{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:22:13Z","timestamp":1783660933468,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.urology.2017.02.029","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T07:32:08Z","timestamp":1488267128000},"page":"191-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis\/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial"],"prefix":"10.1016","volume":"103","author":[{"given":"Florian M.E.","family":"Wagenlehner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.W. Olivier","family":"van Till","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos G.A.","family":"Houbiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynaldo V.","family":"Martina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk P.","family":"Cerneus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost H.J.M.","family":"Melis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Majek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egils","family":"Vjaters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrikas","family":"Ramonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Shoskes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Curtis","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2017.02.029_bib0010","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00345-013-1121-4","article-title":"Understanding chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS)","volume":"31","author":"Nickel","year":"2013","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0015","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00345-013-1062-y","article-title":"Management of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS): the studies, the evidence, and the impact","volume":"31","author":"Nickel","year":"2013","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0020","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/3-540-26573-2_12","article-title":"Retrograde signalling by endocannabinoids","volume":"168","author":"Vaughan","year":"2005","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.urology.2017.02.029_bib0025","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0165-6147(00)01805-8","article-title":"Modulation of transmitter release via presynaptic cannabinoid receptors","volume":"22","author":"Schlicker","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.urology.2017.02.029_bib0030","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1098\/rstb.2000.0787","article-title":"The neurobiology and evolution of cannabinoid signalling","volume":"356","author":"Elphick","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.urology.2017.02.029_bib0035","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/j.1464-410X.2010.09583.x","article-title":"Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation","volume":"108","author":"Merriam","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2017.02.029_bib0040","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/MJT.0b013e3180a5e581","article-title":"The future of cannabinoids as analgesic agents: a pharmacologic, pharmacokinetic, and pharmacodynamic overview","volume":"14","author":"McCarberg","year":"2007","journal-title":"Am J Ther"},{"key":"10.1016\/j.urology.2017.02.029_bib0045","author":"Engeler"},{"key":"10.1016\/j.urology.2017.02.029_bib0050","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0022-5347(05)68562-X","article-title":"The National Institutes of Health Chronic Prostatitis Symptom Index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network","volume":"162","author":"Litwin","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0055","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11136-005-1317-1","article-title":"Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)","volume":"15","author":"Propert","year":"2006","journal-title":"Qual Life Res"},{"key":"10.1016\/j.urology.2017.02.029_bib0060","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jval.2014.09.002","article-title":"Validation of the Patient Perception of Intensity of Urgency Scale in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia","volume":"17","author":"Mathias","year":"2014","journal-title":"Value Health"},{"key":"10.1016\/j.urology.2017.02.029_bib0065","series-title":"Manual for the Profile of Mood States","author":"McNair","year":"1971"},{"key":"10.1016\/j.urology.2017.02.029_bib0070","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1001\/archpsyc.1990.01810220015002","article-title":"Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation","volume":"47","author":"Rickels","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.urology.2017.02.029_bib0075","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1056\/NEJMra1510061","article-title":"Adaptive designs for clinical trials","volume":"375","author":"Bhatt","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urology.2017.02.029_bib0080","series-title":"Bayesian Adaptive Methods for Clinical Trials","author":"Berry","year":"2010"},{"key":"10.1016\/j.urology.2017.02.029_bib0085","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1016\/j.pain.2012.04.020","volume":"153","author":"Huggins","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.urology.2017.02.029_bib0090","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.eururo.2012.10.042","article-title":"National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronic prostatitis\/chronic pelvic pain syndrome","volume":"63","author":"Wagenlehner","year":"2013","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0095","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1056\/NEJMoa0803240","article-title":"Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome","volume":"359","author":"Nickel","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urology.2017.02.029_bib0100","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.juro.2011.03.028","article-title":"Silodosin for men with chronic prostatitis\/chronic pelvic pain syndrome: results of a phase II multicenter, double-blind, placebo controlled study","volume":"186","author":"Nickel","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0105","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.eururo.2009.05.046","article-title":"A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study","volume":"56","author":"Wagenlehner","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0110","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s00345-014-1247-z","article-title":"Immunostimulation in chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS): a one-year prospective, double-blind, placebo-controlled study","volume":"32","author":"Wagenlehner","year":"2014","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0115","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1001\/archinternmed.2010.319","article-title":"Pregabalin for the treatment of men with chronic prostatitis\/chronic pelvic pain syndrome: a randomized controlled trial","volume":"170","author":"Pontari","year":"2010","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.urology.2017.02.029_bib0120","doi-asserted-by":"publisher","first-page":"581","DOI":"10.7326\/0003-4819-141-8-200410190-00005","article-title":"Ciprofloxacin or tamsulosin in men with chronic prostatitis\/chronic pelvic pain syndrome: a randomized, double-blind trial","volume":"141","author":"Alexander","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.urology.2017.02.029_bib0125","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.urology.2009.09.007","article-title":"Efficacy and tolerability of fesoterodine in men with overactive bladder: a pooled analysis of 2 phase III studies","volume":"75","author":"Herschorn","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.urology.2017.02.029_bib0130","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrurol.2016.110","article-title":"The endocannabinoid system\u2014a target for the treatment of LUTS?","volume":"13","author":"Hedlund","year":"2016","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.urology.2017.02.029_bib0135","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1177\/1352458510378020","article-title":"Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis","volume":"16","author":"Kavia","year":"2010","journal-title":"Mult Scler"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429517301735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429517301735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:29:40Z","timestamp":1536020980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429517301735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":26,"alternative-id":["S0090429517301735"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2017.02.029","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis\/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2017.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}