{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:15Z","timestamp":1777417215912,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572523"],"award-info":[{"award-number":["81572523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700665"],"award-info":[{"award-number":["81700665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873626"],"award-info":[{"award-number":["81873626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902592"],"award-info":[{"award-number":["81902592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province Funds for Distinguished Young Scientists of China","award":["2016JJ1026"],"award-info":[{"award-number":["2016JJ1026"]}]},{"name":"Hunan Province Key R&D Program","award":["2019SK2202"],"award-info":[{"award-number":["2019SK2202"]}]},{"name":"Xiangya Hospital Youth Fund","award":["2018Q09"],"award-info":[{"award-number":["2018Q09"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.urolonc.2020.04.015","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:49:33Z","timestamp":1588837773000},"page":"641.e19-641.e29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["A nomogram incorporating PD-L1, NLR, and clinicopathologic features to predict inguinal lymph node metastasis in penile squamous cell carcinoma"],"prefix":"10.1016","volume":"38","author":[{"given":"Jiao","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongchen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbiao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongbing","family":"Zu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.urolonc.2020.04.015_bib0001","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.eururo.2008.04.094","article-title":"Anatomical mapping of lymphatic drainage in penile carcinoma with SPECT-CT: implications for the extent of inguinal lymph node dissection","volume":"54","author":"Leijte","year":"2008","journal-title":"Eur Urol"},{"issue":"3","key":"10.1016\/j.urolonc.2020.04.015_bib0002","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/01.ju.0000154565.37397.4d","article-title":"Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases","volume":"173","author":"Kroon","year":"2005","journal-title":"J Urol"},{"issue":"5","key":"10.1016\/j.urolonc.2020.04.015_bib0003","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.eururo.2010.08.015","article-title":"Prognostic factors for occult inguinal lymph node involvement in penile carcinoma and assessment of the high-risk EAU subgroup: a two-institution analysis of 342 clinically node-negative patients","volume":"58","author":"Graafland","year":"2010","journal-title":"Eur Urol"},{"issue":"3","key":"10.1016\/j.urolonc.2020.04.015_bib0004","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1464-410X.2006.06296.x","article-title":"A prospective study of 100 cases of penile cancer managed according to European Association of Urology guidelines","volume":"98","author":"Hegarty","year":"2006","journal-title":"BJU Int"},{"issue":"7","key":"10.1016\/j.urolonc.2020.04.015_bib0005","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/PAS.0b013e3181641365","article-title":"Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm","volume":"32","author":"Velazquez","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.urolonc.2020.04.015_bib0006","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.juro.2010.03.145","article-title":"Development and evaluation of a nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes","volume":"184","author":"Zhu","year":"2010","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.urolonc.2020.04.015_bib0007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00345-009-0421-1","article-title":"Factors predicting inguinal node metastasis in squamous cell cancer of penis","volume":"28","author":"Bhagat","year":"2010","journal-title":"World J Urol"},{"issue":"6","key":"10.1016\/j.urolonc.2020.04.015_bib0008","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/bju.14652","article-title":"A National Cancer Database-based nomogram to predict lymph node metastasis in penile cancer","volume":"123","author":"Peak","year":"2019","journal-title":"BJU Int"},{"issue":"5","key":"10.1016\/j.urolonc.2020.04.015_bib0009","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0022-5347(05)01003-7","article-title":"Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis","volume":"175","author":"Ficarra","year":"2006","journal-title":"J Urol"},{"issue":"12","key":"10.1016\/j.urolonc.2020.04.015_bib0010","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1111\/j.1464-410X.2009.08362.x","article-title":"Interobserver variation in grading and staging of squamous cell carcinoma of the penis in relation to the clinical outcome","volume":"103","author":"Naumann","year":"2009","journal-title":"BJU Int"},{"issue":"328","key":"10.1016\/j.urolonc.2020.04.015_bib0011","doi-asserted-by":"crossref","first-page":"328rv4","DOI":"10.1126\/scitranslmed.aad7118","article-title":"PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations","volume":"8","author":"Zou","year":"2016","journal-title":"Sci Transl Med"},{"issue":"12","key":"10.1016\/j.urolonc.2020.04.015_bib0012","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41585-018-0083-0","article-title":"Immunotherapy for advanced penile cancer\u2014rationale and potential","volume":"15","author":"McGregor","year":"2018","journal-title":"Nat Rev Urol"},{"issue":"10","key":"10.1016\/j.urolonc.2020.04.015_bib0013","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ctrv.2015.11.001","article-title":"Predictive biomarkers in PD-1\/PD-L1 checkpoint blockade immunotherapy","volume":"41","author":"Meng","year":"2015","journal-title":"Cancer Treat Rev"},{"issue":"9","key":"10.1016\/j.urolonc.2020.04.015_bib0014","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/annonc\/mdw216","article-title":"Frequent PD-L1 expression in primary and metastatic penile squamous cell carcinoma: potential opportunities for immunotherapeutic approaches","volume":"27","author":"Udager","year":"2016","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.urolonc.2020.04.015_bib0015","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1269047","article-title":"Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma","volume":"6","author":"Deng","year":"2017","journal-title":"Oncoimmunology"},{"issue":"6","key":"10.1016\/j.urolonc.2020.04.015_bib0016","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.urolonc.2020.04.015_bib0017","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.semcancer.2013.02.005","article-title":"Modulation