{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:41:24Z","timestamp":1791312084396,"version":"4.3.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.urolonc.2025.09.001","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T01:59:21Z","timestamp":1759629561000},"page":"70.e1-70.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["IsoPSA density improves risk stratification and biopsy decision-making for clinically significant prostate cancer"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1926-2468","authenticated-orcid":false,"given":"Betty","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Benidir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Dortche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaeem","family":"Lone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Eltemamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Abouassaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Almassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyad","family":"Schwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Purysko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges-Pascal","family":"Haber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihad","family":"Kaouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Weight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp Tuna","family":"Beksac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.urolonc.2025.09.001_bib0001","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/JU.0000000000000185","article-title":"Clinical validation of IsoPSA\u2122, a single parameter, structure based assay for improved detection of high grade prostate cancer","volume":"201","author":"Stovsky","year":"2019","journal-title":"J Urol"},{"issue":"9","key":"10.1016\/j.urolonc.2025.09.001_bib0002","doi-asserted-by":"crossref","first-page":"408.e9","DOI":"10.1016\/j.urolonc.2022.06.002","article-title":"Clinical validation of IsoPSA, a single parameter, structure-focused assay for improved detection of prostate cancer: a prospective, multicenter study","volume":"40","author":"Klein","year":"2022","journal-title":"Urol Oncol"},{"issue":"6","key":"10.1016\/j.urolonc.2025.09.001_bib0003","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.eururo.2017.03.025","volume":"72","author":"Klein","year":"2017","journal-title":"Eur Urol"},{"issue":"2","key":"10.1016\/j.urolonc.2025.09.001_bib0004","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/UPJ.0000000000000291","article-title":"IsoPSA(\u00ae) reduces provider recommendations for biopsy and magnetic resonance imaging in men with total prostate specific antigen \u22654 ng\/ml: a real-world observational clinical utility study","volume":"9","author":"Scovell","year":"2022","journal-title":"Urol Pract"},{"key":"10.1016\/j.urolonc.2025.09.001_bib0005","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.urology.2022.05.029","article-title":"Elevated IsoPSA selects for clinically significant prostate cancer without a preference for any particular adverse histopathologic or radiographic feature","volume":"168","author":"Benidir","year":"2022","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.urolonc.2025.09.001_bib0006","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system","volume":"40","author":"Epstein","year":"2016","journal-title":"Am J Surg Pathol."},{"issue":"1","key":"10.1016\/j.urolonc.2025.09.001_bib0007","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.eururo.2015.08.038","article-title":"Synopsis of the PI-RADS v2 Guidelines for Multiparametric Prostate Magnetic resonance imaging and recommendations for use","volume":"69","author":"Barentsz","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.urolonc.2025.09.001_bib0008","first-page":"723","article-title":"Identifying risk factors for MRI-invisible prostate cancer in patients undergoing transperineal saturation biopsy","volume":"13","author":"Artiles Medina","year":"2021","journal-title":"Res Rep Urol"},{"key":"10.1016\/j.urolonc.2025.09.001_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejrad.2019.01.030","article-title":"Analysis of PI-RADS 4 cases: management recommendations for negatively biopsied patients","volume":"113","author":"Ullrich","year":"2019","journal-title":"Eur J Radiol"},{"issue":"9","key":"10.1016\/j.urolonc.2025.09.001_bib0010","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1464-410X.2004.05147.x","article-title":"Prostate cancers in the transition zone: part 2; clinical aspects","volume":"94","author":"Augustin","year":"2004","journal-title":"BJU Int"},{"issue":"1131","key":"10.1016\/j.urolonc.2025.09.001_bib0011","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20210916","article-title":"PI-RADS version 2.1 for the evaluation of transition zone lesions: a practical guide for radiologists","volume":"95","author":"Gaudiano","year":"2022","journal-title":"Br J Radiol"},{"key":"10.1016\/j.urolonc.2025.09.001_bib0012","first-page":"e767","article-title":"Lower rates of clinically-significant prostate cancer are present in PI-RADS 4 and 5 lesions in the transitional zone than peripheral zone","volume":"209","author":"Smith","year":"2023","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.urolonc.2025.09.001_bib0013","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1148\/radiol.2016152542","article-title":"Interobserver reproducibility of the PI-RADS version 2 lexicon: a multicenter study of six experienced prostate radiologists","volume":"280","author":"Rosenkrantz","year":"2016","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.urolonc.2025.09.001_bib0014","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2214\/AJR.20.24199","article-title":"PI-RADS versions 2 and 2.1: interobserver agreement and diagnostic performance in peripheral and transition zone lesions among six radiologists","volume":"217","author":"Bhayana","year":"2021","journal-title":"AJR Am J Roentgenol"},{"issue":"6_suppl","key":"10.1016\/j.urolonc.2025.09.001_bib0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1200\/JCO.2023.41.6_suppl.325","article-title":"The natural progression of patients with an IsoPSA value and its predictive ability of clinically significant prostate cancer on biopsy","volume":"41","author":"Abdallah","year":"2023","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.urolonc.2025.09.001_bib0016","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/pros.24886","article-title":"Prostate specific antigen density and clinically-significant Prostate cancer: the influence of prostatic volume","volume":"85","author":"Robinson","year":"2025","journal-title":"Prostate."},{"issue":"1","key":"10.1016\/j.urolonc.2025.09.001_bib0017","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1038\/s41598-024-57337-y","article-title":"PI-RADS v2.1 and PSAD for the prediction of clinically significant prostate cancer among patients with PSA levels of 4-10 ng\/ml","volume":"14","author":"Wen","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.urolonc.2025.09.001_bib0018","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/s12885-021-08216-6","article-title":"Is PSA density of the peripheral zone as a useful predictor for prostate cancer in patients with gray zone PSA levels?","volume":"21","author":"Lee","year":"2021","journal-title":"BMC Cancer"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143925003552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143925003552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:00:28Z","timestamp":1765285228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143925003552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1078143925003552"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2025.09.001","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IsoPSA density improves risk stratification and biopsy decision-making for clinically significant prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2025.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}