{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:34:48Z","timestamp":1792647288567,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","award":["DOH100-TD-C-111-001"],"award-info":[{"award-number":["DOH100-TD-C-111-001"]}],"id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","award":["DOH99-TD-C-111-001"],"award-info":[{"award-number":["DOH99-TD-C-111-001"]}],"id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.urolonc.2012.01.015","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T23:36:46Z","timestamp":1331595406000},"page":"1367-1377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["\u03b1B-Crystallin in clear cell renal cell carcinoma: Tumor progression and prognostic significance"],"prefix":"10.1016","volume":"31","author":[{"given":"Pei-Yin","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh-Horng","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Liang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Chi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Kuen","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2012.01.015_bib1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1056\/NEJM199609193351207","article-title":"Renal-cell carcinoma","volume":"335","author":"Motzer","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urolonc.2012.01.015_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10147-005-0551-4","article-title":"Early renal cell cancer","volume":"11","author":"Tomita","year":"2006","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib3","first-page":"124","article-title":"Contemporary approach to the classification of renal epithelial tumors","volume":"27","author":"Reuter","year":"2000","journal-title":"Semin Oncol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib4","series-title":"Renal cell carcinoma: Molecular targets and clinical applications","author":"Bukowski","year":"2009"},{"key":"10.1016\/j.urolonc.2012.01.015_bib5","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S1470-2045(09)70240-2","article-title":"Resistance to targeted therapy in renal-cell carcinoma","volume":"10","author":"Rini","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s002400050075","article-title":"Different concentrations of two small stress proteins, \u03b1B crystallin and HSP27 in human urological tumor tissues","volume":"26","author":"Takashi","year":"1998","journal-title":"Urol Res"},{"key":"10.1016\/j.urolonc.2012.01.015_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/path.1711660110","article-title":"\u03b1B crystallin expression in non-lenticular tissues and selective presence in ubiquitinated inclusion bodies in human disease","volume":"166","author":"Lowe","year":"1992","journal-title":"J Pathol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0959-440X(99)00048-2","article-title":"Small heat-shock proteins and their potential role in human disease","volume":"10","author":"Clark","year":"2000","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1089\/ars.2005.7.404","article-title":"Small heat shock proteins HSP27 and \u03b1B-crystallin: Cytoprotective and oncogenic functions","volume":"7","author":"Parcellier","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.urolonc.2012.01.015_bib10","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"S\u00f8rlie","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.urolonc.2012.01.015_bib11","doi-asserted-by":"crossref","first-page":"10393","DOI":"10.1073\/pnas.1732912100","article-title":"Breast cancer classification and prognosis based on gene expression profiles from a population-based study","volume":"100","author":"Sotiriou","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.urolonc.2012.01.015_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4049\/jimmunol.154.1.363","article-title":"Constitutive expression of human hsp27, Drosophila hsp27, or human \u03b1B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts","volume":"154","author":"Mehlen","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1379\/CSC-107R.1","article-title":"Differential expression of \u03b1B-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific \u03b1B-crystallin gene (CRYAB) silencing","volume":"10","author":"Mineva","year":"2005","journal-title":"Cell Stress Chaperones"},{"issue":"Suppl","key":"10.1016\/j.urolonc.2012.01.015_bib14","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1007\/s10549-005-0144-y","article-title":"The future of breast cancer: The role of prognostic factors","volume":"89","author":"Gradishar","year":"2005","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.urolonc.2012.01.015_bib15","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1074\/jbc.M413382200","article-title":"The small heat shock protein \u03b1B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3","volume":"280","author":"Kamradt","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.urolonc.2012.01.015_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10549-007-9796-0","article-title":"\u03b1B-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer","volume":"111","author":"Ivanov","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.urolonc.2012.01.015_bib17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bbrc.2005.08.149","article-title":"Retardation of cell growth by avian reovirus p17 through the activation of p53 pathway","volume":"336","author":"Liu","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.urolonc.2012.01.015_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/mc.1066","article-title":"Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells","volume":"32","author":"Lin","year":"2001","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.urolonc.2012.01.015_bib19","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1074\/jbc.M414320200","article-title":"Peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesis","volume":"280","author":"Sulochana","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.urolonc.2012.01.015_bib20","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/sj.jcbfm.9600117","article-title":"Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate","volume":"25","author":"Pilorget","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.urolonc.2012.01.015_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/mc.20015","article-title":"Differential protein profiling in renal-cell carcinoma","volume":"40","author":"Shi","year":"2004","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.urolonc.2012.01.015_bib22","first-page":"48","article-title":"Identification of \u03b1B-crystallin, a biomarker of renal cell carcinoma by SELDI-TOF MS","volume":"23","author":"Holcakova","year":"2008","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.urolonc.2012.01.015_bib23","doi-asserted-by":"crossref","unstructured":"Baldewijns MM, van Vlodrop IJ, Vermeulen PB, et al. VHL and HIF signalling in renal cell carcinogenesis. J Pathol;221:125\u201338.","DOI":"10.1002\/path.2689"},{"key":"10.1016\/j.urolonc.2012.01.015_bib24","doi-asserted-by":"crossref","unstructured":"Kroeze SG, Vermaat JS, van Brussel A, et al. Expression of nuclear FIH independently predicts overall survival of clear cell renal cell carcinoma patients. Eur J Cancer;46:3375\u201382.","DOI":"10.1016\/j.ejca.2010.07.018"},{"key":"10.1016\/j.urolonc.2012.01.015_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ccr.2010.09.009","article-title":"T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation","volume":"18","author":"Feng","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.urolonc.2012.01.015_bib26","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1038\/sj.onc.1202569","article-title":"The