{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:07:48Z","timestamp":1784038068479,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H050003"],"award-info":[{"award-number":["LQ21H050003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","goldjournal.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.urology.2026.04.024","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:53:54Z","timestamp":1776754434000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Vardenafil Ameliorates Hypertension-Induced Erectile Dysfunction by Suppressing the HMGB1\/RAGE\/NF-\u03baB Pathway"],"prefix":"10.1016","volume":"213","author":[{"given":"Liwei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikai","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaguo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runmiao","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urology.2026.04.024_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.pop.2019.02.006","article-title":"Erectile dysfunction","volume":"46","author":"Irwin","year":"2019","journal-title":"Prim Care"},{"key":"10.1016\/j.urology.2026.04.024_bib2","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.2174\/1381612824666180828104350","article-title":"Management of erectile dysfunction: an under-recognition of hypertension","volume":"24","author":"Koroglu","year":"2018","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.urology.2026.04.024_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.24976\/Discov.Med.202537192.12","article-title":"Analysis of risk factors associated with organic erectile dysfunction in patients with Type 2 diabetes mellitus and erectile dysfunction","volume":"37","author":"Lu","year":"2025","journal-title":"Discov Med"},{"key":"10.1016\/j.urology.2026.04.024_bib4","article-title":"Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2\/HO-1 pathway","volume":"15","author":"Luan","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.urology.2026.04.024_bib5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.sxmr.2018.02.007","article-title":"Suppression of cavernosal fibrosis in a rat model","volume":"6","author":"Cho","year":"2018","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.urology.2026.04.024_bib6","first-page":"1","article-title":"Relaxin-2 improves type I diabetes mellitus-induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis","author":"Tu","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.urology.2026.04.024_bib7","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/jsm.12522","article-title":"Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats","volume":"11","author":"Hannan","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2026.04.024_bib8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.esxm.2019.08.006","article-title":"Extracorporeal shock waves therapy delivered by aries improves erectile dysfunction in spontaneously hypertensive rats through penile tissue remodeling and neovascularization","volume":"7","author":"Assaly","year":"2019","journal-title":"Sex Med"},{"key":"10.1016\/j.urology.2026.04.024_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.31083\/j.jin2002043","article-title":"Changes of arachnoid granulations after subarachnoid hemorrhage in cynomolgus monkeys","volume":"20","author":"Jiang","year":"2021","journal-title":"J Integr Neurosci"},{"key":"10.1016\/j.urology.2026.04.024_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113006","article-title":"Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1\/RAGE\/NF-\u03baB signaling pathway","volume":"150","author":"Wang","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.urology.2026.04.024_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-38375-4","article-title":"Diacerein ameliorates cholestasis-induced liver fibrosis in rat via modulating HMGB1\/RAGE\/NF-\u03baB\/JNK pathway and endoplasmic reticulum stress","volume":"13","author":"Abdelfattah","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.urology.2026.04.024_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/ijms19010076","article-title":"High-mobility group box 1 mediates fibroblast activity via RAGE-MAPK and NF-\u03baB signaling in Keloid scar formation","volume":"19","author":"Kim","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.urology.2026.04.024_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/andr.13203","article-title":"Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1\/RAGE\/NF-kB pathway","volume":"11","author":"Sun","year":"2023","journal-title":"Andrology"},{"key":"10.1016\/j.urology.2026.04.024_bib14","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.3390\/cells10123502","article-title":"Vardenafil activity in lung fibrosis and in vitro synergy with nintedanib","volume":"10","author":"Bourne","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.urology.2026.04.024_bib15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.urology.2006.05.011","article-title":"Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat","volume":"68","author":"Ferrini","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.urology.2026.04.024_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10238-010-0109-2","article-title":"Vardenafil, an inhibitor of phosphodiesterase-5, blocks advanced glycation end product (AGE)-induced up-regulation of monocyte chemoattractant protein-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression via elevation of cGMP","volume":"11","author":"Ishibashi","year":"2011","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.urology.2026.04.024_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.52312\/jdrs.2021.72","article-title":"Effects