{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T01:27:11Z","timestamp":1781054831299,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.urology.2019.03.018","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T17:29:10Z","timestamp":1553707750000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The Utility of Prostate Specific Antigen Density, Prostate Health Index, and Prostate Health Index Density in Predicting Positive Prostate Biopsy Outcome is Dependent on the Prostate Biopsy Methods"],"prefix":"10.1016","volume":"129","author":[{"given":"Camila","family":"Lopes Vendrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-2737","authenticated-orcid":false,"given":"Argha","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-2183","authenticated-orcid":false,"given":"David","family":"Casalino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Catalona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2019.03.018_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.urology.2019.03.018_bib0002","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.2217\/fon-2016-0178","article-title":"Risk stratification of prostate cancer: integrating multiparametric MRI, nomograms and biomarkers","volume":"12","author":"Watson","year":"2016","journal-title":"Future Oncol"},{"key":"10.1016\/j.urology.2019.03.018_bib0003","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00261-016-0975-5","article-title":"Dramatic increase in the utilization of multiparametric magnetic resonance imaging for detection and management of prostate cancer","volume":"42","author":"Oberlin","year":"2017","journal-title":"Abdom Radiol"},{"key":"10.1016\/j.urology.2019.03.018_bib0004","first-page":"201","article-title":"Association of prostate volume with incidence and aggressiveness of prostate cancer","volume":"8","author":"Al-Khalil","year":"2016","journal-title":"Res Rep Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0005","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.juro.2018.05.016","article-title":"Prostate specific antigen density as a predictor of clinically significant prostate cancer when the prostate specific antigen is in the diagnostic gray zone: defining the optimum cutoff point stratified by race and body mass index","volume":"200","author":"Aminsharifi","year":"2018","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0006","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.urology.2017.07.071","article-title":"Prostate-specific antigen density is a good predictor of upstaging and upgrading, according to the new grading system: the keys we are seeking may be already in our pocket","volume":"111","author":"Brassetti","year":"2018","journal-title":"Urology"},{"key":"10.1016\/j.urology.2019.03.018_bib0007","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/bju.13762","article-title":"Prostate health index density improves detection of clinically significant prostate cancer","volume":"120","author":"Tosoian","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2019.03.018_bib0008","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.juro.2009.08.139","article-title":"Prostate specific antigen density to predict prostate cancer upgrading in a contemporary radical prostatectomy series: a single center experience","volume":"183","author":"Magheli","year":"2010","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0009","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.juro.2010.12.032","article-title":"A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng\/ml prostate specific antigen range","volume":"185","author":"Catalona","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0010","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1515\/cclm-2012-0410","article-title":"Evaluation of [-2] proPSA and prostate health index (PHI) for the detection of prostate cancer: a systematic review and meta-analysis","volume":"51","author":"Filella","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.urology.2019.03.018_bib0011","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.juro.2014.10.121","article-title":"The prostate health index selectively identifies clinically significant prostate cancer","volume":"193","author":"Loeb","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0012","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/bju.14098","article-title":"Combining prostate health index density, magnetic resonance imaging and prior negative biopsy status to improve the detection of clinically significant prostate cancer","volume":"121","author":"Druskin","year":"2018","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2019.03.018_bib0013","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.rcl.2017.10.010","article-title":"MR imaging-targeted prostate biopsies","volume":"56","author":"Sarkar","year":"2018","journal-title":"Radiol Clin North Am"},{"key":"10.1016\/j.urology.2019.03.018_bib0014","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.urology.2017.08.019","article-title":"Prostate-specific antigen parameters and prostate health index enhance prostate cancer prediction with the in-bore 3-T magnetic resonance imaging-guided transrectal targeted prostate biopsy after negative 12-core biopsy","volume":"110","author":"Friedl","year":"2017","journal-title":"Urology"},{"key":"10.1016\/j.urology.2019.03.018_bib0015","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/bju.13318","article-title":"In-parallel comparative evaluation between multiparametric magnetic resonance imaging, prostate cancer antigen 3 and the prostate health index in predicting pathologically confirmed significant prostate cancer in men eligible for active surveillance","volume":"118","author":"Porpiglia","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.urology.2019.03.018_bib0016","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.juro.2014.01.030","article-title":"The