{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:10:25Z","timestamp":1780549825007,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.urolonc.2021.12.014","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T06:27:05Z","timestamp":1641796025000},"page":"113.e9-113.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of pathogenic germline cancer risk variants in testicular cancer patients: Identifying high risk groups"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-9638","authenticated-orcid":false,"given":"Chethan","family":"Ramamurthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-9105","authenticated-orcid":false,"given":"Amin H.","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Abou Alaiwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Adib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie W.","family":"Akl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-3756","authenticated-orcid":false,"given":"Edward D.","family":"Esplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-1026","authenticated-orcid":false,"given":"Michael A.","family":"Liss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2579-1833","authenticated-orcid":false,"given":"Gail E.","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-9611","authenticated-orcid":false,"given":"Guru P.","family":"Sonpavde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2021.12.014_bib0001","doi-asserted-by":"crossref","first-page":"13889","DOI":"10.1038\/srep13889","article-title":"Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches","volume":"5","author":"Litchfield","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.urolonc.2021.12.014_bib0002","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.eururo.2018.01.021","article-title":"Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) cases excludes major TGCT predisposition gene","volume":"73","author":"Litchfield","year":"2018","journal-title":"Eur Urol"},{"issue":"3","key":"10.1016\/j.urolonc.2021.12.014_bib0003","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.eururo.2018.05.036","article-title":"Large-scale analysis demonstrates familial testicular cancer to have polygenic aetiology","volume":"74","author":"Loveday","year":"2018","journal-title":"Eur Urol"},{"issue":"7","key":"10.1016\/j.urolonc.2021.12.014_bib0004","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ng.3896","article-title":"Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor","volume":"49","author":"Litchfield","year":"2017","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.urolonc.2021.12.014_bib0005","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1001\/jamaoncol.2018.6477","article-title":"Association of inherited pathogenic variants in checkpoint kinase 2 (CHEK2) with susceptibility to testicular germ cell tumors","volume":"5","author":"AlDubayan","year":"2019","journal-title":"JAMA Oncol"},{"issue":"7616","key":"10.1016\/j.urolonc.2021.12.014_bib0006","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.urolonc.2021.12.014_bib0007","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41436-019-0720-x","article-title":"Prevalence of pathogenic germline cancer risk variants in high-risk urothelial carcinoma","volume":"22","author":"Nassar","year":"2020","journal-title":"Genet Med"},{"issue":"7218","key":"10.1016\/j.urolonc.2021.12.014_bib0008","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature07517","article-title":"Accurate whole human genome sequencing using reversible terminator chemistry","volume":"456","author":"Bentley","year":"2008","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.urolonc.2021.12.014_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001091","article-title":"Modernizing reference genome assemblies","volume":"9","author":"Church","year":"2011","journal-title":"PLoS Biol"},{"issue":"9","key":"10.1016\/j.urolonc.2021.12.014_bib0010","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"issue":"5","key":"10.1016\/j.urolonc.2021.12.014_bib0011","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jmoldx.2015.04.009","article-title":"A systematic comparison of traditional and multigene panel testing for hereditary breast and ovarian cancer genes in more than 1000 patients","volume":"17","author":"Lincoln","year":"2015","journal-title":"J Mol Diagn"},{"issue":"5","key":"10.1016\/j.urolonc.2021.12.014_bib0012","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrg2958","article-title":"Genome structural variation discovery and genotyping","volume":"12","author":"Alkan","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.urolonc.2021.12.014_bib0013","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1471-2164-12-184","article-title":"Accurate and exact CNV identification from targeted high-throughput sequence data","volume":"12","author":"Nord","year":"2011","journal-title":"BMC Genomics"},{"issue":"19","key":"10.1016\/j.urolonc.2021.12.014_bib0014","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1200\/JCO.2013.53.6607","article-title":"Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment","volume":"32","author":"Kurian","year":"2014","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.urolonc.2021.12.014_bib0015","first-page":"1449","article-title":"Large genomic deletions and duplications in the BRCA1 gene identified by a novel quantitative method","volume":"63","author":"Hogervorst","year":"2003","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.urolonc.2021.12.014_bib0016","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/gim.2017.37","article-title":"Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria","volume":"19","author":"Nykamp","year":"2017","journal-title":"Genet Med"},{"issue":"1","key":"10.1016\/j.urolonc.2021.12.014_bib0017","doi-asserted-by":"crossref","first-page":"9","DOI":"10.6004\/jnccn.2017.0003","article-title":"NCCN Guidelines Insights: genetic\/familial high-risk assessment: breast and ovarian, version 2.2017","volume":"15","author":"Daly","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.urolonc.2021.12.014_bib0018","unstructured":"Huang KL, Mashl RJ, Wu Y, et al. Pathogenic germline variants in 10,389 adult cancers. Cell 2018;173(2):355\u201370.e14. https:\/\/doi.org\/10.1016\/j.cell.2018.03.039: [published Online First: Epub Date]."},{"issue":"11","key":"10.1016\/j.urolonc.2021.12.014_bib0019","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/jnci\/dji141","article-title":"Cancer risks and mortality in heterozygous ATM mutation carriers","volume":"97","author":"Thompson","year":"2005","journal-title":"J Natl Cancer Inst"},{"issue":"21","key":"10.1016\/j.urolonc.2021.12.014_bib0020","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1056\/NEJM198705213162101","article-title":"Breast and other cancers in families with ataxia-telangiectasia","volume":"316","author":"Swift","year":"1987","journal-title":"N Engl J Med"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143921005627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143921005627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:25:28Z","timestamp":1761042328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143921005627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1078143921005627"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2021.12.014","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of pathogenic germline cancer risk variants in testicular cancer patients: Identifying high risk groups","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2021.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}