{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:13:13Z","timestamp":1773699193783,"version":"3.50.1"},"reference-count":114,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.urolonc.2020.01.015","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T20:15:27Z","timestamp":1582143327000},"page":"315-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Prognostic value of preoperative blood-based biomarkers in upper tract urothelial carcinoma treated with nephroureterectomy: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-6569","authenticated-orcid":false,"given":"Keiichiro","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-0482","authenticated-orcid":false,"given":"Florian","family":"Janisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Mostafaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Lysenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7194-5982","authenticated-orcid":false,"given":"Shoji","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Egawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2020.01.015_bib0001","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.eururo.2017.07.036","article-title":"European Association of Urology Guidelines on upper urinary tract urothelial carcinoma: 2017 update","volume":"73","author":"Roupret","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0002","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00345-016-1928-x","article-title":"Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)","volume":"35","author":"Soria","year":"2017","journal-title":"World J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0003","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.eururo.2014.08.003","article-title":"Conditional survival after radical nephroureterectomy for upper tract carcinoma","volume":"67","author":"Ploussard","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0004","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.eururo.2011.09.017","article-title":"The impact of tumor multifocality on outcomes in patients treated with radical nephroureterectomy","volume":"61","author":"Chromecki","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1464-410X.2011.10288.x","article-title":"Combining imaging and ureteroscopy variables in a preoperative multivariable model for prediction of muscle-invasive and non-organ confined disease in patients with upper tract urothelial carcinoma","volume":"109","author":"Favaretto","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0006","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1464-410X.2008.08003.x","article-title":"Tumour architecture is an independent predictor of outcomes after nephroureterectomy: a multi-institutional analysis of 1363 patients","volume":"103","author":"Remzi","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0007","doi-asserted-by":"crossref","first-page":"720","DOI":"10.21037\/tau.2016.09.07","article-title":"Predictive models and prognostic factors for upper tract urothelial carcinoma: a comprehensive review of the literature","volume":"5","author":"Mbeutcha","year":"2016","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0008","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.eururo.2014.11.035","article-title":"A systematic review and meta-analysis of clinicopathologic factors linked to intravesical recurrence after radical nephroureterectomy to treat upper tract urothelial carcinoma","volume":"67","author":"Seisen","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0009","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.eururo.2012.04.052","article-title":"Impact of distal ureter management on oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma","volume":"65","author":"Xylinas","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0010","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.eururo.2010.07.003","article-title":"The effect of tumor location on prognosis in patients treated with radical nephroureterectomy at Memorial Sloan-Kettering Cancer Center","volume":"58","author":"Favaretto","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0011","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.urology.2009.07.1296","article-title":"A critical appraisal of the value of lymph node dissection at nephroureterectomy for upper tract urothelial carcinoma","volume":"75","author":"Lughezzani","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0012","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.juro.2012.10.057","article-title":"Prediction of cancer specific survival after radical nephroureterectomy for upper tract urothelial carcinoma: development of an optimized postoperative nomogram using decision curve analysis","volume":"189","author":"Roupret","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0013","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0090-4295(00)00800-1","article-title":"Limitations of computed tomography in the preoperative staging of upper tract urothelial carcinoma","volume":"56","author":"Scolieri","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0014","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/iju.12587","article-title":"Role of diffusion-weighted magnetic resonance imaging as an imaging biomarker of urothelial carcinoma","volume":"21","author":"Yoshida","year":"2014","journal-title":"Int J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0015","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.eururo.2011.07.009","article-title":"Lymphadenectomy at the time of nephroureterectomy for upper tract urothelial cancer","volume":"60","author":"Roscigno","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0016","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3892\/mco.2015.553","article-title":"Preoperative