{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:40:02Z","timestamp":1751384402451,"version":"3.41.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.urology.2025.04.012","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T21:48:54Z","timestamp":1744148934000},"page":"198-205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of the Therapeutic Potential of Garcinia cambogia Alone or in Combination With Silodosin in the Management of LUTS\/BPH: A Prospective Randomized Controlled Study"],"prefix":"10.1016","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-9375","authenticated-orcid":false,"given":"Waleed","family":"El-Shaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel RA","family":"Abd-Allah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed F.","family":"El-Shafie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael M.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"El Shaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2025.04.012_bib1","series-title":"StatPearls [Internet]","article-title":"Benign prostatic hyperplasia","author":"Ng","year":"2024"},{"key":"10.1016\/j.urology.2025.04.012_bib2","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.3390\/ijms24032870","article-title":"The emerging role of cell adhesion molecules on benign prostatic hyperplasia","volume":"24","author":"Liu","year":"2023","journal-title":"Int J Molecular Sci"},{"key":"10.1016\/j.urology.2025.04.012_bib3","series-title":"Endotext [Internet]","article-title":"Androgen physiology, pharmacology, use and misuse","volume":"2000","author":"Handelsman","year":"2020"},{"key":"10.1016\/j.urology.2025.04.012_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ucl.2016.04.001","article-title":"The epidemiology of benign prostatic hyperplasia associated with lower urinary tract symptoms: prevalence and incident rates","volume":"43","author":"Egan","year":"2016","journal-title":"Urol Clin"},{"key":"10.1016\/j.urology.2025.04.012_bib5","series-title":"Geriatric Medicine: A Person Centered Evidence Based Approach","first-page":"979","article-title":"BPH and male lower urinary tract symptoms","author":"Johnson","year":"2024"},{"key":"10.1016\/j.urology.2025.04.012_bib6","first-page":"843","article-title":"Current treatment for benign prostatic hyperplasia","volume":"117","author":"Miernik","year":"2020","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"10.1016\/j.urology.2025.04.012_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/bju.15229","article-title":"Benign prostatic hyperplasia\u2013What do we know?","volume":"127","author":"Devlin","year":"2021","journal-title":"BJU international"},{"key":"10.1016\/j.urology.2025.04.012_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.15406\/ppij.2021.09.00353","article-title":"The efficacy and safety of silodosin-a review of literature","volume":"9","author":"Saygisever-Faikoglu","year":"2021","journal-title":"Pharm Pharmacol Int J"},{"key":"10.1016\/j.urology.2025.04.012_bib9","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.3390\/cancers15225465","article-title":"Unveiling disrupted lipid metabolism in benign prostate hyperplasia, prostate cancer, and metastatic patients: insights from a colombian nested case\u2013control study","volume":"15","author":"Pardo-Rodriguez","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.urology.2025.04.012_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/10942912.2023.2178458","article-title":"Nutraceutical, functional, and therapeutic properties of Garcinia cambogia: a review","volume":"26","author":"Noreen","year":"2023","journal-title":"Int J Food Prop"},{"key":"10.1016\/j.urology.2025.04.012_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fitote.2007.12.003","article-title":"Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects","volume":"79","author":"Hayamizu","year":"2008","journal-title":"Fitoterapia"},{"key":"10.1016\/j.urology.2025.04.012_bib12","series-title":"Handbook of Medical and Health Sciences in Developing Countries: Education, Practice, and Research","first-page":"1","article-title":"Benign prostatic hyperplasia","author":"Mallhi","year":"2023"},{"key":"10.1016\/j.urology.2025.04.012_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3949\/ccjm.91a.23027","article-title":"Medical management of benign prostatic hyperplasia","volume":"91","author":"MOC","year":"2024","journal-title":"Cleveland Clin J Med"},{"key":"10.1016\/j.urology.2025.04.012_bib14","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.3390\/cells11193032","article-title":"Alterations of lipid metabolism in the heart in spontaneously hypertensive rats precedes left ventricular hypertrophy and cardiac dysfunction","volume":"11","author":"Bednarski","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.urology.2025.04.012_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109392","article-title":"Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPK\u03b1 signaling