{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:24:37Z","timestamp":1776954277156,"version":"3.51.4"},"reference-count":13,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.urolonc.2010.02.006","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T04:55:41Z","timestamp":1283403341000},"page":"290-293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Feasibility and effects of high-dose hypofractionated radiation therapy and simultaneous multi-kinase inhibition with sunitinib in progressive metastatic renal cell cancer"],"prefix":"10.1016","volume":"30","author":[{"given":"Michael","family":"Staehler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Haseke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Nuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Roosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Stief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Wilkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2010.02.006_bib1","series-title":"SEER Cancer Statistics Review, 1975\u20132005, National Cancer Institute","year":"2008"},{"key":"10.1016\/j.urolonc.2010.02.006_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMoa065044","article-title":"Sunitinib vs. interferon \u03b1 in metastatic renal-cell carcinoma","volume":"356","author":"Motzer","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urolonc.2010.02.006_bib3","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3346\/jkms.2008.23.4.740","article-title":"Hypofractionated high-dose intensity-modulated radiotherapy (60 Gy at 2.5 Gy per fraction) for recurrent renal cell carcinoma: A case report","volume":"23","author":"Cho","year":"2008","journal-title":"J Korean Med Sci"},{"issue":"3 Pt 1","key":"10.1016\/j.urolonc.2010.02.006_bib4","first-page":"746","article-title":"Palliative irradiation for focally symptomatic metastatic renal cell carcinoma: Support for dose escalation based on a biological model","volume":"158","author":"DiBiase","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2010.02.006_bib5","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/cncr.21410","article-title":"A phase II trial of palliative radiotherapy for metastatic renal cell carcinoma","volume":"104","author":"Lee","year":"2005","journal-title":"Cancer"},{"issue":"12 Suppl","key":"10.1016\/j.urolonc.2010.02.006_bib6","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1002\/(SICI)1097-0142(19971215)80:12+<2519::AID-CNCR26>3.0.CO;2-E","article-title":"Radiobiologic studies of radioimmunotherapy and external beam radiotherapy in vitro and in vivo in human renal cell carcinoma xenografts","volume":"80","author":"Ning","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.urolonc.2010.02.006_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00345-004-0479-8","article-title":"Treatment of bone metastases and local recurrence from renal cell carcinoma with immunochemotherapy and radiation","volume":"23","author":"Brinkmann","year":"2005","journal-title":"World J Urol"},{"key":"10.1016\/j.urolonc.2010.02.006_bib8","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1158\/0008-5472.CAN-03-3369","article-title":"Differential activation of the phosphatidylinositol 3\u2032-kinase\/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells","volume":"64","author":"Zingg","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.urolonc.2010.02.006_bib9","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1091\/mbc.10.8.2493","article-title":"Radiation-induced release of transforming growth factor \u03b1 activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death","volume":"10","author":"Dent","year":"1999","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.urolonc.2010.02.006_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3816\/CGC.2007.n.007","article-title":"Radiation therapy and sorafenib: Clinical data and rationale for the combination in metastatic renal cell carcinoma","volume":"5","author":"Kasibhatla","year":"2007","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2010.02.006_bib11","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1200\/JCO.2007.15.8451","article-title":"Bowel perforation after radiotherapy in a patient receiving sorafenib","volume":"26","author":"Peters","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.urolonc.2010.02.006_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5070\/D30GH135CX","article-title":"Complete response in a cutaneous facial metastatic nodule from renal cell carcinoma after hypofractionated radiotherapy","volume":"13","author":"Gay","year":"2007","journal-title":"Dermatol Online J"},{"key":"10.1016\/j.urolonc.2010.02.006_bib13","first-page":"4599","article-title":"Hypofractionated radiotherapy with concomitant sunitinib\u2014is there a radiosensitizing effect?","volume":"16","author":"Taussky","year":"2009","journal-title":"Can J Urol"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143910000475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143910000475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:57:32Z","timestamp":1761040652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143910000475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1078143910000475"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2010.02.006","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility and effects of high-dose hypofractionated radiation therapy and simultaneous multi-kinase inhibition with sunitinib in progressive metastatic renal cell cancer","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2010.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}