C-reactive protein as a prognostic predictor for upper tract urothelial carcinoma: a systematic review and meta-analysis","volume":"3","author":"Luo","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0017","first-page":"8094","article-title":"Systemic inflammatory responses predict survival outcomes and male gender predicts metachronous bladder cancer of upper tract urothelial carcinoma","volume":"10","author":"Jiang","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0018","first-page":"547","article-title":"Chronic kidney disease and positive surgical margins as prognosticators for upper urinary tract urothelial carcinoma patients undergoing radical nephroureterectomy","volume":"10","author":"Kuroda","year":"2019","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0019","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijsu.2019.03.022","article-title":"Clinicopathological and prognostic significance of preoperative plasma fibrinogen level in patients with upper urinary tract urothelial carcinoma: a retrospective tumor marker prognostic study","volume":"65","author":"Liu","year":"2019","journal-title":"Int J Surg"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0020","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.juro.2013.09.010","article-title":"Impact of preoperative anemia on oncologic outcomes of upper tract urothelial carcinoma treated with radical nephroureterectomy","volume":"191","author":"Rink","year":"2014","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0022","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0023","first-page":"1","article-title":"Evaluating non-randomised intervention studies","volume":"7","author":"Deeks","year":"2003","journal-title":"Health Technol Assess (Winchester, England)"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0024","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0009-8981(57)90027-X","article-title":"An enzymic test for the diagnosis of viral hepatitis; the transaminase serum activities","volume":"2","author":"De Ritis","year":"1957","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0025","doi-asserted-by":"crossref","first-page":"d2090","DOI":"10.1136\/bmj.d2090","article-title":"How to obtain the confidence interval from a P value","volume":"343","author":"Altman","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0026","doi-asserted-by":"crossref","first-page":"d2304","DOI":"10.1136\/bmj.d2304","article-title":"How to obtain the P value from a confidence interval","volume":"343","author":"Altman","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0027","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cct.2006.04.004","article-title":"Random-effects model for meta-analysis of clinical trials: an update","volume":"28","author":"DerSimonian","year":"2007","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0029","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0030","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/1536867X0400400204","article-title":"Funnel plots in meta-analysis","volume":"4","author":"Sterne","year":"2004","journal-title":"Stata J"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0031","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000362248","article-title":"Preoperative C-reactive protein in the serum: a prognostic biomarker for upper urinary tract urothelial carcinoma treated with radical nephroureterectomy","volume":"93","author":"Aziz","year":"2014","journal-title":"Urol Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0032","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.clgc.2013.04.003","article-title":"Preoperative neutrophil-lymphocyte ratio as an independent prognostic marker for patients with upper urinary tract urothelial carcinoma","volume":"11","author":"Azuma","year":"2013","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0033","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1245\/s10434-015-4781-z","article-title":"The prognostic significance of inflammation-associated blood cell markers in patients with upper tract urothelial carcinoma","volume":"23","author":"Cheng","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0034","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s11255-017-1613-z","article-title":"The De Ritis (aspartate transaminase\/alanine transaminase) ratio as a predictor of oncological outcomes in patients after surgery for upper urinary tract urothelial carcinoma","volume":"49","author":"Cho","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0035","doi-asserted-by":"crossref","first-page":"e394","DOI":"10.1016\/j.clgc.2018.11.015","article-title":"Effects of variant histology on the oncologic outcomes of patients with upper urinary tract carcinoma after radical nephroureterectomy: a propensity score-matched analysis","volume":"17","author":"Chung","year":"2019","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0036","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/bju.12441","article-title":"Validation of pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma","volume":"114","author":"Dalpiaz","year":"2014","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0037","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000452109","article-title":"Validation of the preoperative platelet-to-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma","volume":"98","author":"Dalpiaz","year":"2017","journal-title":"Urol Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0038","first-page":"1435","article-title":"Postoperative nomogram for disease recurrence and cancer-specific death for upper tract urothelial carcinoma: comparison to American Joint Committee on Cancer staging classification","volume":"11","author":"Ehdaie","year":"2014","journal-title":"Urol