{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:39:20Z","timestamp":1789900760212,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672510"],"award-info":[{"award-number":["81672510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.urolonc.2019.04.013","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T17:36:53Z","timestamp":1556645813000},"page":"452-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preoperative plasma IGFBP2 is associated with nodal metastasis in patients with penile squamous cell carcinoma"],"prefix":"10.1016","volume":"37","author":[{"given":"Xiheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangle","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9922-8678","authenticated-orcid":false,"given":"Jun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2019.04.013_bib0001","doi-asserted-by":"crossref","first-page":"785","DOI":"10.21037\/tau.2017.05.19","article-title":"Updates on the epidemiology and risk factors for penile cancer","volume":"6","author":"Douglawi","year":"2017","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0002","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5173\/ceju.2014.02.art2","article-title":"Metastatic penile carcinoma \u2013 an update on the current diagnosis and treatment options","volume":"67","author":"Barski","year":"2014","journal-title":"Cent Eur J Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0003","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00345-008-0274-z","article-title":"How accurate are present risk group assignment tools in penile cancer?","volume":"27","author":"Ficarra","year":"2009","journal-title":"World J Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0004","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/01.ju.0000154565.37397.4d","article-title":"Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases","volume":"173","author":"Kroon","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0005","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0022-5347(05)65169-5","article-title":"Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson Cancer Center Experience","volume":"167","author":"Bevan-Thomas","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eururo.2004.03.007","article-title":"EAU guidelines on penile cancer","volume":"46","author":"Solsona","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0007","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0022-5347(17)35222-9","article-title":"Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases","volume":"151","author":"Ornellas","year":"1994","journal-title":"J Urol"},{"issue":"May (2)","key":"10.1016\/j.urolonc.2019.04.013_bib0008","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.lungcan.2011.11.012","article-title":"Carcinoembryonic antigen (CEA) as tumor marker in lung cancer","volume":"76","author":"Grunnet","year":"2012","journal-title":"Lung Cancer"},{"issue":"May (29)","key":"10.1016\/j.urolonc.2019.04.013_bib0009","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1476-4598-13-129","article-title":"MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress","volume":"13","author":"Felder","year":"2014","journal-title":"Mol Cancer"},{"issue":"May (2)","key":"10.1016\/j.urolonc.2019.04.013_bib0010","article-title":"Clinicopathological and prognostic significance of cancer antigen 15-3 and carcinoembryonic antigen in breast cancer: a meta-analysis including 12,993 patients","volume":"2018","author":"Li","year":"2018","journal-title":"Dis Markers"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0011","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.juro.2008.07.040","article-title":"The value of squamous cell carcinoma antigen in the prognostic evaluation, treatment monitoring and followup of patients with penile cancer","volume":"180","author":"Zhu","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0012","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1464-410X.2007.06908.x","article-title":"The prognostic significance of p53, Ki-67, epithelial cadherin and matrix metalloproteinase-9 in penile squamous cell carcinoma treated with surgery","volume":"100","author":"Zhu","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0013","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/0046-8177(95)90005-5","article-title":"Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma","volume":"26","author":"Akmal","year":"1995","journal-title":"Hum Pathol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0014","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1476-4598-12-63","article-title":"Regulation of protumorigenic pathways by insulin like growth factor binding protein2 and its association along with \u03b2-catenin in breast cancer lymph node metastasis","volume":"12","author":"Sehgal","year":"2013","journal-title":"Mol Cancer"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0015","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1073\/pnas.0609139104","article-title":"Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K\/Akt pathway activation in glioblastoma and prostate cancer","volume":"104","author":"Mehrian-Shai","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0016","doi-asserted-by":"crossref","first-page":"16675","DOI":"10.1073\/pnas.0900807106","article-title":"IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas","volume":"106","author":"Moore","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0017","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/bjc.2017.199","article-title":"A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours","volume":"117","author":"Russell","year":"2017","journal-title":"Br J Cancer"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0018","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1524-4741.2008.00572.x","article-title":"IGFBP2 and IGFBP5 overexpression correlates with the lymph node metastasis in T1 breast carcinomas","volume":"14","author":"Wang","year":"2008","journal-title":"Breast J"},{"issue":"8","key":"10.1016\/j.urolonc.2019.04.013_bib0019","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708741","article-title":"Soluble stroma-related biomarkers of pancreatic cancer","volume":"10","author":"Resovi","year":"2018","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0020","doi-asserted-by":"crossref","first-page":"594","DOI":"10.6004\/jnccn.2013.0075","article-title":"Penile cancer: clinical practice guidelines in oncology","volume":"11","author":"Clark","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0021","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.eururo.2017.12.018","article-title":"Updates