of different vardenafil doses on bone healing in a rat fracture model","volume":"32","author":"Atc\u0131","year":"2021","journal-title":"Jt Dis Relat Surg"},{"key":"10.1016\/j.urology.2026.04.024_bib18","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.eururo.2011.07.052","article-title":"Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: a proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure","volume":"60","author":"Oudot","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.urology.2026.04.024_bib19","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/j.1743-6109.2009.01249.x","article-title":"Vardenafil modulates bladder contractility through cGMP-mediated inhibition of RhoA\/Rho kinase signaling pathway in spontaneously hypertensive rats","volume":"6","author":"Morelli","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2026.04.024_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1743-6109.2009.01558.x","article-title":"Acute vardenafil administration improves bladder oxygenation in spontaneously hypertensive rats","volume":"7","author":"Morelli","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2026.04.024_bib21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2164\/jandrol.111.014456","article-title":"The TGF-\u03b21\/Smad\/CTGF pathway and corpus cavernosum fibrous-muscular alterations in rats with streptozotocin-induced diabetes","volume":"33","author":"Zhou","year":"2012","journal-title":"J Androl"},{"key":"10.1016\/j.urology.2026.04.024_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/0970-1591.32057","article-title":"Erectile dysfunction among hypertensive men in a rapidly developing country","volume":"23","author":"Bener","year":"2007","journal-title":"Indian J Urol"},{"key":"10.1016\/j.urology.2026.04.024_bib23","first-page":"925","article-title":"Phenotypic transformation of corpus cavernosum smooth muscle cells in hypertensive rats","volume":"29","author":"Wei","year":"2009","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.urology.2026.04.024_bib24","first-page":"126","article-title":"Genetic polymorphisms and endothelial dysfunction in patients with essential hypertension: a cross-sectional case-control study","volume":"13","author":"Demirel","year":"2005","journal-title":"Neth Heart J"},{"key":"10.1016\/j.urology.2026.04.024_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70210","article-title":"Rnf40 exacerbates hypertension-induced cerebrovascular endothelial barrier dysfunction by ubiquitination and degradation of parkin","volume":"31","author":"Kou","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.urology.2026.04.024_bib26","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.2165\/00003495-200363230-00010","article-title":"Vardenafil: a review of its use in erectile dysfunction","volume":"63","author":"Keating","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.urology.2026.04.024_bib27","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuint.2004.03.016","article-title":"Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)","volume":"45","author":"Corbin","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.urology.2026.04.024_bib28","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/CIRCULATIONAHA.120.049606","article-title":"Red blood cell and endothelial eNOS independently regulate circulating nitric oxide metabolites and blood pressure","volume":"144","author":"Leo","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.urology.2026.04.024_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"Sims","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.urology.2026.04.024_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbadis.2016.11.006","article-title":"The role of alpha-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling","volume":"1863","author":"Shinde","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.urology.2026.04.024_bib31","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jsxm.2016.02.164","article-title":"Taurine supplementation improves erectile function in rats with streptozotocin-induced Type 1 diabetes via amelioration of penile fibrosis and endothelial dysfunction","volume":"13","author":"Ruan","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.urology.2026.04.024_bib32","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.juro.2014.10.099","article-title":"Restoration of erectile function by suppression of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rho-kinase inhibitors in a rat model of cavernous nerve injury","volume":"193","author":"Cho","year":"2015","journal-title":"J Urol"}],"container-title":["Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429526002517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090429526002517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:43:27Z","timestamp":1784036607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090429526002517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S0090429526002517"],"URL":"https:\/\/doi.org\/10.1016\/j.urology.2026.04.024","relation":{},"ISSN":["0090-4295"],"issn-type":[{"value":"0090-4295","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vardenafil Ameliorates Hypertension-Induced Erectile Dysfunction by Suppressing the HMGB1\/RAGE\/NF-\u03baB Pathway","name":"articletitle","label":"Article Title"},{"value":"Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urology.2026.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}