{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:34:07Z","timestamp":1793036047980,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.urology.2012.05.030","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:45:58Z","timestamp":1346114758000},"page":"953.e1-953.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Activation of VEGF and ERK1\/2 and Improvement of Urethral Function by Adipose-derived Stem Cells in a Rat Stress Urinary Incontinence Model"],"prefix":"10.1016","volume":"80","author":[{"given":"Guang-Yong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Shou","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ren","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Zhu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Lu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Cheng","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2012.05.030_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1532-5415.1998.tb02469.x","article-title":"Variation in estimates of urinary incontinence prevalence in the community: effects of differences in definition, population characteristics, and study type","volume":"46","author":"Thom","year":"1998","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.urology.2012.05.030_bib2","first-page":"66","article-title":"Prevalence of urinary incontinence and associated risk factors in postmenopausal women","volume":"94","author":"Brown","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.urology.2012.05.030_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.acthis.2006.07.001","article-title":"Changes in the extracellular matrix in periurethral tissue of women with stress urinary incontinence","volume":"108","author":"Goepel","year":"2006","journal-title":"Acta Histochem"},{"key":"10.1016\/j.urology.2012.05.030_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11010-012-1234-x","article-title":"Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-\u03b21\/Smad pathway","volume":"364","author":"Li","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.urology.2012.05.030_bib5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/nau.20357","article-title":"Presentation and management of major complications of midurethral slings: are complications under-reported?","volume":"26","author":"Deng","year":"2007","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.urology.2012.05.030_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejogrb.2009.04.020","article-title":"Surgical management of urinary stress incontinence in women: a historical and clinical overview","volume":"145","author":"Hinoul","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.urology.2012.05.030_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.eururo.2007.07.026","article-title":"Adult stem cell therapy of female stress urinary incontinence","volume":"53","author":"Mitterberger","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2012.05.030_bib8","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.juro.2009.11.012","article-title":"Adipose derived stem cells ameliorate hyperlipidemia associated detrusor overactivity in a rat model","volume":"183","author":"Huang","year":"2010","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2012.05.030_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/157488810791268564","article-title":"Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine","volume":"5","author":"Salgado","year":"2010","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.urology.2012.05.030_bib10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cytogfr.2009.10.014","article-title":"Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both?","volume":"20","author":"Chen","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.urology.2012.05.030_bib11","doi-asserted-by":"crossref","first-page":"H415","DOI":"10.1152\/ajpheart.00391.2009","article-title":"Adipose tissue-derived stem cells inhibit neointimal formation in a paracrine fashion in rat femoral artery","volume":"298","author":"Takahashi","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.urology.2012.05.030_bib12","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1111\/j.1743-6109.2010.01875.x","article-title":"Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury","volume":"7","author":"Albersen","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2012.05.030_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/14653240903350265","article-title":"Treatment of stress urinary incontinence with adipose tissue-derived stem cells","volume":"12","author":"Lin","year":"2010","journal-title":"Cytotherapy"},{"key":"10.1016\/j.urology.2012.05.030_bib14","first-page":"233","article-title":"From growth to cell cycle control","volume":"2","author":"Ducommun","year":"1991","journal-title":"Semin Cell Biol"},{"key":"10.1016\/j.urology.2012.05.030_bib15","first-page":"524","article-title":"[Effect of extracellular signal-regulated kinase antisense oligodeoxynucleotides on the proliferation of passively sensitized human airway smooth muscle cells]","volume":"33","author":"Bai","year":"2010","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"10.1016\/j.urology.2012.05.030_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jep.2011.02.011","article-title":"The effects of BuYang HuanWu decoction and its effective components on proliferation-related factors and ERK1\/2 signal transduction pathway in cultured vascular smooth muscle cells","volume":"135","author":"Chen","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.urology.2012.05.030_bib17","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1097\/01.WCB.0000090620.86921.9C","article-title":"Activation of receptor-mediated angiogenesis and signaling pathways after VEGF administration in fetal rat CNS explants","volume":"23","author":"Mani","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.urology.2012.05.030_bib18","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1517\/14712598.2010.522987","article-title":"The pivotal role of VEGF in adipose-derived-stem-cell-mediated regeneration","volume":"10","author":"Song","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.urology.2012.05.030_bib19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/j.1464-410X.2010.09268.x","article-title":"The effect of long-term hormonal treatment on voiding patterns during filling cystometry and on urethral histology in a postpartum, ovariectomized female rat","volume":"106","author":"Breyer","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2012.05.030_bib20","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.urology.2011.07.1381","article-title":"Effects of prolonged vaginal distension and \u03b2-aminopropionitrile on urinary continence and urethral structure","volume":"78","author":"Wang","year":"2011","journal-title":"Urology"},{"key":"10.1016\/j.urology.2012.05.030_bib21","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1089\/scd.2008.0117","article-title":"Defining stem and progenitor cells within adipose tissue","volume":"17","author":"Lin","year":"2008","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.urology.2012.05.030_bib22","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3109\/14653240903180084","article-title":"Labeling and tracking of mesenchymal stromal cells with EdU","volume":"11","author":"Lin","year":"2009","journal-title":"Cytotherapy"},{"key":"10.1016\/j.urology.2012.05.030_bib23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.urology.2009.10.003","article-title":"Myoblasts differentiated from adipose-derived stem cells to treat stress urinary incontinence","volume":"75","author":"Fu","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.urology.2012.05.030_bib24","first-page":"256","article-title":"Effect of extended-term estrogen on voiding in a postpartum ovariectomized rat model","volume":"1","author":"Hayashi","year":"2007","journal-title":"Can Urol Assoc J"},{"key":"10.1016\/j.urology.2012.05.030_bib25","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1016\/j.urology.2010.02.055","article-title":"Effects of birth trauma and estrogen on urethral elastic fibers and elastin expression","volume":"76","author":"Lin","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.urology.2012.05.030_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1078\/0065-1281-00646","article-title":"Reticulin fibres in the tunica albuginea and peritubular tissue of seminiferous tubules of adult male Wistar rats","volume":"104","author":"Fakoya","year":"2002","journal-title":"Acta Histochem"},{"key":"10.1016\/j.urology.2012.05.030_bib27","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.urology.2005.06.113","article-title":"Estrogen and ghrelin increase number of submucosal urethral and anal canal blood vessels in ovariectomized rats","volume":"66","author":"Rizk","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.urology.2012.05.030_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.eururo.2010.10.038","article-title":"Periurethral injection of autologous adipose-derived stem cells with controlled-release nerve growth factor for the treatment of stress urinary incontinence in a rat model","volume":"59","author":"Zhao","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2012.05.030_bib29","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajog.2003.08.040","article-title":"Impact of menopause on collagen subtypes in the arcus tendineous fasciae pelvis","volume":"190","author":"Moalli","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.urology.2012.05.030_bib30","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/nau.20998","article-title":"Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence","volume":"30","author":"Corcos","year":"2011","journal-title":"Neurourol Urodyn"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429512006231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429512006231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:56:44Z","timestamp":1758765404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429512006231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0090429512006231"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2012.05.030","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of VEGF and ERK1\/2 and Improvement of Urethral Function by Adipose-derived Stem Cells in a Rat Stress Urinary Incontinence Model","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2012.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}