{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:06:26Z","timestamp":1781705186906,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.urology.2011.09.049","type":"journal-article","created":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T01:26:36Z","timestamp":1328318796000},"page":"484.e7-484.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Increased Cell Apoptosis of Urothelium Mediated by Inflammation in Interstitial Cystitis\/Painful Bladder Syndrome"],"prefix":"10.1016","volume":"79","author":[{"given":"Jia-Heng","family":"Shie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Tzu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2011.09.049_bib1","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.cellsig.2008.06.004","article-title":"Cell signaling in interstitial cystitis\/painful bladder syndrome","volume":"20","author":"Keay","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.urology.2011.09.049_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1442-2042.2009.02326.x","article-title":"Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome","volume":"16","author":"Homma","year":"2009","journal-title":"Int J Urol"},{"key":"10.1016\/j.urology.2011.09.049_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00345-007-0174-7","article-title":"Increased number of apoptotic endothelial cells in bladder of interstitial cystitis patients","volume":"25","author":"Yamada","year":"2007","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2011.09.049_bib4","doi-asserted-by":"crossref","first-page":"E136","DOI":"10.1111\/j.1464-410X.2010.09911.x","article-title":"Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis\/painful bladder syndrome","volume":"108","author":"Shie","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2011.09.049_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1155\/MI.2005.273","article-title":"Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity","volume":"2005","author":"Arican","year":"2005","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.urology.2011.09.049_bib6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1023\/A:1020546615229","article-title":"TNF-induced signaling in apoptosis","volume":"19","author":"Rath","year":"1999","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.urology.2011.09.049_bib7","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0006-2952(03)00490-8","article-title":"Regulation of proliferation, survival and apoptosis by members of the TNF superfamily","volume":"66","author":"Gaur","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.urology.2011.09.049_bib8","doi-asserted-by":"crossref","first-page":"18518","DOI":"10.1074\/jbc.272.30.18518","article-title":"Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells","volume":"272","author":"Kawasaki","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.urology.2011.09.049_bib9","doi-asserted-by":"crossref","first-page":"F1556","DOI":"10.1152\/ajprenal.00010.2007","article-title":"MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney","volume":"293","author":"Ma","year":"2007","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.urology.2011.09.049_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.abb.2005.10.009","article-title":"p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation","volume":"444","author":"Kim","year":"2005","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.urology.2011.09.049_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1084\/jem.20041502","article-title":"Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope","volume":"201","author":"Perfettini","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.urology.2011.09.049_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(99)00071-6","article-title":"The p38 signal transduction pathway: activation and function","volume":"12","author":"Ono","year":"2000","journal-title":"Cell Signal"},{"key":"10.1016\/j.urology.2011.09.049_bib13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1464-410X.2008.08097.x","article-title":"Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation","volume":"103","author":"Kim","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2011.09.049_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"van de Merwe","year":"2008","journal-title":"Eur Urol"},{"issue":"suppl 1","key":"10.1016\/j.urology.2011.09.049_bib15","first-page":"155","article-title":"Techniques of image analysis for quantitative immunohistochemistry","volume":"49","author":"Kaczmarek","year":"2004","journal-title":"Rocz Akad Med Bialymst"},{"key":"10.1016\/j.urology.2011.09.049_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ccr.2006.12.013","article-title":"p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis","volume":"11","author":"Dolado","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.urology.2011.09.049_bib17","doi-asserted-by":"crossref","first-page":"25215","DOI":"10.1074\/jbc.M512627200","article-title":"p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65","volume":"281","author":"Cai","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.urology.2011.09.049_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0248-4900(01)01124-8","article-title":"Cell cycle regulation by p38 MAP kinases","volume":"93","author":"Ambrosino","year":"2001","journal-title":"Biol Cell"},{"key":"10.1016\/j.urology.2011.09.049_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/cr.2007.19","article-title":"p53 and Bad: remote strangers become close friends","volume":"17","author":"Jiang","year":"2007","journal-title":"Cell Res"},{"key":"10.1016\/j.urology.2011.09.049_bib20","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.molimm.2006.10.009","article-title":"Differential regulation of TNFalpha and GM-CSF induced activation of p38 MAPK in neutrophils and eosinophils","volume":"44","author":"ten Hove","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.urology.2011.09.049_bib21","first-page":"267","article-title":"Role of p38 MAPK in the regulation of apoptosis signaling induced by TNF-alpha in differentiated PC12 cells","volume":"35","author":"Park","year":"2002","journal-title":"J Biochem Mol Biol"},{"key":"10.1016\/j.urology.2011.09.049_bib22","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.2174\/092986709788803024","article-title":"TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma","volume":"16","author":"Esposito","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.urology.2011.09.049_bib23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H","article-title":"TNF alpha and the TNF receptor superfamily: structure-function relationship(s)","volume":"50","author":"Idriss","year":"2000","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.urology.2011.09.049_bib24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11255-009-9632-z","article-title":"Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis","volume":"42","author":"Kutlu","year":"2010","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.urology.2011.09.049_bib25","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1097\/00001756-199705060-00012","article-title":"NGF involvement in pain induced by chronic constriction injury of the rat sciatic nerve","volume":"8","author":"Herzberg","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.urology.2011.09.049_bib26","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1523\/JNEUROSCI.22-02-00536.2002","article-title":"Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve","volume":"22","author":"Sch\u00e4fers","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.urology.2011.09.049_bib27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(01)02743-3","article-title":"Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy","volume":"913","author":"Sommer","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.urology.2011.09.049_bib28","doi-asserted-by":"crossref","first-page":"F741","DOI":"10.1152\/ajprenal.00081.2006","article-title":"Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis","volume":"291","author":"Chen","year":"2006","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.urology.2011.09.049_bib29","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1021\/jm0611004","article-title":"Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)","volume":"50","author":"Anderson","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.urology.2011.09.049_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.bjp.0703605","article-title":"Effect of the p38 kinase inhibitor, SB203580, on allergic airway inflammation in the rat","volume":"131","author":"Escott","year":"2000","journal-title":"Br J Pharmacol"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429511025817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429511025817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:56:30Z","timestamp":1758765390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429511025817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0090429511025817"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2011.09.049","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Cell Apoptosis of Urothelium Mediated by Inflammation in Interstitial Cystitis\/Painful Bladder Syndrome","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2011.09.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}