J"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0039","doi-asserted-by":"crossref","first-page":"e1039","DOI":"10.1016\/j.clgc.2017.06.003","article-title":"Predictive and prognostic value of preoperative thrombocytosis in upper tract urothelial carcinoma","volume":"15","author":"Foerster","year":"2017","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0040","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/iju.12868","article-title":"Role of adjuvant chemotherapy for lymph node-positive upper tract urothelial carcinoma and the prognostic significance of C-reactive protein: a multi-institutional, retrospective study","volume":"22","author":"Fujita","year":"2015","journal-title":"Int J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0041","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s10147-014-0695-1","article-title":"Preoperative risk stratification for cancer-specific survival of patients with upper urinary tract urothelial carcinoma treated by nephroureterectomy","volume":"20","author":"Fujita","year":"2015","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0042","first-page":"8464","article-title":"Preoperative AST\/ALT ratio predicts long-term survival after radical nephroureterectomy in patients with upper tract urothelial carcinoma","volume":"10","author":"Gao","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0043","doi-asserted-by":"crossref","first-page":"38175","DOI":"10.1038\/srep38175","article-title":"Adjuvant radiotherapy for locally advanced upper tract urothelial carcinoma","volume":"6","author":"Huang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0044","doi-asserted-by":"crossref","first-page":"36772","DOI":"10.18632\/oncotarget.13694","article-title":"Preoperative serum pre-albumin as an independent prognostic indicator in patients with localized upper tract urothelial carcinoma after radical nephroureterectomy","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0045","doi-asserted-by":"crossref","first-page":"36761","DOI":"10.18632\/oncotarget.13611","article-title":"Prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (F-PLR) in patients with localized upper tract urothelial carcinoma","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.urolonc.2017.04.012","article-title":"Preoperative controlling nutritional status (CONUT) score as a novel predictive biomarker of survival in patients with localized urothelial carcinoma of the upper urinary tract treated with radical nephroureterectomy","volume":"35","author":"Ishihara","year":"2017","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0047","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1245\/s10434-018-6942-3","article-title":"Combination of the preoperative systemic immune-inflammation index and monocyte-lymphocyte ratio as a novel prognostic factor in patients with upper-tract urothelial carcinoma","volume":"26","author":"Jan","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0048","doi-asserted-by":"crossref","first-page":"e633","DOI":"10.1016\/j.clgc.2017.01.003","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio-based markers during pre- and postadjuvant chemotherapy in patients with advanced urothelial carcinoma of upper urinary tract","volume":"15","author":"Kang","year":"2017","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0049","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00345-015-1484-9","article-title":"Prognostic value of systemic inflammatory responses in patients with upper urinary tract urothelial carcinoma","volume":"33","author":"Kim","year":"2015","journal-title":"World J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0050","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/jjco\/hyy084","article-title":"Preoperative risk classification using neutrophil-lymphocyte ratio and hydronephrosis for upper tract urothelial carcinoma","volume":"48","author":"Kohada","year":"2018","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0051","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1590\/S1677-5538.IBJU.2014.06.06","article-title":"Preoperative serum albumin as a prognostic factor in patients with upper urinary tract urothelial carcinoma","volume":"40","author":"Ku","year":"2014","journal-title":"Int Braz J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0052","doi-asserted-by":"crossref","first-page":"e379","DOI":"10.1016\/j.clgc.2016.08.023","article-title":"De Ritis ratio (AST\/ALT) as a significant prognostic factor in patients with upper tract urothelial cancer treated with surgery","volume":"15","author":"Lee","year":"2017","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0053","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.eururo.2006.11.021","article-title":"Transitional cell carcinoma of the ureter: prognostic factors influencing progression and survival","volume":"51","author":"Lehmann","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0054","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cca.2019.02.007","article-title":"Predictive value of preoperative lymphocyte-to-monocyte ratio for patients with upper tract urothelial carcinoma","volume":"492","author":"Li","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0055","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.2147\/OTT.S193771","article-title":"High aspartate transaminase\/alanine transaminase ratio predicts poor prognosis in patients with localized upper tract urothelial cancer: a propensity score-matched study in a large Chinese center","volume":"12","author":"Li","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0056","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11255-012-0347-1","article-title":"Preoperative prognostic factors