{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:08:31Z","timestamp":1792818511233,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.urology.2013.11.032","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T06:20:07Z","timestamp":1393395607000},"page":"675.e13-675.e18","source":"Crossref","is-referenced-by-count":18,"title":["Rho-kinase Levels in Testicular Ischemia-reperfusion Injury and Effects of Its Inhibitor, Y-27632, on Oxidative Stress, Spermatogenesis, and Apoptosis"],"prefix":"10.1016","volume":"83","author":[{"given":"Selahittin","family":"\u00c7ayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"Saylam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalan","family":"Tiftik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nil Do\u011fruer","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu D\u00fc\u015fmez","family":"Apa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Efesoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"\u00c7imen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bozlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Akbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kansu","family":"B\u00fcy\u00fckaf\u015far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2013.11.032_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1464-410X.2003.04307.x","article-title":"Testicular function after torsion of the spermatic cord","volume":"92","author":"Visser","year":"2003","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.11.032_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0031-6997(24)01484-4","article-title":"Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia\/reperfusion injury","volume":"53","author":"Cuzzocrea","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.urology.2013.11.032_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0002-9610(91)91120-8","article-title":"Pharmacologic approach to tissue injury mediated by free radicals other reactive oxygen metabolites","volume":"161","author":"Reilly","year":"1991","journal-title":"Am J Surg"},{"key":"10.1016\/j.urology.2013.11.032_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1439-0272.2005.00699.x","article-title":"The impact of oxidants on sperm function","volume":"37","author":"Henkel","year":"2005","journal-title":"Andrologia"},{"key":"10.1016\/j.urology.2013.11.032_bib5","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00000542-200106000-00030","article-title":"Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury","volume":"94","author":"Collard","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.urology.2013.11.032_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-5793(99)00098-8","article-title":"Rho-kinase in human neutrophils: a role in signaling for myosin light chain phosphorylation and cell migration","volume":"445","author":"Niggli","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.urology.2013.11.032_bib7","first-page":"511","article-title":"The effect of Rho-kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes","volume":"53","author":"Kawaguchi","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.urology.2013.11.032_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejphar.2004.10.040","article-title":"Preventive effect of\u00a0Y-27632, a selective Rho-kinase inhibitor, on ischemia\/reperfusion-induced acute renal failure in rats","volume":"505","author":"Teraishi","year":"2004","journal-title":"Eur J Phar"},{"key":"10.1016\/j.urology.2013.11.032_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1067\/msy.2003.59","article-title":"A\u00a0novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats","volume":"133","author":"Takeda","year":"2003","journal-title":"Surgery"},{"key":"10.1016\/j.urology.2013.11.032_bib10","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0024-3205(01)01229-2","article-title":"Pharmacological profile of hydroxyfasudil as a selective rho kinase inhibitor on ischemic brain damage","volume":"69","author":"Satoh","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.urology.2013.11.032_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-2999(03)01905-8","article-title":"Effect of the Rho-kinase inhibitors, Y-27632 and fasudil on the corpus cavernosum from diabetic mice","volume":"472","author":"B\u00fcy\u00fckaf\u015far","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.urology.2013.11.032_bib12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1464-410X.2007.07152.x","article-title":"Role of Rho-kinase in contractions of ureters from rabbits with unilateral ureteric obstruction","volume":"100","author":"Turna","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2013.11.032_bib13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/sj.bjp.0705479","article-title":"Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens","volume":"140","author":"B\u00fcy\u00fckaf\u015far","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.urology.2013.11.032_bib14","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/sj.bjp.0705109","article-title":"Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle","volume":"138","author":"Wibberley","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.urology.2013.11.032_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00345-008-0323-7","article-title":"Protective effect of trapidil on long-term histological damage in a rat model of testicular ischemia-reperfusion injury","volume":"27","author":"Bozlu","year":"2009","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2013.11.032_bib16","first-page":"1","article-title":"Testicular biopsy score count - a method for registration of spermatogenesis in human testis: normal values and results in 325 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"issue":"5 Suppl","key":"10.1016\/j.urology.2013.11.032_bib17","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.fertnstert.2008.06.008","article-title":"The effect of vascular endothelial growth factor on spermatogenesis and apoptosis in experimentally varicocele-induced adolescent rats","volume":"91","author":"Tek","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.urology.2013.11.032_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"182","author":"Lowry","year":"1951","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.urology.2013.11.032_bib19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clinbiochem.2003.10.014","article-title":"A\u00a0novel automated method to measure total antioxidant response against potent free radical reactions","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"key":"10.1016\/j.urology.2013.11.032_bib20","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A\u00a0new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.urology.2013.11.032_bib21","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.fertnstert.2005.01.144","article-title":"Protective effect of vascular endothelial growth factor on histological changes in testicular ischemia-reperfusion injury","volume":"84","author":"Tun\u00e7k\u0131ran","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.urology.2013.11.032_bib22","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00384-010-0997-3","article-title":"Rho-kinase signalling regulates CXC chemokine formation and leukocyte recruitment in\u00a0colonic ischemia-reperfusion","volume":"25","author":"Santen","year":"2010","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.urology.2013.11.032_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury","volume":"190","author":"Carden","year":"2000","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.urology.2013.11.032_bib24","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.transproceed.2006.02.057","article-title":"Taurine protects against ischemia-reperfusion injury in rabbit livers","volume":"38","author":"Tong","year":"2006","journal-title":"Transpl Proc"},{"key":"10.1016\/j.urology.2013.11.032_bib25","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cardiores.2003.12.004","article-title":"Inhibition of Rho-kinase protects the heart against ischemia\/reperfusion injury","volume":"61","author":"Bao","year":"2004","journal-title":"Cardio Res"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513015227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429513015227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T22:57:23Z","timestamp":1746140243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429513015227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0090429513015227"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2013.11.032","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}