{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:39:36Z","timestamp":1771378776381,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.urology.2021.01.034","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T01:26:00Z","timestamp":1611883560000},"page":"9.e1-9.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Testosterone and Estrogen Repletion in a Hypogonadal Environment Improves Post-operative Angiogenesis"],"prefix":"10.1016","volume":"152","author":[{"given":"Emily","family":"Yura Gerbie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew I.","family":"Bury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne Y.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen F.","family":"Morey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias D.","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2021.01.034_bib0001","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.urology.2016.04.065","article-title":"Low serum testosterone level predisposes to artificial urinary sphincter cuff erosion","volume":"97","author":"Hofer","year":"2016","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.034_bib0002","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.urology.2018.04.018","article-title":"low serum testosterone is present in nearly half of men undergoing artificial urinary sphincter placement","volume":"118","author":"McKibben","year":"2018","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.034_bib0003","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1210\/jc.2007-1245","article-title":"Prevalence of symptomatic androgen deficiency in men","volume":"92","author":"Araujo","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.urology.2021.01.034_bib0004","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.urology.2017.02.037","article-title":"Low testosterone levels result in decreased periurethral vascularity via an androgen receptor-mediated process: pilot study in urethral stricture tissue","volume":"105","author":"Hofer","year":"2017","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.034_bib0005","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/cells8050471","article-title":"Role of angiopoietin-2 in vascular physiology and pathophysiology","volume":"8","author":"Akwii","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.urology.2021.01.034_bib0006","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1210\/en.2004-1480","article-title":"Altered levels of angiopoietin 1 and tie 2 are associated with androgen-regulated vascular regression and growth in the ventral prostate in adult mice and rats","volume":"146","author":"Johansson","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.urology.2021.01.034_bib0007","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.urology.2020.06.103","article-title":"Reversing urethral hypovascularity through testosterone and estrogen supplementation","volume":"146","author":"Yura","year":"2020","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.034_bib0008","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/en.2004-1064","article-title":"Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells","volume":"146","author":"Thomas","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.urology.2021.01.034_bib0009","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1124\/jpet.116.238212","article-title":"The glycolytic enzyme PFKFB3 is involved in estrogen-mediated angiogenesis via GPER1","volume":"361","author":"Trenti","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.urology.2021.01.034_bib0010","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3390\/ijms19030859","article-title":"Estrogen, angiogenesis, immunity and cell metabolism: solving the puzzle","volume":"19","author":"Trenti","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.urology.2021.01.034_bib0011","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/jrf.0.0420121","article-title":"Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity","volume":"42","author":"Lee","year":"1975","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.urology.2021.01.034_bib0012","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0008-6363(00)00199-1","article-title":"Intramuscular administration of estrogen may promote angiogenesis and perfusion in a rabbit model of chronic limb ischemia","volume":"49","author":"Kyriakides","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.urology.2021.01.034_bib0013","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.urology.2014.11.025","article-title":"Androgen supplementation in rats increases the inflammatory response and prolongs urethral healing","volume":"85","author":"Hofer","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.urology.2021.01.034_bib0014","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jpurol.2019.09.001","article-title":"The impact of sex hormones on genital wound healing in mice: a comparative study","volume":"15","author":"Chua","year":"2019","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.urology.2021.01.034_bib0015","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.juro.2013.02.3234","article-title":"Effect of preoperative hormonal stimulation on postoperative complication rates after proximal hypospadias repair: a systematic review","volume":"190","author":"Wright","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.urology.2021.01.034_bib0016","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa231","article-title":"Preoperative Topical Estrogen Treatment vs Placebo in 244 Children With Midshaft and Posterior Hypospadias","volume":"105","author":"Gorduza","year":"2020","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429521001060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429521001060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T02:32:50Z","timestamp":1758767570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429521001060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":16,"alternative-id":["S0090429521001060"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2021.01.034","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone and Estrogen Repletion in a Hypogonadal Environment Improves Post-operative Angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2021.01.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}