in the eighth edition of the tumor-node-metastasis staging classification for urologic cancers","volume":"73","author":"Paner","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0022","doi-asserted-by":"crossref","first-page":"51687","DOI":"10.18632\/oncotarget.10098","article-title":"Establishment and characterization of a penile cancer cell line, penl1, with a deleterious TP53 mutation as a paradigm of HPV-negative penile carcinogenesis","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0023","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/neuonc\/nou227","article-title":"PTK7 regulates Id1 expression in CD44-high glioma cells","volume":"17","author":"Liu","year":"2015","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0024","doi-asserted-by":"crossref","first-page":"14343","DOI":"10.18632\/oncotarget.11102","article-title":"Epithelial membrane protein 3 regulates TGF-\u03b2 signaling activation in CD44-high glioblastoma","volume":"8","author":"Jun","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11010-015-2382-6","article-title":"MiR-129-2 functions as a tumor suppressor in glioma cells by targeting HMGB1 and is down-regulated by DNA methylation","volume":"404","author":"Yang","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0026","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1476-4598-13-138","article-title":"Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells","volume":"13","author":"Li","year":"2014","journal-title":"Mol Cancer"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0027","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.2147\/OTT.S111291","article-title":"Silencing of miR-1247 by DNA methylation promoted non-small-cell lung cancer cell invasion and migration by effects of STMN1","volume":"9","author":"Zhang","year":"2016","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0028","doi-asserted-by":"crossref","first-page":"e2999","DOI":"10.1038\/cddis.2017.356","article-title":"miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt\/\u03b2-catenin signaling through targeting BCL9","volume":"8","author":"Yang","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0029","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.3390\/ijms13067271","article-title":"Oral administration of apigenin inhibits metastasis through AKT\/P70S6K1\/MMP-9 pathway in orthotopic ovarian tumor model","volume":"13","author":"He","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.3892\/or.2017.5926","article-title":"IL-33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-\u03baB pathway","volume":"38","author":"Zhang","year":"2017","journal-title":"Oncol Rep"},{"issue":"Aug (2)","key":"10.1016\/j.urolonc.2019.04.013_bib0031","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/bju.13379","article-title":"Clinical significance of preoperative C-reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma","volume":"118","author":"Li","year":"2016","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0032","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbrc.2014.11.093","article-title":"MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19","volume":"456","author":"Shan","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0033","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.humpath.2013.07.012","article-title":"The epidermal growth factor receptor is frequently overexpressed in penile squamous cell carcinomas: a tissue microarray and digital image analysis study of 112 cases","volume":"44","author":"Chaux","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0034","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaad.2012.12.973","article-title":"Two major pathways of penile carcinogenesis: HPV-induced penile cancers overexpress p16ink4a, HPV-negative cancers associated with dermatoses express p53, but lack p16ink4a overexpression","volume":"69","author":"Mannweiler","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0035","doi-asserted-by":"crossref","first-page":"e17517","DOI":"10.1371\/journal.pone.0017517","article-title":"Alternative HER\/PTEN\/Akt pathway activation in HPV positive and negative penile carcinomas","volume":"6","author":"Stankiewicz","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0036","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cytogfr.2014.12.001","article-title":"IGFBP-2: the dark horse in metabolism and cancer","volume":"26","author":"Russo","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0037","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12079-015-0261-2","article-title":"IGFBP-2 \u2013 taking the lead in growth, metabolism and cancer","volume":"9","author":"Yau","year":"2015","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0038","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1215\/15228517-2008-114","article-title":"Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas","volume":"11","author":"Lin","year":"2009","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0039","first-page":"1031","article-title":"Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients","volume":"76","author":"Cohen","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0040","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/hpb.12199","article-title":"Serum IGFBP2 and MSLN as diagnostic and prognostic biomarkers for pancreatic cancer","volume":"16","author":"Kendrick","year":"2014","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0041","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2133.2007.08305.x","article-title":"Human papillomavirus-associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma","volume":"158","author":"Prowse","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.urolonc.2019.04.013_bib0042","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.18632\/oncotarget.24688","article-title":"Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway","volume":"9","author":"Adimonye","year":"2018","journal-title":"Oncotarget"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143919301462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143919301462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:15:21Z","timestamp":1761041721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143919301462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1078143919301462"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2019.04.013","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preoperative plasma IGFBP2 is associated with nodal metastasis in patients with penile squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2019.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}