{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:00Z","timestamp":1791216360762,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.urology.2013.01.028","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T15:02:04Z","timestamp":1363186924000},"page":"1108.e1-1108.e6","source":"Crossref","is-referenced-by-count":14,"title":["Involvement of Connexins 43 and 45 in Functional Mechanism of Human Detrusor Overactivity in Neurogenic Bladder"],"prefix":"10.1016","volume":"81","author":[{"given":"V\u00e9ronique","family":"Ph\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Behr-Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Oger-Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Roupr\u00eat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Chartier-Kastler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lebret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Karsenty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Comp\u00e9rat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Camparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2013.01.028_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/nau.10052","article-title":"The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society","volume":"21","author":"Abrams","year":"2002","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.urology.2013.01.028_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0090-4295(97)00591-8","article-title":"A\u00a0myogenic basis for the overactive bladder","volume":"50","author":"Brading","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.urology.2013.01.028_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.eururo.2006.11.016","article-title":"Human idiopathic and neurogenic overactive bladders and the role of M2 muscarinic receptors in contraction","volume":"52","author":"Stevens","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2013.01.028_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.urology.2003.11.005","article-title":"Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity?","volume":"63","author":"Fry","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.urology.2013.01.028_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cardiores.2003.11.013","article-title":"Gap junctions and the connexin protein family","volume":"62","author":"S\u00f6hl","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.urology.2013.01.028_bib6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.eururo.2004.08.020","article-title":"Increased expression of connexin 43 in the overactive neurogenic detrusor","volume":"46","author":"Haferkamp","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2013.01.028_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00345-008-0365-x","article-title":"Connexin 45 expression in the human obstructed detrusor muscle","volume":"27","author":"John","year":"2009","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2013.01.028_bib8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1464-410X.2005.05703.x","article-title":"Alterations in connexin expression in the bladder of patients with urge symptoms","volume":"96","author":"Neuhaus","year":"2005","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.01.028_bib9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00345-002-0289-9","article-title":"Smooth muscle cells from human urinary bladder express connexin 43 in\u00a0vivo and in\u00a0vitro","volume":"20","author":"Neuhaus","year":"2002","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2013.01.028_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1464-410X.2003.04342.x","article-title":"Impedance measurements and connexin expression in human detrusor muscle from stable and unstable bladders","volume":"92","author":"Sui","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.01.028_bib11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1464-410X.2002.02834.x","article-title":"Gap junctions and connexin expression in human suburothelial interstitial cells","volume":"90","author":"Sui","year":"2002","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.01.028_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0090-4295(01)01042-1","article-title":"Gap junction channel activity in cultured human bladder smooth muscle cell pairs: gating and unitary conductances","volume":"57","author":"Wang","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.urology.2013.01.028_bib13","doi-asserted-by":"crossref","first-page":"F1018","DOI":"10.1152\/ajprenal.00183.2007","article-title":"Role of gap junctions in spontaneous activity of the rat bladder","volume":"293","author":"Ikeda","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.urology.2013.01.028_bib14","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.urology.2007.11.100","article-title":"Comprehensive evaluation of bladder and urethral dysfunction symptoms: development and psychometric validation of the Urinary Symptom Profile (USP) questionnaire","volume":"71","author":"Haab","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.urology.2013.01.028_bib15","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.2174\/138161210793292528","article-title":"Peptides targeting gap junctional structures","volume":"16","author":"Herv\u00e9","year":"2010","journal-title":"Curr Pharmaceut Design"},{"key":"10.1016\/j.urology.2013.01.028_bib16","doi-asserted-by":"crossref","first-page":"e2801","DOI":"10.1371\/journal.pone.0002801","article-title":"ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia","volume":"3","author":"Faigle","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.urology.2013.01.028_bib17","doi-asserted-by":"crossref","first-page":"C1627","DOI":"10.1152\/ajpcell.00122.2007","article-title":"Changes of gap junctional cell-cell communication in overactive detrusor in rats","volume":"293","author":"Li","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.urology.2013.01.028_bib18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1524-475X.2009.00471.x","article-title":"Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in\u00a0vitro","volume":"17","author":"Wright","year":"2009","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.urology.2013.01.028_bib19","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.eururo.2006.10.028","article-title":"Acetylcholine and molecular components of its synthesis and release machinery in the urothelium","volume":"51","author":"Lips","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2013.01.028_bib20","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/nau.20483","article-title":"The function of suburothelial myofibroblasts in the bladder","volume":"26","author":"Fry","year":"2007","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.urology.2013.01.028_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/nau.20739","article-title":"Interstitial cells in the urinary bladder\u2014localization and function","volume":"29","author":"McCloskey","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.urology.2013.01.028_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5213\/inj.2011.15.1.25","article-title":"Sex- and age-related changes in connexin 43 expression in normal rat bladder","volume":"15","author":"Song","year":"2011","journal-title":"Int Neurourol J"},{"key":"10.1016\/j.urology.2013.01.028_bib23","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1111\/j.1464-410X.2008.08337.x","article-title":"Effects of ageing and streptozotocin-induced diabetes on connexin 43 and P2 purinoceptor expression in the rat corpora cavernosa and urinary bladder","volume":"103","author":"Suadicani","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.01.028_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/15419060801891034","article-title":"Mimetic peptides as blockers of connexin channel-facilitated intercellular communication","volume":"14","author":"Evans","year":"2007","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.urology.2013.01.028_bib25","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.bcp.2008.08.022","article-title":"The vascular effects of\u00a0rotigaptide in\u00a0vivo in man","volume":"76","author":"Lang","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.urology.2013.01.028_bib26","doi-asserted-by":"crossref","first-page":"H41","DOI":"10.1152\/ajpheart.01089.2006","article-title":"Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans","volume":"294","author":"Kjolbye","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.urology.2013.01.028_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1742-7843.2007.00123.x","article-title":"Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias","volume":"101","author":"Kjolbye","year":"2007","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.urology.2013.01.028_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/15419060802014164","article-title":"Connexin 43\u00a0mimetic peptides reduce swelling, astrogliosis, and neuronal cell\u00a0death after spinal cord injury","volume":"15","author":"O'Carroll","year":"2008","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.urology.2013.01.028_bib29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00232-012-9460-4","article-title":"Regulation of connexin 43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds","volume":"245","author":"Ormonde","year":"2012","journal-title":"J\u00a0Membr Biol"},{"key":"10.1016\/j.urology.2013.01.028_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2217\/17460751.4.2.205","article-title":"Connexin 43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding","volume":"4","author":"Ghatnekar","year":"2009","journal-title":"Regen Med"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513000897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513000897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T21:11:34Z","timestamp":1595538694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429513000897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0090429513000897"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2013.01.028","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}