{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:27:21Z","timestamp":1771432041784,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.urolonc.2025.12.020","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:50:26Z","timestamp":1768211426000},"page":"110984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alopecia following single-dose postoperative intravesical gemcitabine in nonmuscle-invasive bladder cancer: A multi-institutional case series"],"prefix":"10.1016","volume":"44","author":[{"given":"Anosh","family":"Dadabhoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirag","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-3919","authenticated-orcid":false,"given":"Mazyar","family":"Zahir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanam","family":"Ladi-Seyedian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenique","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Schuckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Kates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush K.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth P.","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Chamie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Weizer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-9598","authenticated-orcid":false,"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.urolonc.2025.12.020_bib0001","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"10.1016\/j.urolonc.2025.12.020_bib0002","first-page":"507","article-title":"Bladder cancer: diagnosis and treatment","volume":"96","author":"DeGeorge","year":"2017","journal-title":"Am Fam Physician"},{"issue":"1","key":"10.1016\/j.urolonc.2025.12.020_bib0003","first-page":"15","article-title":"Epidemiology of Bladder Cancer","volume":"8","author":"Saginala","year":"2020","journal-title":"Med Sci (Basel)"},{"issue":"4","key":"10.1016\/j.urolonc.2025.12.020_bib0004","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/JU.0000000000003846","article-title":"Diagnosis and treatment of non-muscle invasive bladder cancer: AUA\/SUO guideline: 2024 amendment","volume":"211","author":"Holzbeierlein","year":"2024","journal-title":"J Urol"},{"issue":"2","key":"10.1016\/j.urolonc.2025.12.020_bib0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.eururo.2015.05.050","volume":"69","author":"Sylvester","year":"2016","journal-title":"Eur Urol"},{"issue":"29","key":"10.1016\/j.urolonc.2025.12.020_bib0006","doi-asserted-by":"crossref","first-page":"45479","DOI":"10.18632\/oncotarget.9991","article-title":"Single, immediate postoperative instillation of chemotherapy in non-muscle invasive bladder cancer: a systematic review and network meta-analysis of randomized clinical trials using different drugs","volume":"7","author":"Kang","year":"2016","journal-title":"Oncotarget"},{"issue":"18","key":"10.1016\/j.urolonc.2025.12.020_bib0007","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1001\/jama.2018.4657","article-title":"Effect of intravesical instillation of gemcitabine vs saline immediately following resection of suspected low-grade non\u2013Muscle-invasive bladder cancer on tumor recurrence: SWOG S0337 randomized clinical trial","volume":"319","author":"Messing","year":"2018","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.urolonc.2025.12.020_bib0008","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1200\/JCO.2008.20.8199","article-title":"Randomized phase III trial on gemcitabine versus mytomicin in recurrent superficial bladder cancer: evaluation of efficacy and tolerance","volume":"28","author":"Addeo","year":"2010","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.urolonc.2025.12.020_bib0009","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5455\/medarh.2022.76.198-201","article-title":"Comparison between intravesical chemotherapy Epirubicin and Mitomycin-C after TURB vs TURB alone with recurrence rate of non-muscle invasive bladder cancer: meta-analysis","volume":"76","author":"Daryanto","year":"2022","journal-title":"Med Arch"},{"issue":"3","key":"10.1016\/j.urolonc.2025.12.020_bib0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00001813-199803000-00001","article-title":"Gemcitabine\u2013a safety review","volume":"9","author":"Aapro","year":"1998","journal-title":"Anticancer Drugs"},{"issue":"2","key":"10.1016\/j.urolonc.2025.12.020_bib0011","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.ju.0000131770.14409.7f","article-title":"Phase I pharmacokinetic study of a single intravesical instillation of gemcitabine administered immediately after transurethral resection plus multiple random biopsies in patients with superficial bladder cancer","volume":"172","author":"Palou","year":"2004","journal-title":"J Urol"},{"issue":"9","key":"10.1016\/j.urolonc.2025.12.020_bib0012","first-page":"2629","article-title":"Toxicology