of neutrophil granulocytes in the tumor microenvironment: mechanisms and consequences for tumor progression","volume":"23","author":"Dumitru","year":"2013","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"10.1016\/j.urolonc.2020.04.015_bib0018","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.smim.2016.03.018","article-title":"Human neutrophils: their role in cancer and relation to myeloid-derived suppressor cells","volume":"28","author":"Moses","year":"2016","journal-title":"Semin Immunol"},{"key":"10.1016\/j.urolonc.2020.04.015_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2017.05.005","article-title":"Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: a systematic review and meta-analysis of 66 cohort studies","volume":"58","author":"Mei","year":"2017","journal-title":"Cancer Treat Rev"},{"issue":"undefined","key":"10.1016\/j.urolonc.2020.04.015_bib0020","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12885-016-2443-6","article-title":"Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer","volume":"16","author":"Kasuga","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.urolonc.2020.04.015_bib0021","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.euf.2018.06.008","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in penile squamous cell carcinoma patients undergoing inguinal lymph node dissection","volume":"5","author":"Azizi","year":"2019","journal-title":"Eur Urol Focus"},{"issue":"6","key":"10.1016\/j.urolonc.2020.04.015_bib0022","first-page":"1671","article-title":"Programmed death-ligand 1 (PD-L1) expression associated with a high neutrophil\/lymphocyte ratio in cholangiocarcinoma","volume":"18","author":"Sangkhamanon","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"10.1016\/j.urolonc.2020.04.015_bib0023","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11255-015-1182-y","article-title":"Saphenous vein sparing during laparoscopic bilateral inguinal lymphadenectomy for penile carcinoma patients","volume":"48","author":"Cui","year":"2016","journal-title":"Int Urol Nephrol"},{"issue":"4","key":"10.1016\/j.urolonc.2020.04.015_bib0024","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.eururo.2017.12.018","article-title":"Updates in the eighth edition of the tumor-node-metastasis staging classification for urologic cancers","volume":"73","author":"Paner","year":"2018","journal-title":"Eur Urol"},{"issue":"10","key":"10.1016\/j.urolonc.2020.04.015_bib0025","first-page":"5419","article-title":"Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody","volume":"46","author":"Budwit-Novotny","year":"1986","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.urolonc.2020.04.015_bib0026","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/bimj.200410135","article-title":"Estimation of the Youden Index and its associated cutoff point","volume":"47","author":"Fluss","year":"2005","journal-title":"Biom J"},{"issue":"1","key":"10.1016\/j.urolonc.2020.04.015_bib0027","doi-asserted-by":"crossref","DOI":"10.1515\/ijb-2018-0060","article-title":"The Youden index in the generalized receiver operating characteristic curve context","volume":"15","author":"Martinez-Camblor","year":"2019","journal-title":"Int J Biostat"},{"issue":"2","key":"10.1016\/j.urolonc.2020.04.015_bib0028","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/bju.13379","article-title":"Clinical significance of preoperative C-reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma","volume":"118","author":"Li","year":"2016","journal-title":"BJU Int"},{"issue":"4","key":"10.1016\/j.urolonc.2020.04.015_bib0029","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.clgc.2015.12.019","article-title":"Clinical significance of p53 and p16(ink4a) status in a contemporary North American penile carcinoma cohort","volume":"14","author":"Zargar-Shoshtari","year":"2016","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.urolonc.2020.04.015_bib0030","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.2147\/CMAR.S206579","article-title":"Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies","volume":"11","author":"Hu","year":"2019","journal-title":"Cancer Manag Res"},{"issue":"1","key":"10.1016\/j.urolonc.2020.04.015_bib0031","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-017-0424-2","article-title":"Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden","volume":"9","author":"Chalmers","year":"2017","journal-title":"Genome Med"},{"issue":"3","key":"10.1016\/j.urolonc.2020.04.015_bib0032","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41568-019-0116-x","article-title":"The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy","volume":"19","author":"Havel","year":"2019","journal-title":"Nat Rev Cancer"},{"issue":"2-3","key":"10.1016\/j.urolonc.2020.04.015_bib0033","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000495251","article-title":"No evidence of microsatellite instability and loss of mismatch-repair-protein expression in squamous cell carcinoma of the penis","volume":"86","author":"Stoehr","year":"2019","journal-title":"Pathobiology"},{"issue":"8","key":"10.1016\/j.urolonc.2020.04.015_bib0034","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm730","article-title":"Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion","volume":"8","author":"Dong","year":"2002","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.urolonc.2020.04.015_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2018.09.035","article-title":"A paradigm shift in cancer immunotherapy: from enhancement to normalization","volume":"175","author":"Sanmamed","year":"2018","journal-title":"Cell"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143920301423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143920301423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:18:04Z","timestamp":1761041884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143920301423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1078143920301423"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2020.04.015","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A nomogram incorporating PD-L1, NLR, and clinicopathologic features to predict inguinal lymph node metastasis in penile squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2020.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}