after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma","volume":"45","author":"Morizane","year":"2013","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0057","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s11255-015-1033-x","article-title":"Risk stratification model, including preoperative serum C-reactive protein and estimated glomerular filtration rate levels, in patients with upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy","volume":"47","author":"Morizane","year":"2015","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0058","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.urolonc.2012.05.008","article-title":"C-reactive protein: a biomarker of survival in patients with localized upper tract urothelial carcinoma treated with radical nephroureterectomy","volume":"31","author":"Obata","year":"2013","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0059","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/iju.13767","article-title":"Prognostic role of the preoperative serum albumin: globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma","volume":"25","author":"Otsuka","year":"2018","journal-title":"Int J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0060","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.juro.2013.10.073","article-title":"Validation of the preoperative plasma fibrinogen level as a prognostic factor in a European cohort of patients with localized upper tract urothelial carcinoma","volume":"191","author":"Pichler","year":"2014","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0061","article-title":"High rates of advanced disease, complications, and decline of renal function after radical nephroureterectomy","volume":"32","author":"Raman","year":"2014","journal-title":"Urol Oncol Semin Orig Investig"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0062","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.clgc.2015.10.003","article-title":"Impact of perioperative allogenic blood transfusion on survival after radical nephroureterectomy for upper tract urothelial carcinoma","volume":"14","author":"Rink","year":"2016","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0063","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1464-410X.2007.06934.x","article-title":"The impact of preoperative serum C-reactive protein on the prognosis of patients with upper urinary tract urothelial carcinoma treated surgically","volume":"100","author":"Saito","year":"2007","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0064","first-page":"4389","article-title":"Risk group stratification based on preoperative factors to predict survival after nephroureterectomy in patients with upper urinary tract urothelial carcinoma","volume":"20","author":"Sakano","year":"2013","journal-title":"AnnSurg Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0065","first-page":"300","article-title":"Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma: a large, multicenter cohort analysis","volume":"70","author":"Son","year":"2018","journal-title":"Minerva Urol Nefrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0066","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2407-13-101","article-title":"Preoperative serum C-reactive protein: a prognostic marker in patients with upper urinary tract urothelial carcinoma","volume":"13","author":"Stein","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0067","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3892\/ol.2013.1485","volume":"6","author":"Takahara","year":"2013","journal-title":"Oncol Lett"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0068","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1002\/cam4.1751","article-title":"Is preoperative serum lactate dehydrogenase useful in predicting the outcomes of patients with upper tract urothelial carcinoma?","volume":"7","author":"Tan","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0069","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/aja.aja_84_18","article-title":"The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma","volume":"21","author":"Tan","year":"2019","journal-title":"Asian J Androl"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0070","doi-asserted-by":"crossref","first-page":"12311","DOI":"10.1038\/s41598-018-29833-5","article-title":"The prognostic significance of a lbumin-to- a lkaline phosphatase ratio in upper tract urothelial carcinoma","volume":"8","author":"Tan","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0071","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.euf.2015.02.001","article-title":"Impact of combined use of blood-based inflammatory markers on patients with upper tract urothelial carcinoma following radical nephroureterectomy: proposal of a cumulative marker score as a novel predictive tool for prognosis","volume":"1","author":"Tanaka","year":"2015","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0072","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00345-016-1848-9","article-title":"Promising role of preoperative neutrophil-to-lymphocyte ratio in patients treated with radical nephroureterectomy","volume":"35","author":"Vartolomei","year":"2017","journal-title":"World J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0073","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/j.clgc.2016.02.009","article-title":"Prognostic value of gene methylation and clinical factors in non-muscle-invasive upper tract urothelial carcinoma after radical nephroureterectomy","volume":"14","author":"Xing","year":"2016","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0074","article-title":"Pretreatment elevated fibrinogen level predicts worse oncologic outcomes in upper tract urothelial carcinoma","author":"Xu","year":"2019","journal-title":"Asian J