{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:31:47Z","timestamp":1782912707282,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 102-2314-B-030-006"],"award-info":[{"award-number":["NSC 102-2314-B-030-006"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cardinal Tien Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["CTH-102-1-2A09"],"award-info":[{"award-number":["CTH-102-1-2A09"]}]},{"name":"Cardinal Tien Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["CTH-105A-2F03"],"award-info":[{"award-number":["CTH-105A-2F03"]}]},{"name":"Cardinal Tien Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["106-CTH-FJU-06"],"award-info":[{"award-number":["106-CTH-FJU-06"]}]},{"name":"Cardinal Tien Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["CTH106A-2B06"],"award-info":[{"award-number":["CTH106A-2B06"]}]},{"name":"Cathay General Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["105-CGH-FJU-03"],"award-info":[{"award-number":["105-CGH-FJU-03"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.urology.2017.10.008","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T21:01:01Z","timestamp":1508187661000},"page":"98-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Spontaneous Regeneration of Nerve Fiber and Irreversibility of Corporal Smooth Muscle Fibrosis After Cavernous Nerve Crush Injury: Evidence From Serial Transmission Electron Microscopy and Intracavernous Pressure"],"prefix":"10.1016","volume":"118","author":[{"given":"Yi-No","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hou","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Sun","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2017.10.008_bib0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrurol.2014.42","article-title":"Prostate cancer in Asian men","volume":"11","author":"Ito","year":"2014","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0015","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/andr.12060","article-title":"Have rates of erectile dysfunction improved within the past 17 years after radical analysis of the control arms of prospective randomized prostatectomy? A systematic analysis of the control arms of prospective randomized trials on penile rehabilitation","volume":"3","author":"Schauer","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.urology.2017.10.008_bib0020","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/01.ju.0000086947.00547.49","article-title":"Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy","volume":"170","author":"Brock","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0025","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0022-5347(17)38512-9","article-title":"Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles","volume":"145","author":"Quinlan","year":"1990","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0030","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-5347(17)40926-8","article-title":"The rat as a model for the study of penile erection","volume":"141","author":"Quinlan","year":"1989","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0035","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0022-5347(17)32336-4","article-title":"The neural mechanism of apomorphine-induced erection: an experimental study by comparison with electrostimulation-induced erection in the rat model","volume":"152","author":"Paick","year":"1994","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0040","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/S0022-5347(01)67512-8","article-title":"Regeneration of nitric oxide synthase containing nerves after cavernous nerve neurotomy in the rat","volume":"153","author":"Carrier","year":"1995","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0045","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/S0022-5347(01)62304-8","article-title":"Effect of cavernous nerve freezing on protein and gene expression of nitric oxide synthase in the rat penis and pelvic ganglia","volume":"160","author":"El-Sakka","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0050","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/jsm.12522","article-title":"Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats","volume":"11","author":"Hannan","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2017.10.008_bib0055","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/01.ju.0000089775.88825.ec","article-title":"Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury","volume":"171","author":"Burnett","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0060","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1743-6109.2005.00158.x","article-title":"Functional sequelae of cavernous nerve injury in the rat: is there model dependency","volume":"3","author":"Mullerad","year":"2006","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2017.10.008_bib0065","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1089\/end.2007.9834","article-title":"Overcoming obstacles: nerve-sparing issues in radical prostatectomy","volume":"22","author":"Ahlering","year":"2008","journal-title":"J Endourol"},{"key":"10.1016\/j.urology.2017.10.008_bib0070","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4111\/kju.2011.52.8.560","article-title":"Spontaneous recovery of cavernous nerve crush injury","volume":"52","author":"Kim","year":"2011","journal-title":"Korean J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0075","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/j.1939-4640.2003.tb02668.x","article-title":"Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum","volume":"24","author":"Leungwattanakij","year":"2003","journal-title":"J Androl"},{"key":"10.1016\/j.urology.2017.10.008_bib0080","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1111\/j.1743-6109.2012.02881.x","article-title":"The neuroprotective effect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model","volume":"9","author":"Wu","year":"2012","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2017.10.008_bib0085","doi-asserted-by":"crossref","first-page":"E294","DOI":"10.1002\/term.1806","article-title":"Optimization of platelet-rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model","volume":"10","author":"Wu","year":"2013","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.urology.2017.10.008_bib0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejphar.2010.05.049","article-title":"Changes in caveolin-1 expression and vasoreactivity in the aorta and corpus cavernosum of fructose and streptozotocin-induced diabetic rats","volume":"642","author":"El\u00e7io\u011flu","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.urology.2017.10.008_bib0095","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","article-title":"Erectile dysfunction","volume":"342","author":"Lue","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urology.2017.10.008_bib0100","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.juro.2006.03.071","article-title":"The effect of FK1706 on erectile function following bilateral cavernous nerve crush injury in a rat model","volume":"176","author":"Hayashi","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0105","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.eururo.2012.02.003","article-title":"Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury","volume":"62","author":"Qiu","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2017.10.008_bib0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF01631399","article-title":"Caverno-pudendal nervous communicating branches in the penile hilum","volume":"21","author":"Colombel","year":"1999","journal-title":"Surg Radiol Anat"},{"key":"10.1016\/j.urology.2017.10.008_bib0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0006-8993(85)90771-1","article-title":"Peripheral axotomy induces neurofilament decrease, atrophy, demyelination and degeneration of root and fasciculus gracilis fibers","volume":"340","author":"Dyck","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.urology.2017.10.008_bib0120","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1523\/JNEUROSCI.21-07-02278.2001","article-title":"Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration","volume":"21","author":"Stone","year":"2001","journal-title":"J Neurosci"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429517310816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429517310816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T21:36:10Z","timestamp":1535319370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429517310816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":23,"alternative-id":["S0090429517310816"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2017.10.008","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spontaneous Regeneration of Nerve Fiber and Irreversibility of Corporal Smooth Muscle Fibrosis After Cavernous Nerve Crush Injury: Evidence From Serial Transmission Electron Microscopy and Intracavernous Pressure","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2017.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}