{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:26:39Z","timestamp":1773930399399,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Ataturk University","doi-asserted-by":"publisher","award":["TSA-2022-11436"],"award-info":[{"award-number":["TSA-2022-11436"]}],"id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.urolonc.2025.10.024","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:29:57Z","timestamp":1763634597000},"page":"125.e11-125.e22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging roles of vaspin and myonectin as novel biomarkers in prostate cancer diagnosis and staging vaspin and myonectin as novel biomarkers for prostate cancer"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-4800","authenticated-orcid":false,"given":"Saime","family":"Ozbek Sebin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-0889","authenticated-orcid":false,"given":"Y\u0131lmaz","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-815X","authenticated-orcid":false,"given":"Ahmet Emre","family":"Cinislioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7858-133X","authenticated-orcid":false,"given":"Ahmet Utku","family":"Kukus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-9849","authenticated-orcid":false,"given":"Basak","family":"Gulakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8754-0055","authenticated-orcid":false,"given":"Ahmet Selim","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-3564","authenticated-orcid":false,"given":"Esra","family":"Laloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2152-9361","authenticated-orcid":false,"given":"Mustafa","family":"Yagmur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.urolonc.2025.10.024_bib0001","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Collaborators","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.urolonc.2025.10.024_bib0002","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016\u201340 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.urolonc.2025.10.024_bib0003","first-page":"228","article-title":"The risk factors of prostate cancer and its prevention: a literature review","volume":"48","author":"Perdana","year":"2016","journal-title":"Acta Med Indones"},{"issue":"1","key":"10.1016\/j.urolonc.2025.10.024_bib0004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrurol.2017.167","article-title":"The inflammatory microenvironment and microbiome in prostate cancer development","volume":"15","author":"Sfanos","year":"2018","journal-title":"Nat Rev Urol"},{"issue":"6","key":"10.1016\/j.urolonc.2025.10.024_bib0005","article-title":"New insights into cell apoptosis and proliferation: the potential role of vaspin","volume":"72","author":"Pich","year":"2021","journal-title":"J Physiol Pharmacol"},{"issue":"10","key":"10.1016\/j.urolonc.2025.10.024_bib0006","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3390\/diagnostics10100801","article-title":"Effect of baseline characteristics and tumor burden on vaspin expression and progressive disease in operable colorectal cancer","volume":"10","author":"Kan","year":"2020","journal-title":"Diagnostics"},{"issue":"5","key":"10.1016\/j.urolonc.2025.10.024_bib0007","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/ERC-13-0280","article-title":"Evaluating vaspin and adiponectin in postmenopausal women with endometrial cancer","volume":"20","author":"Erdogan","year":"2013","journal-title":"Endocr Relat Cancer"},{"issue":"15","key":"10.1016\/j.urolonc.2025.10.024_bib0008","doi-asserted-by":"crossref","first-page":"11968","DOI":"10.1074\/jbc.M111.336834","article-title":"Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis","volume":"287","author":"Seldin","year":"2012","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.urolonc.2025.10.024_bib0009","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/CIRCRESAHA.118.313777","article-title":"Myonectin is an exercise-induced myokine that protects the heart from ischemia-reperfusion injury","volume":"123","author":"Otaka","year":"2018","journal-title":"Circ res"},{"issue":"13","key":"10.1016\/j.urolonc.2025.10.024_bib0010","article-title":"Up-to-date imaging and diagnostic techniques for prostate cancer: a literature review","volume":"13","author":"Zhu","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"6","key":"10.1016\/j.urolonc.2025.10.024_bib0011","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41571-020-0332-z","article-title":"All change in the prostate cancer diagnostic pathway","volume":"17","author":"Lomas","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"10.1016\/j.urolonc.2025.10.024_bib0012","article-title":"Diagnostic performance evaluation of multiparametric magnetic resonance imaging in the detection of prostate cancer with supervised machine learning methods","volume":"13","author":"Nematollahi","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"17","key":"10.1016\/j.urolonc.2025.10.024_bib0013","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1002\/cncr.32176","article-title":"Metastatic