roles of multiparametric magnetic resonance imaging, PCA3 and prostate health index-which is the best predictor of prostate cancer after a negative biopsy?","volume":"192","author":"Porpiglia","year":"2014","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0017","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/end.2017.0485","article-title":"MRI fusion-targeted transrectal prostate biopsy and the role of prostate-specific antigen density and prostate health index for the detection of clinically significant prostate cancer in southeast Asian men","volume":"31","author":"Tan","year":"2017","journal-title":"J Endourol"},{"key":"10.1016\/j.urology.2019.03.018_bib0018","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/pcan.2016.72","article-title":"Use of the prostate health index for detection of prostate cancer: results from a large academic practice","volume":"20","author":"Tosoian","year":"2017","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.urology.2019.03.018_bib0019","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/21681805.2017.1298155","article-title":"Measurement of serum isoform [-2]proPSA derivatives shows superior accuracy to magnetic resonance imaging in the diagnosis of prostate cancer in patients with a total prostate-specific antigen level of 2-10 ng\/ml","volume":"51","author":"Furuya","year":"2017","journal-title":"Scand J Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eururo.2015.08.052","article-title":"PI-RADS Prostate imaging - reporting and data system: 2015, Version 2","volume":"69","author":"Weinreb","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0021","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 international society of urological pathology (ISUP) consensus conference on gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system","volume":"40","author":"Epstein","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.urology.2019.03.018_bib0022","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.urology.2016.02.041","article-title":"Diagnostic value of guided biopsies: fusion and cognitive-registration magnetic resonance imaging versus conventional ultrasound biopsy of the prostate","volume":"92","author":"Oberlin","year":"2016","journal-title":"Urology"},{"key":"10.1016\/j.urology.2019.03.018_bib0023","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.eururo.2013.10.048","article-title":"A prospective, blinded comparison of magnetic resonance (MR) imaging-ultrasound fusion and visual estimation in the performance of MR-targeted prostate biopsy: the PROFUS trial","volume":"66","author":"Wysock","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0024","first-page":"349","article-title":"Integrated US-MR fusion images and MR targeted biopsies. What are their role and value in the detection and follow-up of prostate cancer","volume":"68","author":"Delongchamps","year":"2015","journal-title":"Arch Esp Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.eururo.2016.07.041","article-title":"Comparing three different techniques for magnetic resonance imaging-targeted prostate biopsies: a systematic review of in-bore versus magnetic resonance imaging-transrectal ultrasound fusion versus cognitive registration. is there a preferred technique?","volume":"71","author":"Wegelin","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2019.03.018_bib0026","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1148\/radiol.2017161684","article-title":"The current state of MR imaging-targeted biopsy techniques for detection of prostate cancer","volume":"285","author":"Verma","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.urology.2019.03.018_bib0027","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-targeted or standard biopsy for prostate-cancer diagnosis","volume":"378","author":"Kasivisvanathan","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urology.2019.03.018_bib0028","doi-asserted-by":"crossref","first-page":"19","DOI":"10.6004\/jnccn.2016.0004","article-title":"Prostate cancer, version 1.2016","volume":"14","author":"Mohler","year":"2016","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.urology.2019.03.018_bib0029","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.urolonc.2012.03.002","article-title":"Comparison of prostate volume measured by transrectal ultrasound and magnetic resonance imaging: is transrectal ultrasound suitable to determine which patients should undergo active surveillance?","volume":"31","author":"Weiss","year":"2013","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urology.2019.03.018_bib0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1097-0096(199605)24:4<169::AID-JCU2>3.0.CO;2-D","article-title":"Comparison of transrectal ultrasound prostatic volume estimation with magnetic resonance imaging volume estimation and surgical specimen weight in patients with benign prostatic hyperplasia","volume":"24","author":"Tewari","year":"1996","journal-title":"J Clin Ultrasound"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429519303152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429519303152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T13:04:37Z","timestamp":1663160677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429519303152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":30,"alternative-id":["S0090429519303152"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2019.03.018","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Utility of Prostate Specific Antigen Density, Prostate Health Index, and Prostate Health Index Density in Predicting Positive Prostate Biopsy Outcome is Dependent on the Prostate Biopsy Methods","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2019.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}