pathway","volume":"113","author":"Liu","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.urology.2025.04.012_bib16","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.4103\/1673-5374.193240","article-title":"Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis","volume":"11","author":"Goudarzvand","year":"2016","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.urology.2025.04.012_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/diseases13020053","article-title":"Oxidative stress in benign prostatic hyperplasia: mechanisms, clinical relevance and therapeutic perspectives","volume":"13","author":"Kaltsas","year":"2025","journal-title":"Diseases"},{"key":"10.1016\/j.urology.2025.04.012_bib18","first-page":"17","article-title":"Garcinia cambogia for weight loss","volume":"75","author":"Haber","year":"2018","journal-title":"Bull Am Soc Hospital Pharm"},{"key":"10.1016\/j.urology.2025.04.012_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/03915603231192738","article-title":"Immediate effect of alpha-blockers in predicting LUTS improvement in BPH patients","volume":"91","author":"Sevach","year":"2024","journal-title":"Urol J"},{"key":"10.1016\/j.urology.2025.04.012_bib20","first-page":"2861","article-title":"Evolving role of silodosin for the treatment of urological disorders\u2013A narrative review","author":"Jindan","year":"2023","journal-title":"Drug Design Dev Ther"},{"key":"10.1016\/j.urology.2025.04.012_bib21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.prnil.2020.04.002","article-title":"Comparative efficacy and safety profile of 4 vs 8 mg of silodosin once daily usage in patients with benign prostatic hyperplasia\u2013related lower urinary tract symptoms divided into subgroups according to International Prostate Symptom Score severity","volume":"8","author":"Gul","year":"2020","journal-title":"Prost Int"},{"key":"10.1016\/j.urology.2025.04.012_bib22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000442995","article-title":"Transitional zone index as a predictor of the efficacy of \u03b1-blocker and 5\u03b1-reductase inhibitor combination therapy in Korean patients with benign prostatic hyperplasia","volume":"96","author":"Choi","year":"2016","journal-title":"Urol Int"},{"year":"2024","series-title":"5\u03b1-ReductaseInhibitors","author":"Salisbury","key":"10.1016\/j.urology.2025.04.012_bib23"},{"key":"10.1016\/j.urology.2025.04.012_bib24","doi-asserted-by":"crossref","DOI":"10.1177\/15593258231169381","article-title":"Dose dependent effects of aqueous extract of garcinia cambogia desr. Against letrozole induced polycystic ovarian syndrome in female adult rats with possible mechanisms exploration","volume":"21","author":"Rana","year":"2023","journal-title":"Dose-Response"},{"key":"10.1016\/j.urology.2025.04.012_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2024.103060","article-title":"The effects of Garcinia cambogia (hydroxycitric acid) on serum leptin concentrations: a systematic review and meta-analysis of randomized controlled trials","author":"Amini","year":"2024","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.urology.2025.04.012_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111754","article-title":"Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI","volume":"387","author":"Zhang","year":"2020","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.urology.2025.04.012_bib27","article-title":"Role of prostate-specific antigen (PSA) in patients with benign prostate hyperplasia","volume":"13","author":"DuvEDI","year":"2019","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.urology.2025.04.012_bib28","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1007\/s00345-020-03106-1","article-title":"Inflammation is a target of medical treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia","volume":"38","author":"De Nunzio","year":"2020","journal-title":"World J Urol"},{"key":"10.1016\/j.urology.2025.04.012_bib29","first-page":"187","volume":"55","author":"Hanai","year":"2009","journal-title":"Hinyokika Kiyo Acta Urologica Japonica"},{"key":"10.1016\/j.urology.2025.04.012_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.eursup.2003.09.008","article-title":"The hallmarks of BPH progression and risk factors","volume":"2","author":"Emberton","year":"2003","journal-title":"Eurn Urol Suppl"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429525003334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429525003334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:27:45Z","timestamp":1751383665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429525003334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":30,"alternative-id":["S0090429525003334"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2025.04.012","relation":{},"ISSN":["0090-4295"],"issn-type":[{"type":"print","value":"0090-4295"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the Therapeutic Potential of Garcinia cambogia Alone or in Combination With Silodosin in the Management of LUTS\/BPH: A Prospective Randomized Controlled Study","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2025.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}