inhibitors of apoptosis (IAPs) and their emerging role in cancer","volume":"17","author":"LaCasse","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.urolonc.2012.01.015_bib27","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1091\/mbc.e05-01-0010","article-title":"Calcium-activated RAF\/MEK\/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by \u03b1B-crystallin through inhibition of RAS activation","volume":"16","author":"Li","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.urolonc.2012.01.015_bib28","first-page":"500","article-title":"The clinicopathological roles of \u03b1B-crystallin and p53 expression in patients with head and neck squamous cell carcinoma","volume":"40","author":"King-Yin","year":"2008","journal-title":"Pathology"},{"key":"10.1016\/j.urolonc.2012.01.015_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.anndiagpath.2007.02.004","article-title":"\u03b1B-crystallin: A novel marker of invasive basal-like and metaplastic breast carcinomas","volume":"12","author":"Sitterding","year":"2008","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1172\/JCI25888","article-title":"\u03b1B-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer","volume":"116","author":"Moyano","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.urolonc.2012.01.015_bib31","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/01.MLG.0000164715.86240.55","article-title":"\u03b1B-crystallin, a new independent marker for poor prognosis in head and neck cancer","volume":"115","author":"Chin","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.urolonc.2012.01.015_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.humpath.2008.09.002","article-title":"Expression and prognostic significance of the \u03b1B-crystallin gene in human hepatocellular carcinoma","volume":"40","author":"Tang","year":"2009","journal-title":"Hum Pathol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib33","doi-asserted-by":"crossref","first-page":"36876","DOI":"10.1074\/jbc.M304010200","article-title":"Hyperproliferation and p53 status of lens epithelial cells derived from \u03b1B-crystallin knockout mice","volume":"278","author":"Bai","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.urolonc.2012.01.015_bib34","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1021\/bi700149h","article-title":"Interactions between important regulatory proteins and human \u03b1B crystallin","volume":"46","author":"Ghosh","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.urolonc.2012.01.015_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yexcr.2005.01.026","article-title":"\u03b1-Crystallin localizes to the leading edges of migrating lens epithelial cells","volume":"306","author":"Maddala","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.urolonc.2012.01.015_bib36","doi-asserted-by":"crossref","unstructured":"Simpson NE, Lambert WM, Watkins R, et al. High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Cancer Res;70:8446\u201356.","DOI":"10.1158\/0008-5472.CAN-10-1590"},{"key":"10.1016\/j.urolonc.2012.01.015_bib37","doi-asserted-by":"crossref","unstructured":"Castilla C, Congregado B, Conde JM, et al. Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer. Urology;76:e1011\u20131016.","DOI":"10.1016\/j.urology.2010.05.045"},{"key":"10.1016\/j.urolonc.2012.01.015_bib38","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1158\/0008-5472.CAN-09-3252","article-title":"Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD","volume":"70","author":"Zoubeidi","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.urolonc.2012.01.015_bib39","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1007\/s11033-009-9903-x","article-title":"Identification of HSP27 as a potential tumor marker for colorectal cancer by the two-dimensional polyacrylamide gel electrophoresis","volume":"37","author":"Liu","year":"2010","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.urolonc.2012.01.015_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/excr.1996.0070","article-title":"Heat shock proteins increase resistance to apoptosis","volume":"223","author":"Samali","year":"1996","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.urolonc.2012.01.015_bib41","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/91.20.1758","article-title":"Hormone therapy failure in human prostate cancer: Analysis by complementary DNA and tissue microarrays","volume":"91","author":"Bubendorf","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.urolonc.2012.01.015_bib42","first-page":"1325","article-title":"Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis","volume":"23","author":"Cappello","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.urolonc.2012.01.015_bib43","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.leukres.2005.02.010","article-title":"Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia","volume":"29","author":"Thomas","year":"2005","journal-title":"Leuk Res"},{"key":"10.1016\/j.urolonc.2012.01.015_bib44","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc1716","article-title":"HSP90 and the chaperoning of cancer","volume":"5","author":"Whitesell","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.urolonc.2012.01.015_bib45","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1182\/blood-2009-10-247239","article-title":"Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias","volume":"116","author":"Bansal","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.urolonc.2012.01.015_bib46","doi-asserted-by":"crossref","unstructured":"Choi SH, Lee YJ, Seo WD, et al. Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance. Int J Radiat Oncol Biol Phys;79:1196\u2013205.","DOI":"10.1016\/j.ijrobp.2010.10.025"},{"key":"10.1016\/j.urolonc.2012.01.015_bib47","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1182\/blood-2010-04-278853","article-title":"The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP\/Grp78","volume":"117","author":"Roue","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.urolonc.2012.01.015_bib48","first-page":"177","article-title":"Chemotherapy for renal cell carcinoma","volume":"27","author":"Amato","year":"2000","journal-title":"Semin Oncol"},{"key":"10.1016\/j.urolonc.2012.01.015_bib49","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1097\/00029330-200809020-00014","article-title":"Identification of differential gene expression profiles of radioresistant lung cancer cell line established by fractionated ionizing radiation in vitro","volume":"121","author":"Xu","year":"2008","journal-title":"Chin Med J (Engl)"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143912000452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143912000452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:13:03Z","timestamp":1786450383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143912000452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1078143912000452"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2012.01.015","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b1B-Crystallin in clear cell renal cell carcinoma: Tumor progression and prognostic significance","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2012.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}