Androl"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.urolonc.2016.03.018","article-title":"Is preoperative anemia a risk factor for upper tract urothelial carcinoma following radical nephroureterectomy","volume":"34","author":"Yeh","year":"2016","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0076","doi-asserted-by":"crossref","first-page":"e0139624","DOI":"10.1371\/journal.pone.0139624","article-title":"Concurrent preoperative presence of hydronephrosis and flank pain independently predicts worse outcome of upper tract urothelial carcinoma","volume":"10","author":"Yeh","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0077","doi-asserted-by":"crossref","first-page":"66540","DOI":"10.18632\/oncotarget.16239","article-title":"Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0078","doi-asserted-by":"crossref","first-page":"290.e17","DOI":"10.1016\/j.urolonc.2018.12.027","article-title":"Development and external validation of a nomogram predicting prognosis of upper tract urothelial carcinoma after radical nephroureterectomy","volume":"37","author":"Zeng","year":"2019","journal-title":"Urol Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0079","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s11255-016-1401-1","article-title":"Pretreatment serum pseudocholinesterase level as a novel prognostic biomarker for upper tract urothelial carcinoma","volume":"48","author":"Zhang","year":"2016","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0080","article-title":"Preoperative plasma fibrinogen level represents an independent prognostic factor in a Chinese cohort of patients with upper tract urothelial carcinoma","volume":"11","author":"Zhang","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0081","doi-asserted-by":"crossref","first-page":"e0144961","DOI":"10.1371\/journal.pone.0144961","article-title":"Prognostic significance of preoperative albumin-globulin ratio in patients with upper tract urothelial carcinoma","volume":"10","author":"Zhang","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0082","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0022-5347(05)65348-7","article-title":"Preoperative plasma levels of interleukin-6 and its soluble receptor predict disease recurrence and survival of patients with bladder cancer","volume":"167","author":"Andrews","year":"2002","journal-title":"J Urol"},{"issue":"Suppl 1","key":"10.1016\/j.urolonc.2020.01.015_bib0083","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/0284186X.2010.542174","article-title":"Tumor markers in prostate cancer I: blood-based markers","volume":"50","author":"Shariat","year":"2011","journal-title":"Acta Oncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0084","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1158\/0008-5472.CAN-11-1154","article-title":"Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression","volume":"71","author":"Putluri","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0085","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/01.ju.0000080401.85145.ee","article-title":"Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder","volume":"170","author":"Shariat","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0086","doi-asserted-by":"crossref","DOI":"10.1097\/JU.0000000000000279","article-title":"Association between inflammatory potential of diet and bladder cancer risk: results of three United States prospective cohort studies","author":"Abufaraj","year":"2019","journal-title":"J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0087","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00345-018-2235-5","article-title":"Is neutrophil-to-lymphocytes ratio a clinical relevant preoperative biomarker in upper tract urothelial carcinoma? A meta-analysis of 4385 patients","volume":"36","author":"Vartolomei","year":"2018","journal-title":"World J Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0088","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.urology.2016.06.007","article-title":"Development of a preoperative nomogram incorporating biomarkers of systemic inflammatory response to predict nonorgan-confined urothelial carcinoma of the bladder at radical cystectomy","volume":"95","author":"Lucca","year":"2016","journal-title":"Urology"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0089","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1385\/MO:18:4:243","article-title":"Treatment resistance of solid tumors: role of hypoxia and anemia","volume":"18","author":"Vaupel","year":"2001","journal-title":"Med Oncol"},{"issue":"Suppl 5","key":"10.1016\/j.urolonc.2020.01.015_bib0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1634\/theoncologist.9-90005-10","article-title":"The role of hypoxia-induced factors in tumor progression","volume":"9","author":"Vaupel","year":"2004","journal-title":"Oncologist"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0091","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0959-8049(00)00159-3","article-title":"Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation","volume":"36","author":"Dachs","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0092","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10409230091169186","article-title":"Hypoxia, clonal selection, and the role of HIF-1 in tumor progression","volume":"35","author":"Semenza","year":"2000","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0093","first-page":"4846","article-title":"Prognostic significance of hypoxia inducible factor-1alpha expression in patients with clear cell renal cell carcinoma","volume":"17","author":"Wu","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0094","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0006-2952(02)01168-1","article-title":"Signal transduction to hypoxia-inducible