{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T09:39:12Z","timestamp":1793612352597,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.urology.2013.09.069","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T06:21:23Z","timestamp":1393395683000},"page":"675.e1-675.e6","source":"Crossref","is-referenced-by-count":12,"title":["Higher Prevalence of Novel Mutations in VHL Gene in Chinese Von Hippel-Lindau Disease Patients"],"prefix":"10.1016","volume":"83","author":[{"given":"Xi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghe","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingfang","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2013.09.069_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9343(64)90107-X","article-title":"Lindau's disease. Review of the literature and study of a large kindred","volume":"36","author":"Melmon","year":"1964","journal-title":"Am J Med"},{"key":"10.1016\/j.urology.2013.09.069_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/jmg.28.7.443","article-title":"Von Hippel-Lindau disease: a genetic study","volume":"28","author":"Maher","year":"1991","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.urology.2013.09.069_bib3","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0140-6736(91)91705-Y","article-title":"Clustering of features and genetics of von Hippel-Lindau syndrome","volume":"337","author":"Neumann","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.urology.2013.09.069_bib4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/jmg.33.2.120","article-title":"A\u00a0genetic register for von Hippel-Lindau disease","volume":"33","author":"Maddock","year":"1996","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.urology.2013.09.069_bib5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.urology.2013.09.069_bib6","first-page":"1151","article-title":"Clinical features and natural history of von Hippel-Lindau disease","volume":"77","author":"Maher","year":"1990","journal-title":"Q\u00a0J Med"},{"key":"10.1016\/j.urology.2013.09.069_bib7","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/jnnp.55.10.898","article-title":"Central nervous system lesions in von Hippel-Lindau syndrome","volume":"55","author":"Neumann","year":"1992","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.urology.2013.09.069_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/jhg.2012.10","article-title":"Family history of von Hippel-Lindau disease was uncommon in Chinese patients: suggesting the higher frequency of de novo mutations in VHL gene in these patients","volume":"57","author":"Wu","year":"2012","journal-title":"J\u00a0Hum Genet"},{"key":"10.1016\/j.urology.2013.09.069_bib9","first-page":"47","article-title":"Germline mutations of the VHL gene in seven Chinese families with von Hippel-Lindau disease","volume":"29","author":"Huang","year":"2012","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.urology.2013.09.069_bib10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00432-008-0399-x","article-title":"Germline mutations in the von Hippel-Lindau disease (VHL) gene in mainland Chinese families","volume":"134","author":"Zhang","year":"2008","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"10.1016\/j.urology.2013.09.069_bib11","first-page":"539","article-title":"[Large germline deletion of the VHL gene in Chinese families with von Hippel-Lindau syndrome]","volume":"26","author":"Zhang","year":"2009","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"10.1016\/j.urology.2013.09.069_bib12","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1179\/174313209X382421","article-title":"Familial and genetic researches on three Chinese families with von Hippel-Lindau disease","volume":"31","author":"Mao","year":"2009","journal-title":"Neurol Res"},{"key":"10.1016\/j.urology.2013.09.069_bib13","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1440-1827.2010.02540.x","article-title":"Molecularly genetic analysis of von Hippel-Lindau associated central nervous system hemangioblastoma","volume":"60","author":"Zhou","year":"2010","journal-title":"Pathol Int"},{"key":"10.1016\/j.urology.2013.09.069_bib14","first-page":"237","article-title":"Molecular basis of von Hippel-Lindau syndrome in Chinese patients","volume":"124","author":"Siu","year":"2011","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"10.1016\/j.urology.2013.09.069_bib15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12094-012-0940-x","article-title":"Clinical and mutation analysis of four Chinese families with von Hippel-Lindau disease","volume":"15","author":"Chen","year":"2013","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.urology.2013.09.069_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11060-012-1015-0","article-title":"A\u00a0c.464T>a mutation in VHL gene in a Chinese family with VHL syndrome","volume":"111","author":"Lu","year":"2013","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.urology.2013.09.069_bib17","first-page":"125","article-title":"[Papillary cystadenoma of epididymis in von Hippel-Lindau syndrome: report of a case]","volume":"41","author":"Pan","year":"2012","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"10.1016\/j.urology.2013.09.069_bib18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1001-9294(10)60001-6","article-title":"Bilateral pheochromocytoma as first presentation of von Hippel-Lindau disease in a Chinese family","volume":"24","author":"Tong","year":"2009","journal-title":"Chin Med Sci J"},{"key":"10.1016\/j.urology.2013.09.069_bib19","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1136\/jmg.40.3.e31","article-title":"High frequency of novel germline mutations in the VHL gene in the heterogeneous population of Brazil","volume":"40","author":"Rocha","year":"2003","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.urology.2013.09.069_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/cge.12092","article-title":"Mosaicism in von Hippel-Lindau disease with severe renal manifestations","author":"Wu","year":"2013","journal-title":"Clin Genet"},{"key":"10.1016\/j.urology.2013.09.069_bib21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3","article-title":"Germline mutations in the von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan","volume":"8","author":"Zbar","year":"1996","journal-title":"Hum Mutat"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513014969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513014969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T10:24:10Z","timestamp":1538821450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429513014969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0090429513014969"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2013.09.069","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}