{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T12:23:34Z","timestamp":1707999814462},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.urology.2012.09.010","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T10:37:08Z","timestamp":1356604628000},"page":"178-183","source":"Crossref","is-referenced-by-count":4,"title":["c-Jun N-Terminal Kinase is Upregulated in Patients With Hypospadias"],"prefix":"10.1016","volume":"81","author":[{"given":"Mingyong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2012.09.010_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1289\/ehp.99107297","article-title":"International trends in rates of hypospadias and cryptorchidism","volume":"107","author":"Paulozzi","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.urology.2012.09.010_bib2","first-page":"499","article-title":"Endocrine disruptors, genital development, and hypospadias","volume":"29","author":"Wang","year":"2008","journal-title":"J\u00a0Androl"},{"key":"10.1016\/j.urology.2012.09.010_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4419-8995-6_1","article-title":"Hypospadias","volume":"545","author":"Baskin","year":"2004","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.urology.2012.09.010_bib4","first-page":"1894","article-title":"Molecular effects of genistein on male urethral development","volume":"185","author":"Ross","year":"2011","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2012.09.010_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s001090050063","article-title":"Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways","volume":"74","author":"Whitmarsh","year":"1996","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.urology.2012.09.010_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.urology.2012.09.010_bib7","doi-asserted-by":"crossref","first-page":"19992","DOI":"10.1074\/jbc.M500331200","article-title":"JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53","volume":"280","author":"Tafolla","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.urology.2012.09.010_bib8","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/j.1460-2075.1996.tb00636.x","article-title":"Selective interaction of JNK protein kinase isoforms with transcription factors","volume":"15","author":"Gupta","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.urology.2012.09.010_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s004410000345","article-title":"Urethral seam formation and hypospadias","volume":"305","author":"Baskin","year":"2001","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.urology.2012.09.010_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature01745","article-title":"JNK phosphorylates paxillin and regulates cell migration","volume":"424","author":"Huang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.urology.2012.09.010_bib11","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1203\/01.pdr.0000187796.28007.2d","article-title":"Activating transcription factor 3 is up-regulated in patients with hypospadias","volume":"58","author":"Liu","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.urology.2012.09.010_bib12","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1101\/gad.10.21.2759","article-title":"The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye","volume":"10","author":"Riesgo-Escovar","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/j.urology.2012.09.010_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1432-0436.2002.700408.x","article-title":"Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila","volume":"70","author":"Harden","year":"2002","journal-title":"Differentiation"},{"key":"10.1016\/j.urology.2012.09.010_bib14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ncpuro0783","article-title":"Candidate genes and their response to environmental agents in the etiology of hypospadias","volume":"4","author":"Willingham","year":"2007","journal-title":"Nat Clin Pract Urol"},{"key":"10.1016\/j.urology.2012.09.010_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/jmedgenet-2011-100174","article-title":"A\u00a0genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation","volume":"49","author":"Dalgaard","year":"2012","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.urology.2012.09.010_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/15287390802114915","article-title":"Di(2-ethylhexyl) phthalate (DEHP) increases transforming growth factor-beta1 expression in fetal mouse genital tubercles","volume":"71","author":"Liu","year":"2008","journal-title":"J\u00a0Toxicol Environ Health A"},{"key":"10.1016\/j.urology.2012.09.010_bib17","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1073\/pnas.97.10.5243","article-title":"MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration","volume":"97","author":"Xia","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.urology.2012.09.010_bib18","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1073\/pnas.130176697","article-title":"MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation","volume":"97","author":"Yujiri","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.urology.2012.09.010_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1055\/s-2004-821275","article-title":"Genetic and molecular aspects of hypospadias","volume":"14","author":"Utsch","year":"2004","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.urology.2012.09.010_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1432-0436.1999.6420115.x","article-title":"Ontogeny of the male urethra: theory of endodermal differentiation","volume":"64","author":"Kurzrock","year":"1999","journal-title":"Differentiation"},{"key":"10.1016\/j.urology.2012.09.010_bib21","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1100\/tsw.2010.112","article-title":"Penile embryology and anatomy","volume":"10","author":"Yiee","year":"2010","journal-title":"Sci World J"},{"key":"10.1016\/j.urology.2012.09.010_bib22","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1093\/emboj\/cdf446","article-title":"Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling","volume":"21","author":"Abassi","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.urology.2012.09.010_bib23","first-page":"7079","article-title":"Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells","volume":"61","author":"Hauck","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.urology.2012.09.010_bib24","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1242\/jcs.115.15.3073","article-title":"Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis","volume":"115","author":"Huynh-Do","year":"2002","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.urology.2012.09.010_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2011.01.006","article-title":"Hypospadias: interactions between environment and genetics","volume":"335","author":"Kalfa","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.urology.2012.09.010_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1210\/me.2005-0351","article-title":"Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization","volume":"20","author":"Gioeli","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.urology.2012.09.010_bib27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1593\/neo.07985","article-title":"Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation","volume":"10","author":"Lorenzo","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.urology.2012.09.010_bib28","first-page":"1231","article-title":"Genistein differentially modulates androgen-responsive gene expression and activates JNK in LNCaP cells","volume":"19","author":"Lazarevic","year":"2008","journal-title":"Oncol Rep"},{"key":"10.1016\/j.urology.2012.09.010_bib29","first-page":"1883","article-title":"Ontogeny of androgen receptor and disruption of its mRNA expression by exogenous estrogens during morphogenesis of the genital tubercle","volume":"176","author":"Agras","year":"2006","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2012.09.010_bib30","first-page":"1888","article-title":"ZEB1 is estrogen responsive in\u00a0vitro in human foreskin cells and is over expressed in penile skin in patients with severe hypospadias","volume":"185","author":"Qiao","year":"2011","journal-title":"J\u00a0Urol"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429512010801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429512010801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T18:22:22Z","timestamp":1643998942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429512010801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0090429512010801"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2012.09.010","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}