{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:51Z","timestamp":1787169771754,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.urolonc.2018.12.020","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:03:29Z","timestamp":1546985009000},"page":"282-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Depression and prostate cancer: A focused review for the clinician"],"prefix":"10.1016","volume":"37","author":[{"given":"Gagan","family":"Fervaha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Izard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Tripp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl P.","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Robert","family":"Siemens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2018.12.020_bib0001","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0002","first-page":"271","article-title":"Cancer treatment and survivorship statistics, 2016","volume":"66","author":"Miller","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0003","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrurol.2014.101","article-title":"Quality-of-life assessment tools for men with prostate cancer","volume":"11","author":"Bergman","year":"2014","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0004","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/pcan.2011.66","article-title":"Psychological aspects of prostate cancer: a clinical review","volume":"15","author":"De Sousa","year":"2012","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-3223(03)00566-3","article-title":"Depression and cancer: mechanisms and disease progression","volume":"54","author":"Spiegel","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0006","series-title":"Diagnostic and statistical manual of mental disorders: DSM-5","year":"2013"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0007","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/cncr.1984.53.s10.2243","article-title":"Measurement of depression in patients with cancer","volume":"53","author":"Endicott","year":"1984","journal-title":"Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0008","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003901","article-title":"Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates","volume":"4","author":"Watts","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0009","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S2215-0366(15)00168-6","article-title":"Patient-reported depression measures in cancer: a meta-review","volume":"2","author":"Wakefield","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/082585979100700202","article-title":"The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients","volume":"7","author":"Bruera","year":"1991","journal-title":"J Palliat Care"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0011","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/1049909117745292","article-title":"The accuracy of the Edmonton Symptom Assessment System for the assessment of depression in patients with cancer: a systematic review and meta-analysis","volume":"35","author":"Boonyathee","year":"2018","journal-title":"Am J Hosp Palliat Care"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0012","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0013","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0014","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0015","first-page":"26","article-title":"Measuring depression in prostate cancer patients: does the scale used make a difference?","author":"Sharpley","year":"2017","journal-title":"Eur J Cancer Care"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0016","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1176\/ajp.154.5.674","article-title":"\"Are you depressed?\" Screening for depression in the terminally ill","volume":"154","author":"Chochinov","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0017","first-page":"600","article-title":"Use of distress and depression thermometers to measure psychosocial morbidity among southern European cancer patients","volume":"13","author":"Gil","year":"2005","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0018","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1200\/JCO.2013.52.4611","article-title":"Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation","volume":"32","author":"Andersen","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0019","doi-asserted-by":"crossref","first-page":"E191","DOI":"10.1503\/cmaj.110829","article-title":"Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis","volume":"184","author":"Manea","year":"2012","journal-title":"CMAJ"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0020","doi-asserted-by":"crossref","first-page":"k1415","DOI":"10.1136\/bmj.k1415","article-title":"Depression and anxiety in patients with cancer","volume":"361","author":"Pitman","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0021","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1176\/appi.psy.41.2.85","article-title":"Biopsychosocial aspects of prostate cancer","volume":"41","author":"Kunkel","year":"2000","journal-title":"Psychosomatics"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0022","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0023","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.urolonc.2014.05.005","article-title":"Mental health outcomes in elderly men with prostate cancer","volume":"32","author":"Ravi","year":"2014","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0024","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1176\/appi.ajp.160.6.1147","article-title":"Risk factors for depression among elderly community subjects: a systematic review and meta-analysis","volume":"160","author":"Cole","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/0284186X.2016.1266090","article-title":"Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review","volume":"56","author":"Caruso","year":"2017","journal-title":"Acta Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0026","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/pon.4230","article-title":"Psychological adjustment after breast cancer: a systematic review of longitudinal studies","volume":"26","author":"Brandao","year":"2017","journal-title":"Psychooncology"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0027","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/pon.3657","article-title":"A longitudinal study on the impact of active surveillance for prostate cancer on anxiety and distress levels","volume":"24","author":"Venderbos","year":"2015","journal-title":"Psychooncology"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0028","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa1606221","article-title":"Patient-reported outcomes after monitoring, surgery, or radiotherapy for prostate cancer","volume":"375","author":"Donovan","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0029","doi-asserted-by":"crossref","first-page":"664e1","DOI":"10.1016\/j.urolonc.2017.07.016","article-title":"Association of androgen deprivation therapy and depression in the treatment of prostate cancer: a systematic review and meta-analysis","volume":"35","author":"Nead","year":"2017","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000197","article-title":"Immediate risk for cardiovascular events and suicide following a prostate cancer diagnosis: prospective cohort study","volume":"6","author":"Fall","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0031","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jnci\/djp537","article-title":"Immediate risk of suicide and cardiovascular death after a prostate cancer diagnosis: cohort study in the United States","volume":"102","author":"Fang","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0032","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.eururo.2009.10.035","article-title":"Suicide