"object"}]},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}