{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:56:32Z","timestamp":1764784592714,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.urology.2021.01.018","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T02:16:09Z","timestamp":1611108969000},"page":"264-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Efficacy and Safety of Ningmitai Capsule in Patients With Chronic Prostatitis\/Chronic Pelvic Pain Syndrome: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial"],"prefix":"10.1016","volume":"153","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2021.01.018_bib0001","first-page":"571","article-title":"Prostatitis: prevalence, health impact and quality improvement strategies","volume":"69","author":"Bajpayee","year":"2012","journal-title":"Acta Pol Pharm"},{"key":"10.1016\/j.urology.2021.01.018_bib0002","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4103\/aja.aja_97_18","article-title":"MicroRNA expression profile in chronic nonbacterial prostatitis revealed by next-generation small RNA sequencing","volume":"21","author":"Zhang","year":"2019","journal-title":"Asian J Androl"},{"key":"10.1016\/j.urology.2021.01.018_bib0003","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3389\/fimmu.2017.00898","article-title":"Immunological mechanisms underlying chronic pelvic pain and prostate inflammation in chronic pelvic pain syndrome","volume":"8","author":"Breser","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.urology.2021.01.018_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172429","article-title":"Interventions to chronic prostatitis\/chronic pelvic pain syndrome treatment. Where are we standing and what's next?","volume":"857","author":"Appiya Santharam","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.urology.2021.01.018_bib0005","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00345-019-02718-6","article-title":"Male CP\/CPPS: where do we stand?","volume":"37","author":"Doiron","year":"2019","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2021.01.018_bib0006","doi-asserted-by":"crossref","first-page":"e11840","DOI":"10.1097\/MD.0000000000011840","article-title":"Meta-analysis of the efficacy of Ningmitai capsule on the treatment of chronic prostatitis in China","volume":"97","author":"Jin","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.urology.2021.01.018_bib0007","first-page":"368","article-title":"Clinical observation of ningmitai capsule in treating diabetic urinary tract infection","volume":"04","author":"Liu L","year":"2014","journal-title":"Chin J Integr Tradit West Med Intensive Crit Care"},{"key":"10.1016\/j.urology.2021.01.018_bib0008","first-page":"169","article-title":"Ningmitai Capsules combined with doxycycline hydrochloride for Ureaplasma urealyticum positive chronic prostatitis","volume":"23","author":"Li","year":"2017","journal-title":"Natl J Androl"},{"key":"10.1016\/j.urology.2021.01.018_bib0009","first-page":"18","article-title":"Therapeutic efficiency and safety of tamsulosin combined with Ningmitai capsule in the treatment of type-III prostatitis","volume":"27","author":"Ning","year":"2018","journal-title":"Chinese J Human Sexuality"},{"key":"10.1016\/j.urology.2021.01.018_bib0010","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-5347(05)68562-X","article-title":"The national institutes of health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic prostatitis collaborative research network","volume":"162","author":"Litwin","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2021.01.018_bib0011","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4081\/aiua.2019.4.251","article-title":"The association of Boswellia resin extract and propolis derived polyphenols can improve quality of life in patients affected by prostatitis-like symptoms","volume":"91","author":"Sibona","year":"2020","journal-title":"Arch Ital Urol Androl"},{"key":"10.1016\/j.urology.2021.01.018_bib0012","first-page":"170","article-title":"Efficacy of Ningmitai capsule on type III Prostatitis","volume":"02","author":"Wang JJ","year":"2018","journal-title":"Chin J Surg Integr Tradit West Med"},{"key":"10.1016\/j.urology.2021.01.018_bib0013","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00345-010-0537-3","article-title":"Effects of a 6-month course of tamsulosin for chronic prostatitis\/chronic pelvic pain syndrome: a multicenter, randomized trial","volume":"29","author":"Chen","year":"2011","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2021.01.018_bib0014","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00345-013-1075-6","article-title":"Classification and treatment of men with chronic prostatitis\/chronic pelvic pain syndrome using the UPOINT system","volume":"31","author":"Shoskes","year":"2013","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2021.01.018_bib0015","doi-asserted-by":"crossref","first-page":"e52044","DOI":"10.1371\/journal.pone.0052044","article-title":"Clinical utility of the UPOINT phenotype system in Chinese males with chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS): a prospective study","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.urology.2021.01.018_bib0016","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.urology.2010.01.021","article-title":"Phenotypically directed multimodal therapy for chronic prostatitis\/chronic pelvic pain syndrome: a prospective study using UPOINT","volume":"75","author":"Shoskes","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.018_bib0017","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.juro.2012.07.036","article-title":"Clustering of UPOINT domains and subdomains in men with chronic prostatitis\/chronic pelvic pain syndrome and contribution to symptom severity","volume":"188","author":"Samplaski","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2021.01.018_bib0018","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.urology.2008.09.074","article-title":"Clinical phenotyping of patients with chronic prostatitis\/chronic pelvic pain syndrome and correlation with symptom severity","volume":"73","author":"Shoskes","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.018_bib0019","article-title":"The anti-inflammatory and antioxidative effects of ningmitai capsule in the experimental autoimmune prostatitis rat model","volume":"2020","author":"Chen","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.urology.2021.01.018_bib0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ucl.2011.05.003","article-title":"Quercetin for chronic prostatitis\/chronic pelvic pain syndrome","volume":"38","author":"Shoskes","year":"2011","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.urology.2021.01.018_bib0021","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0090-4295(99)00358-1","article-title":"Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial","volume":"54","author":"Shoskes","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.018_bib0022","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.eururo.2015.08.061","article-title":"Contemporary management of chronic prostatitis\/chronic pelvic pain syndrome","volume":"69","author":"Magistro","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2021.01.018_bib0023","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4155\/fmc-2016-0186","article-title":"Quercetin and derivatives: useful tools in inflammation and pain management","volume":"9","author":"Carullo","year":"2017","journal-title":"Future Med Chem"},{"key":"10.1016\/j.urology.2021.01.018_bib0024","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/pros.23536","article-title":"Quercetin protects against chronic prostatitis in rat model through NF-\u03baB and MAPK signaling pathways","volume":"78","author":"Meng","year":"2018","journal-title":"Prostate"},{"key":"10.1016\/j.urology.2021.01.018_bib0025","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s10787-019-00591-8","article-title":"The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin","volume":"27","author":"Carvalho","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.urology.2021.01.018_bib0026","first-page":"498","article-title":"Effect and mechanism of berberine hydrochloride on testosterone propionate-induced prostatic hyperplasia in mice","volume":"06","author":"Liu","year":"2020","journal-title":"Practical Med Clin"},{"key":"10.1016\/j.urology.2021.01.018_bib0027","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.fct.2014.07.019","article-title":"Luteolin decreases the attachment, invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation","volume":"72","author":"Shen","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.urology.2021.01.018_bib0028","first-page":"69","article-title":"Inhibitory effects of Ningmitai capsule and its effective monomers on inflammation-related STAT3 signaling pathway","volume":"05","author":"Wu","year":"2018","journal-title":"Acta Univ Tradit Med Sin Pharmacol Shanghai"},{"key":"10.1016\/j.urology.2021.01.018_bib0029","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/01.ju.0000117811.40279.19","article-title":"Treatment of chronic prostatitis\/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial","volume":"171","author":"Nickel","year":"2004","journal-title":"J Urol"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429521000820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429521000820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T02:39:53Z","timestamp":1758767993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429521000820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":29,"alternative-id":["S0090429521000820"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2021.01.018","relation":{},"ISSN":["0090-4295"],"issn-type":[{"type":"print","value":"0090-4295"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Ningmitai Capsule in Patients With Chronic Prostatitis\/Chronic Pelvic Pain Syndrome: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2021.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}