risk in men with prostate-specific antigen-detected early prostate cancer: a nationwide population-based cohort study from PCBaSe Sweden","volume":"57","author":"Bill-Axelson","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0033","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/cncr.29274","article-title":"Factors associated with suicide in patients with genitourinary malignancies","volume":"121","author":"Klaassen","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0034","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/bju.13257","article-title":"Suicide and accidental deaths among patients with non-metastatic prostate cancer","volume":"118","author":"Dalela","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0035","article-title":"Increased risk of suicide in New South Wales men with prostate cancer: analysis of linked population-wide data","volume":"13","author":"Smith","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0036","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00019442-200503000-00004","article-title":"Prostate cancer: a significant risk factor for late-life suicide","volume":"13","author":"Llorente","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0037","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1002\/cncr.28880","article-title":"Suicidal ideation in prostate cancer survivors: understanding the role of physical and psychological health outcomes","volume":"120","author":"Recklitis","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0038","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-med-061212-171507","article-title":"Depression as a risk factor for cancer: from pathophysiological advances to treatment implications","volume":"65","author":"Currier","year":"2014","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0039","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1200\/JCO.2013.51.1048","article-title":"Effect of depression on diagnosis, treatment, and mortality of men with clinically localized prostate cancer","volume":"32","author":"Prasad","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0040","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/pon.2032","article-title":"The burden of depression in prostate cancer","volume":"21","author":"Jayadevappa","year":"2012","journal-title":"Psychooncology"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0041","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.urolonc.2011.02.002","article-title":"Pretreatment depressive symptoms and treatment modality predict post-treatment disease-specific quality of life among patients with localized prostate cancer","volume":"30","author":"Mohamed","year":"2012","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0042","doi-asserted-by":"crossref","first-page":"350","DOI":"10.7326\/M15-2570","article-title":"Nonpharmacologic versus pharmacologic treatment of adult patients with major depressive disorder: a clinical practice guideline from the American College of Physicians","volume":"164","author":"Qaseem","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0043","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1200\/JCO.2011.39.7372","article-title":"Evidence-based treatment of depression in patients with cancer","volume":"30","author":"Li","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0044","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","article-title":"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis","volume":"391","author":"Cipriani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0045","article-title":"Antidepressants for the treatment of depression in people with cancer","volume":"4","author":"Ostuzzi","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0046","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008529.pub2","article-title":"Psychosocial interventions for men with prostate cancer","author":"Parahoo","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0047","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.ejca.2011.04.022","article-title":"Psychiatric treatment in men with prostate cancer\u2013results from a Nation-wide, population-based cohort study from PCBaSe Sweden","volume":"47","author":"Bill-Axelson","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0048","first-page":"3005","article-title":"Medical comorbidity and psychotropic medication fills in older adults with breast or prostate cancer","volume":"23","author":"Jones","year":"2015","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0049","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1200\/JCO.2016.67.7690","article-title":"Use of medications for treating anxiety and depression in cancer survivors in the United States","volume":"35","author":"Hawkins","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0050","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1600-0447.2006.00890.x","article-title":"Antidepressants and sexual dysfunction","volume":"114","author":"Werneke","year":"2006","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0051","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1001\/jama.294.2.238","article-title":"Androgen deprivation therapy for prostate cancer","volume":"294","author":"Sharifi","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0052","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(09)70338-9","article-title":"Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: a double-blind, randomised trial","volume":"11","author":"Irani","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0053","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/sj.pcan.4500891","article-title":"Pilot evaluation of selective serotonin reuptake inhibitor antidepressants in hot flash patients under androgen-deprivation therapy for prostate cancer","volume":"9","author":"Naoe","year":"2006","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0054","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/pon.3781","article-title":"Interventions that may reduce depressive symptoms among prostate cancer patients: a systematic review and meta-analysis","volume":"24","author":"Newby","year":"2015","journal-title":"Psychooncology"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0055","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1200\/JCO.2016.70.5301","article-title":"Efficacy of blended cognitive behavior therapy for high fear of recurrence in breast, prostate, and colorectal cancer survivors: the SWORD study, a randomized controlled trial","volume":"35","author":"van de Wal","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0056","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/sj.bjc.6602949","article-title":"The effectiveness of treatment for depression\/depressive symptoms in adults with cancer: a systematic review","volume":"94","author":"Williams","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.urolonc.2018.12.020_bib0057","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/jnci\/djs256","article-title":"Meta-analysis of efficacy of interventions for elevated depressive symptoms in adults diagnosed with cancer","volume":"104","author":"Hart","year":"2012","journal-title":"J Natl Cancer Inst"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143918305143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143918305143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:14:27Z","timestamp":1761041667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143918305143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1078143918305143"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2018.12.020","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depression and prostate cancer: A focused review for the clinician","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2018.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}