{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:58:29Z","timestamp":1762459109135},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.urology.2013.07.012","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T09:31:08Z","timestamp":1377682268000},"page":"1197-1203","source":"Crossref","is-referenced-by-count":31,"title":["Opposing Roles of Folate in Prostate Cancer"],"prefix":"10.1016","volume":"82","author":[{"given":"Kevin J.","family":"Rycyna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean J.","family":"Bacich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise S.","family":"O'Keefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2013.07.012_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.urology.2013.07.012_bib2","first-page":"1792","article-title":"Evidence supports a faster growth rate and\/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity","volume":"183","author":"Powell","year":"2010","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2013.07.012_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/mnfr.200700511","article-title":"International epidemiology of prostate cancer: geographical distribution and secular trends","volume":"53","author":"Baade","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.urology.2013.07.012_bib4","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/pros.20419","article-title":"Rising prostate cancer rates in South Korea","volume":"66","author":"Park","year":"2006","journal-title":"Prostate"},{"key":"10.1016\/j.urology.2013.07.012_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/bjc.1991.210","article-title":"Cancers of the prostate and breast among Japanese and White immigrants in Los Angeles county","volume":"63","author":"Shimizu","year":"1991","journal-title":"Br J Cancer"},{"key":"10.1016\/j.urology.2013.07.012_bib6","unstructured":"National Cancer Institute. PDQ Prostate Cancer Prevention. Last modified March 29, 2012. Available at: http:\/\/www.cancer.gov\/cancertopics\/pdq\/prevention\/prostate\/healthprofessional. Accessed September, 24\u00a02012."},{"key":"10.1016\/j.urology.2013.07.012_bib7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jnci\/djp019","article-title":"Folic acid and risk of prostate cancer: results from a randomized clinical trial","volume":"101","author":"Figueiredo","year":"2009","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.urology.2013.07.012_bib8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3945\/an.111.000596","article-title":"Trafficking of intracellular folates","volume":"2","author":"Stover","year":"2011","journal-title":"Adv Nutr"},{"key":"10.1016\/j.urology.2013.07.012_bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/ajcn\/85.2.465","article-title":"Bioavailability of food folates is 80% of that of folic acid","volume":"85","author":"Winkels","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.urology.2013.07.012_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/abio.1994.1257","article-title":"Analysis of uracil in DNA by gas chromatography-mass spectrometry","volume":"219","author":"Blount","year":"1994","journal-title":"Anal Biochem"},{"key":"10.1016\/j.urology.2013.07.012_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ajmg.1320160105","article-title":"On the nature of folic acid-sensitive fragile sites in human chromosome: an hypothesis","volume":"16","author":"Krumdiek","year":"1983","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.urology.2013.07.012_bib12","first-page":"129","article-title":"Folate and carcinogenesis: an integrated scheme","volume":"130","author":"Choi","year":"2000","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.urology.2013.07.012_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.172.3979.161","article-title":"Inhibition of growth of leukemia cells by enzymic folate depletion","volume":"172","author":"Bertino","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.urology.2013.07.012_bib14","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1093\/jnci\/84.22.1740","article-title":"Effects of folate deficiency and supplementation on methylnitrosourea-induced rat mammary tumors","volume":"84","author":"Baggott","year":"1992","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.urology.2013.07.012_bib15","first-page":"5434","article-title":"Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse","volume":"60","author":"Song","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.urology.2013.07.012_bib16","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1096\/fj.09-130708","article-title":"Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools","volume":"23","author":"Bistulfi","year":"2009","journal-title":"Faseb J"},{"year":"2012","series-title":"Campbell-Walsh Urology","author":"Wein","key":"10.1016\/j.urology.2013.07.012_bib17"},{"key":"10.1016\/j.urology.2013.07.012_bib18","unstructured":"Hyattsville, MD. Date last modified 09\/01\/2012. Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire (or Examination Protocol, or Laboratory Protocol). Accessed 07\/20\/2012."},{"key":"10.1016\/j.urology.2013.07.012_bib19","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/ajcn\/86.3.718","article-title":"Trends in blood folate and vitamin B-12 concentrations in the United States, 1988 2004","volume":"86","author":"Pfeiffer","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"No. RR-14","key":"10.1016\/j.urology.2013.07.012_bib20","first-page":"1","article-title":"Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects","volume":"41","year":"1992","journal-title":"MMWR"},{"key":"10.1016\/j.urology.2013.07.012_bib21","unstructured":"Intakes ARotSCotSEoDR, its Panel on Folate OBV, Choline et\u00a0al.: Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. The National Academies Press,\u00a01998."},{"key":"10.1016\/j.urology.2013.07.012_bib22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/ijc.20646","article-title":"Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study","volume":"113","author":"Hultdin","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.urology.2013.07.012_bib23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/jnci\/djk177","article-title":"Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study","volume":"99","author":"Lawson","year":"2007","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.urology.2013.07.012_bib24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0959-8049(96)00373-5","article-title":"Diet and prostate cancer: a case-control study","volume":"33","author":"Vlajinac","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.urology.2013.07.012_bib25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1158\/1055-9965.EPI-04-0787","article-title":"Dietary folate and risk of prostate cancer in Italy","volume":"14","author":"Pelucchi","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.urology.2013.07.012_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.annepidem.2005.03.010","article-title":"Folate levels and cancer morbidity and mortality: prospective cohort study from Busselton, Western