{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:05:45Z","timestamp":1769832345051,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99-2314-B-002-067-MY3"],"award-info":[{"award-number":["NSC 99-2314-B-002-067-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.urology.2011.11.027","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T14:17:31Z","timestamp":1327933051000},"page":"967.e5-967.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Honokiol Attenuates Torsion\/Detorsion-induced Testicular Injury in Rat Testis by Way of Suppressing Endoplasmic Reticulum Stress-related Apoptosis"],"prefix":"10.1016","volume":"79","author":[{"given":"Kuo-How","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te-I.","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyh-Chyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing-Hwa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2011.11.027_bib1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0022-5347(17)38875-4","article-title":"Testicular salvage and age-related delay in the presentation of testicular torsion","volume":"142","author":"Barada","year":"1989","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2011.11.027_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0022-5347(17)52758-5","article-title":"High testicular salvage rate in torsion of the spermatic cord","volume":"128","author":"Cattolica","year":"1982","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2011.11.027_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1464-410X.1978.tb02764.x","article-title":"The testes after torsion","volume":"50","author":"Krarup","year":"1978","journal-title":"Br J Urol"},{"key":"10.1016\/j.urology.2011.11.027_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/bjs.1800611112","article-title":"Torsion of the testis in childhood","volume":"61","author":"Macnicol","year":"1974","journal-title":"Br J Surg"},{"key":"10.1016\/j.urology.2011.11.027_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0022-5347(17)61267-9","article-title":"Anatomy and diagnosis of torsion of the testicle","volume":"106","author":"Parker","year":"1971","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2011.11.027_bib6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0022-5347(01)65374-6","article-title":"Rescue of testicular function after acute experimental torsion","volume":"157","author":"Prillaman","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2011.11.027_bib7","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1095\/biolreprod57.6.1267","article-title":"Acute testicular ischemia results in germ cell-specific apoptosis in the rat","volume":"57","author":"Turner","year":"1997","journal-title":"Biol Reprod"},{"key":"10.1016\/j.urology.2011.11.027_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mam.2004.02.020","article-title":"Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury","volume":"25","author":"Filho","year":"2004","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.urology.2011.11.027_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jss.2005.11.572","article-title":"The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion","volume":"131","author":"Cay","year":"2006","journal-title":"J Surg Res"},{"key":"10.1016\/j.urology.2011.11.027_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.urology.2008.01.064","article-title":"Taurine reduces testicular ischemia\/reperfusion-induced neutrophil recruitment to testis probably by downregulation of pro-inflammatory cytokines and E-selectin","volume":"72","author":"Wei","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.urology.2011.11.027_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.fertnstert.2007.10.082","article-title":"Curcumin attenuates ischemia-reperfusion injury in rat testis","volume":"91","author":"Wei","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.urology.2011.11.027_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/sj.cdd.4401817","article-title":"Cellular response to endoplasmic reticulum stress: a matter of life or death","volume":"13","author":"Boyce","year":"2006","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.urology.2011.11.027_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.jcbfm.9600005","article-title":"Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons","volume":"25","author":"Hayashi","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.urology.2011.11.027_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2010.10.017","article-title":"Ischemic postconditioning protects brain from ischemia\/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway","volume":"1367","author":"Yuan","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.urology.2011.11.027_bib15","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1038\/cddis.2010.29","article-title":"Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion","volume":"1","author":"Ben Mosbah","year":"2010","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.urology.2011.11.027_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1053\/j.gastro.2010.10.040","article-title":"Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia\/reperfusion","volume":"140","author":"Grootjans","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.urology.2011.11.027_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12640-009-9110-5","article-title":"Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia\/reperfusion in rats","volume":"17","author":"Nakka","year":"2010","journal-title":"Neurotox Res"},{"key":"10.1016\/j.urology.2011.11.027_bib18","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1096\/fj.06-6054com","article-title":"Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells","volume":"21","author":"Yung","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.urology.2011.11.027_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1055\/s-2003-37707","article-title":"Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats","volume":"69","author":"Liou","year":"2003","journal-title":"Planta Med"},{"key":"10.1016\/j.urology.2011.11.027_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2003.08.026","article-title":"Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production","volume":"992","author":"Liou","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.urology.2011.11.027_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(03)02121-6","article-title":"The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production","volume":"475","author":"Liou","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.urology.2011.11.027_bib22","doi-asserted-by":"crossref","first-page":"e1096","DOI":"10.1371\/journal.pone.0001096","article-title":"Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth","volume":"2","author":"Sheu","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.urology.2011.11.027_bib23","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.bcp.2005.08.011","article-title":"Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation","volume":"70","author":"Tse","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.urology.2011.11.027_bib24","first-page":"2","article-title":"Testicular biopsy score count\u2014a method for registration of spermatogenesis in human testes: Normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"10.1016\/j.urology.2011.11.027_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12035-007-8013-9","article-title":"Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities","volume":"37","author":"Nakka","year":"2008","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.urology.2011.11.027_bib26","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1046\/j.1471-4159.2001.00387.x","article-title":"Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK","volume":"77","author":"Kumar","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.urology.2011.11.027_bib27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbadis.2005.04.007","article-title":"Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK","volume":"1741","author":"Montie","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.urology.2011.11.027_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2004.02703.x","article-title":"Cerebral ischemia and the unfolded protein response","volume":"91","author":"DeGracia","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.urology.2011.11.027_bib29","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"PERK is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol Cell"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429511026628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429511026628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:55:05Z","timestamp":1758765305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429511026628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0090429511026628"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2011.11.027","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Honokiol Attenuates Torsion\/Detorsion-induced Testicular Injury in Rat Testis by Way of Suppressing Endoplasmic Reticulum Stress-related Apoptosis","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2011.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}