{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:07:31Z","timestamp":1788955651186,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.urology.2014.01.018","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T21:41:49Z","timestamp":1398116509000},"page":"1030-1034","source":"Crossref","is-referenced-by-count":52,"title":["Ulcerative and Nonulcerative Forms of Bladder Pain Syndrome\/Interstitial Cystitis Do Not Differ in Symptom Intensity or Response to Onabotulinum Toxin A"],"prefix":"10.1016","volume":"83","author":[{"given":"Rui","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Dinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2014.01.018_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"Van de Merwe","year":"2008","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/nau.22202","article-title":"Chronic pelvic pain syndrome\/bladder pain syndrome: taking stock, looking ahead: ICI-RS 2011","volume":"31","author":"Hanno","year":"2012","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.urology.2014.01.018_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.urology.2011.04.030","article-title":"Are ulcerative and nonulcerative interstitial cystitis\/painful bladder syndrome 2 distinct diseases? A study of coexisting conditions","volume":"78","author":"Peters","year":"2011","journal-title":"Urology"},{"key":"10.1016\/j.urology.2014.01.018_bib4","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00192-012-2003-9","article-title":"Pain in interstitial cystitis\/bladder pain syndrome: do characteristics differ in ulcerative and non-ulcerative subtypes?","volume":"24","author":"Killinger","year":"2013","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.urology.2014.01.018_bib5","first-page":"2470","article-title":"Toward a precise definition of interstitial cystitis: further evidence of differences in classic and nonulcer disease","volume":"167","author":"Peeker","year":"2002","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/nau.22445","article-title":"Targets for botulinum toxin in the lower urinary tract","volume":"33","author":"Cruz","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.urology.2014.01.018_bib7","first-page":"1529","article-title":"Intravesical botulinum toxin A administration produces analgesia against acetic acid induced bladder pain response in rats","volume":"172","author":"Chuang","year":"2004","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib8","first-page":"1138","article-title":"Botulinum toxin type a inhibits calcitonin gene-related peptide release from isolated rat bladder","volume":"175","author":"Rapp","year":"2006","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.eururo.2010.02.031","article-title":"Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome\/interstitial cystitis","volume":"58","author":"Pinto","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib10","first-page":"1","article-title":"Comparison of intravesical botulinum toxin type A injections plus hydrodistension with hydrodistension alone for the treatment of refractory interstitial cystitis\/painful bladder syndrome","volume":"1","author":"Kuo","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2014.01.018_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.eururo.2011.07.069","article-title":"Contemporary management of the painful bladder: a systematic review","volume":"61","author":"Giannantoni","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib12","first-page":"548","article-title":"Persistent therapeutic effect of repeated injections of onabotulinum toxin a in refractory bladder pain syndrome\/interstitial cystitis","volume":"189","author":"Pinto","year":"2013","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/S1569-9056(12)60269-3","article-title":"Ulcerative and non-ulcerative forms of bladder pain syndrome\/IC do not differ in the intensity of LUTS and respond similarly to intra-trigonal onabotulinum type a injections","volume":"11","author":"Pinto","year":"2012","journal-title":"Eur Urol Suppl"},{"key":"10.1016\/j.urology.2014.01.018_bib14","first-page":"e333","article-title":"Urinary neurotrophic factors in bladder pain syndrome\/interstitial cystitis","volume":"187","author":"Pinto","year":"2012","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib15","first-page":"359","article-title":"Urinary neurotrophic factors in healthy individuals and patients with overactive bladder","volume":"189","author":"Antunes-Lopes","year":"2013","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib16","first-page":"87","article-title":"Discrimination between the ulcerous and the nonulcerous forms of interstitial cystitis by noninvasive findings","volume":"155","author":"Koziol","year":"1996","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib17","first-page":"2243","article-title":"Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis","volume":"187","author":"Tyagi","year":"2012","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib18","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/j.1526-4637.2011.01245.x","article-title":"Treatment of refractory pain with botulinum toxins\u2014an evidence-based review","volume":"12","author":"Jabbari","year":"2011","journal-title":"Pain Med"},{"key":"10.1016\/j.urology.2014.01.018_bib19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0306-4522(01)00496-1","article-title":"Vanilloid receptor 1 expression in the rat urinary tract","volume":"109","author":"Avelino","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.urology.2014.01.018_bib20","first-page":"1121","article-title":"Effect of onabotulinum toxin A on intramural parasympathetic ganglia: an experimental study in the guinea pig bladder","volume":"187","author":"Coelho","year":"2012","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib21","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.eururo.2009.12.022","article-title":"Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder","volume":"57","author":"Coelho","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib22","first-page":"109","article-title":"Intravesical botulinum toxin a injections do not benefit patients with ulcer type interstitial cystitis","volume":"16","author":"Lee","year":"2013","journal-title":"Pain Physician"},{"key":"10.1016\/j.urology.2014.01.018_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2012.12.044","article-title":"Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation","volume":"27","author":"Frias","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.urology.2014.01.018_bib24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroscience.2010.01.015","article-title":"Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis","volume":"166","author":"Pinto","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.urology.2014.01.018_bib25","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/j.1464-410X.2009.08675.x","article-title":"Urinary nerve growth factor level is increased in patients with interstitial cystitis\/bladder pain syndrome and decreased in responders to treatment","volume":"104","author":"Liu","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2014.01.018_bib26","doi-asserted-by":"crossref","first-page":"E422","DOI":"10.1111\/j.1464-410X.2012.11187.x","article-title":"Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input","volume":"110","author":"Frias","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2014.01.018_bib27","first-page":"1716","article-title":"Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis","volume":"185","author":"Evans","year":"2011","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/cne.21535","article-title":"Expression of receptors for glial cell line-derived neurotrophic factor family ligands in sacral spinal cord reveals separate targets of pelvic afferent fibers","volume":"506","author":"Forrest","year":"2008","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.urology.2014.01.018_bib29","first-page":"438","article-title":"Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients","volume":"161","author":"Okragly","year":"1999","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.urology.2014.01.018_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/nau.22438","article-title":"Neurotrophins in bladder function: What do we know and where do we go from here?","volume":"33","author":"Cruz","year":"2013","journal-title":"Neurourol Urodyn"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429514000636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429514000636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T19:26:26Z","timestamp":1538681186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429514000636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0090429514000636"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2014.01.018","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}