factor 1","volume":"64","author":"Semenza","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0095","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1097-2765(00)80137-9","article-title":"A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs","volume":"2","author":"Coquelle","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0096","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/cncr.22557","article-title":"Renal diagnosis of chronic hemodialysis patients with urinary tract transitional cell carcinoma in Taiwan","volume":"109","author":"Chang","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0097","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000020106","article-title":"Transitional cell carcinoma in dialysis patients","volume":"37","author":"Ou","year":"2000","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0098","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2215\/CJN.00950208","article-title":"Aspects of immune dysfunction in end-stage renal disease","volume":"3","author":"Kato","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0099","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000013314","article-title":"Cancer in end-stage renal disease: potential factors involved -editorial","volume":"18","author":"Vamvakas","year":"1998","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0100","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0272-6386(99)70069-7","article-title":"Increased genomic damage in lymphocytes of patients before and after long-term maintenance hemodialysis therapy","volume":"34","author":"Stopper","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0101","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.ki.5002042","article-title":"Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study","volume":"71","author":"Keller","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0102","first-page":"406","article-title":"Comparative effectiveness of cisplatin-based and carboplatin-based chemotherapy for treatment of advanced urothelial carcinoma","volume":"23","author":"Galsky","year":"2012","journal-title":"AnnOncol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0103","first-page":"117","article-title":"The De Ritis ratio: the test of time","volume":"34","author":"Botros","year":"2013","journal-title":"Clin Biochem Rev"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0104","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.yexcr.2015.04.007","article-title":"The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism","volume":"335","author":"Conde","year":"2015","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0106","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1022454932269","article-title":"Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance","volume":"29","author":"Dorward","year":"1997","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0107","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","article-title":"Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance","volume":"9","author":"Fantin","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0108","first-page":"1392","article-title":"Occurrence of the malate-aspartate shuttle in various tumor types","volume":"36","author":"Greenhouse","year":"1976","journal-title":"Cancer Res"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0109","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/dmrr.2614","article-title":"Diabetes mellitus with poor glycemic control increases bladder cancer recurrence risk in patients with upper urinary tract urothelial carcinoma","volume":"31","author":"Tai","year":"2015","journal-title":"Diab Metab Res Rev"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0110","first-page":"77","article-title":"Comparison of glucose-consumption and thymidine-incorporation endpoints in histocultured human superficial bladder tumors","volume":"14","author":"Chang","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0111","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yexcr.2016.01.005","article-title":"Metabolic alterations in bladder cancer: applications for cancer imaging","volume":"341","author":"Whyard","year":"2016","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0112","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ejrad.2015.12.017","article-title":"FDG-PET\/CT as a post-treatment restaging tool in urothelial carcinoma: comparison with contrast-enhanced CT","volume":"85","author":"Kitajima","year":"2016","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0113","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1464-410X.2009.08838.x","article-title":"Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract","volume":"104","author":"Colin","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.urolonc.2020.01.015_bib0114","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1073\/pnas.1119920109","article-title":"Aristolochic acid-associated urothelial cancer in Taiwan","volume":"109","author":"Chen","year":"2012","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143920300351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143920300351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:19:12Z","timestamp":1761041952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143920300351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":114,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1078143920300351"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2020.01.015","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of preoperative blood-based biomarkers in upper tract urothelial carcinoma treated with nephroureterectomy: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2020.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}