prostate cancer at diagnosis and through progression in the prostate, lung, colorectal, and ovarian cancer screening trial","volume":"125","author":"Pinsky","year":"2019","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.urolonc.2025.10.024_bib0014","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.eururo.2012.11.013","article-title":"Obesity and prostate cancer: weighing the evidence","volume":"63","author":"Allott","year":"2013","journal-title":"Eur Urol"},{"issue":"10","key":"10.1016\/j.urolonc.2025.10.024_bib0015","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1158\/1055-9965.1646.13.10","article-title":"Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study","volume":"13","author":"Laukkanen","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"10.1016\/j.urolonc.2025.10.024_bib0016","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/01.ju.0000152408.25738.23","article-title":"Obesity and prostate cancer clinical risk factors at presentation: data from CaPSURE","volume":"173","author":"Kane","year":"2005","journal-title":"J Urol"},{"issue":"11","key":"10.1016\/j.urolonc.2025.10.024_bib0017","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S1470-2045(08)70235-3","article-title":"Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis","volume":"9","author":"Ma","year":"2008","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.urolonc.2025.10.024_bib0018","doi-asserted-by":"crossref","first-page":"930","DOI":"10.2337\/dc07-1962","article-title":"Serum prostate-specific antigen levels in men with type 2 diabetes","volume":"31","author":"Fukui","year":"2008","journal-title":"Diabetes Care"},{"issue":"19","key":"10.1016\/j.urolonc.2025.10.024_bib0019","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1001\/jama.298.19.2275","article-title":"Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer","volume":"298","author":"Ba\u00f1ez","year":"2007","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.urolonc.2025.10.024_bib0020","article-title":"The interactions between insulin and androgens in progression to castrate-resistant prostate cancer","volume":"2012","author":"Gunter","year":"2012","journal-title":"Adv Urol"},{"issue":"2","key":"10.1016\/j.urolonc.2025.10.024_bib0021","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0022-5347(05)00162-X","article-title":"Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection","volume":"175","author":"Freedland","year":"2006","journal-title":"J Urol"},{"issue":"10","key":"10.1016\/j.urolonc.2025.10.024_bib0022","article-title":"Effect of baseline characteristics and tumor burden on Vaspin expression and progressive disease in operable colorectal cancer","volume":"10","author":"Kan","year":"2020","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"10.1016\/j.urolonc.2025.10.024_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227459","article-title":"Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)","volume":"15","author":"Pazgan-Simon","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.urolonc.2025.10.024_bib0024","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cyto.2013.02.012","article-title":"Circulating levels of novel adipocytokines in patients with colorectal cancer","volume":"62","author":"Fazeli","year":"2013","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.urolonc.2025.10.024_bib0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4161\/adip.20877","article-title":"Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines","volume":"1","author":"Seldin","year":"2012","journal-title":"Adipocyte"},{"issue":"7","key":"10.1016\/j.urolonc.2025.10.024_bib0026","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1055\/a-0896-8548","article-title":"Circulating serum myonectin levels in obesity and type 2 diabetes mellitus","volume":"129","author":"Li","year":"2021","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"1","key":"10.1016\/j.urolonc.2025.10.024_bib0027","doi-asserted-by":"crossref","first-page":"e3085","DOI":"10.1002\/dmrr.3085","article-title":"Circulating C1q\/TNF-related protein isoform 15 is a marker for the presence of metabolic syndrome","volume":"35","author":"Mi","year":"2019","journal-title":"Diabetes Metab Res Rev"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143925004442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143925004442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:31:48Z","timestamp":1773919908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143925004442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1078143925004442"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2025.10.024","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging roles of vaspin and myonectin as novel biomarkers in prostate cancer diagnosis and staging vaspin and myonectin as novel biomarkers for prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2025.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}