Australia","volume":"16","author":"Rossi","year":"2006","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.urology.2013.07.012_bib27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/01635580902846593","article-title":"Folate intake and prostate cancer risk: a case-control study","volume":"61","author":"Shannon","year":"2009","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.urology.2013.07.012_bib28","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/ejcn.2010.124","article-title":"Serum levels of folate, lycopene, beta-carotene, retinol and vitamin E and prostate cancer risk","volume":"64","author":"Beilby","year":"2010","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.urology.2013.07.012_bib29","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1001\/jama.2009.1622","article-title":"Cancer incidence and mortality after treatment with folic acid and vitamin B12","volume":"302","author":"Ebbing","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.urology.2013.07.012_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1158\/1055-9965.EPI-07-0657","article-title":"Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European prospective investigation into cancer and nutrition study","volume":"17","author":"Johansson","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.urology.2013.07.012_bib31","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/aje\/kwq148","article-title":"Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial","volume":"172","author":"Kristal","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.urology.2013.07.012_bib32","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/aje\/kwj126","article-title":"Folate nutrition and prostate cancer incidence in a large cohort of US men","volume":"163","author":"Stevens","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.urology.2013.07.012_bib33","first-page":"1271","article-title":"Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine","volume":"12","author":"Weinstein","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.urology.2013.07.012_bib34","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1158\/1055-9965.EPI-10-0180","article-title":"Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis","volume":"19","author":"Collin","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.urology.2013.07.012_bib35","doi-asserted-by":"crossref","first-page":"e000653","DOI":"10.1136\/bmjopen-2011-000653","article-title":"Cancer risk with folic acid supplements: a systematic review and meta-analysis","volume":"2","author":"Wien","year":"2012","journal-title":"BMJ Open"},{"key":"10.1016\/j.urology.2013.07.012_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1741-7007-8-6","article-title":"Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells","volume":"8","author":"Bistulfi","year":"2010","journal-title":"BMC Biol"},{"key":"10.1016\/j.urology.2013.07.012_bib37","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1158\/1940-6207.CAPR-11-0140","article-title":"Dietary folate deficiency blocks prostate cancer progression in the TRAMP model","volume":"4","author":"Bistulfi","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.urology.2013.07.012_bib38","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1464-410X.2011.10437.x","article-title":"Elevated physiological levels of folic acid can increase in\u00a0vitro growth and invasiveness of prostate cancer cells","volume":"109","author":"Petersen","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.07.012_bib39","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/pros.21346","article-title":"Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate","volume":"71","author":"Tomaszewski","year":"2011","journal-title":"Prostate"},{"key":"10.1016\/j.urology.2013.07.012_bib40","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/ajg.2010.189","article-title":"Revisiting the goldilocks phenomenon: folate and colorectal cancer risk","volume":"105","author":"Mason","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.urology.2013.07.012_bib41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/1752-1947-5-413","article-title":"Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report","volume":"5","author":"Tisman","year":"2011","journal-title":"J\u00a0Med Case Rep"},{"key":"10.1016\/j.urology.2013.07.012_bib42","first-page":"1445","article-title":"Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells","volume":"2","author":"Pinto","year":"1996","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.urology.2013.07.012_bib43","first-page":"81","article-title":"Prostate-specific membrane antigen expression in normal and malignant human tissues","volume":"3","author":"Silver","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.urology.2013.07.012_bib44","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2256::AID-CNCR22>3.0.CO;2-S","article-title":"Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adneocarcinoma: a study of 184 cases","volume":"82","author":"Bostwick","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.urology.2013.07.012_bib45","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/1097-0045(20001201)45:4<350::AID-PROS10>3.0.CO;2-U","article-title":"Prostate-specific membrane antigen (PSMA) enzyme activity is elevated in prostate cancer cells","volume":"45","author":"Lapidus","year":"2000","journal-title":"Prostate"},{"key":"10.1016\/j.urology.2013.07.012_bib46","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1128\/MCB.00084-06","article-title":"Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction","volume":"26","author":"Conway","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.urology.2013.07.012_bib47","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1158\/0008-5472.CAN-08-2328","article-title":"Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis","volume":"68","author":"Yao","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.urology.2013.07.012_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/pros.21065","article-title":"Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid","volume":"70","author":"Yao","year":"2010","journal-title":"Prostate"},{"key":"10.1016\/j.urology.2013.07.012_bib49","first-page":"6357","article-title":"Correlation of primary tumor prostate-specific membrane antigen expression with disease recurrence in prostate cancer","volume":"9","author":"Ross","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.urology.2013.07.012_bib50","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0090-4295(96)00184-7","article-title":"Upregulation of prostate-specific membrane antigen after androgen deprivation therapy","volume":"48","author":"Wright","year":"1996","journal-title":"Urology"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513008510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513008510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T19:58:02Z","timestamp":1646423882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429513008510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0090429513008510"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2013.07.012","relation":{},"ISSN":["0090-4295"],"issn-type":[{"type":"print","value":"0090-4295"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}