and pharmacokinetics of intravesical gemcitabine: a preclinical study in dogs","volume":"5","author":"Cozzi","year":"1999","journal-title":"Clin Cancer Res"},{"issue":"19","key":"10.1016\/j.urolonc.2025.12.020_bib0013","first-page":"4349","article-title":"Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines","volume":"58","author":"Mackey","year":"1998","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.urolonc.2025.12.020_bib0014","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1200\/JCO.2003.09.028","article-title":"Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: a phase I and pharmacokinetic study","volume":"21","author":"Laufer","year":"2003","journal-title":"J Clin Oncol"},{"issue":"3c","key":"10.1016\/j.urolonc.2025.12.020_bib0015","first-page":"2493","article-title":"Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study","volume":"25","author":"Mattioli","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1016\/j.urolonc.2025.12.020_bib0016","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.urology.2021.04.062","article-title":"Comparison of side effects and tolerability between intravesical Bacillus Calmette-Guerin, reduced-dose BCG and gemcitabine for non-muscle invasive bladder cancer","volume":"156","author":"Kuperus","year":"2021","journal-title":"Urology"},{"issue":"26","key":"10.1016\/j.urolonc.2025.12.020_bib0017","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1056\/NEJM197912273012605","article-title":"Prevention of doxorubicin-induced hair loss with scalp hypothermia","volume":"301","author":"Dean","year":"1979","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.urolonc.2025.12.020_bib0018","first-page":"1145","article-title":"Experimental study on the toxicity and the local and systemic tolerability of gemcitabine after topical treatment of the rabbit bladder","volume":"11","author":"Matera","year":"2004","journal-title":"Oncol Rep"},{"key":"10.1016\/j.urolonc.2025.12.020_bib0019","series-title":"Handbook of hair in health and disease","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3920\/978-90-8686-728-8_20","article-title":"Chemotherapy-induced hair loss","author":"van den Hurk","year":"2012"},{"issue":"3","key":"10.1016\/j.urolonc.2025.12.020_bib0020","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.eururo.2009.06.010","article-title":"Single postoperative instillation of gemcitabine in patients with non-muscle-invasive transitional cell carcinoma of the bladder: a randomised, double-blind, placebo-controlled phase III multicentre study","volume":"56","author":"B\u00f6hle","year":"2009","journal-title":"Eur Urol"},{"issue":"6","key":"10.1016\/j.urolonc.2025.12.020_bib0021","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1177\/147323000903700618","article-title":"The effects of intravesical chemoimmunotherapy with gemcitabine and Bacillus Calmette-gu\u00e9rin in superficial bladder cancer: a preliminary study","volume":"37","author":"Cho","year":"2009","journal-title":"J Int Med Res"},{"issue":"4","key":"10.1016\/j.urolonc.2025.12.020_bib0022","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.3390\/curroncol30040275","article-title":"Prevention and treatment of chemotherapy-induced alopecia: what is available and what is coming?","volume":"30","author":"Wikramanayake","year":"2023","journal-title":"Curr Oncol"},{"issue":"33","key":"10.1016\/j.urolonc.2025.12.020_bib0023","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1200\/JCO-25-01651","article-title":"TAR-200 for bacillus calmette-gu\u00e9rin\u2013unresponsive high-risk non\u2013muscle-invasive bladder cancer: results from the phase IIb SunRISe-1 study","volume":"43","author":"Daneshmand","year":"2025","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.urolonc.2025.12.020_bib0024","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S1470-2045(25)00358-4","volume":"26","author":"Necchi","year":"2025","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.urolonc.2025.12.020_bib0025","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.urology.2009.05.094","article-title":"Systemic absorption and pharmacokinetics of single-dose intravesical gemcitabine after transurethral resection of the bladder in non-muscle-invasive bladder cancer","volume":"74","author":"Maffezzini","year":"2009","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.urolonc.2025.12.020_bib0026","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ymthe.2019.11.026","article-title":"The emerging role of cytidine deaminase in human diseases: a new opportunity for therapy?","volume":"28","author":"Frances ACordelier","year":"2020","journal-title":"Mol Ther"},{"issue":"8","key":"10.1016\/j.urolonc.2025.12.020_bib0027","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2165\/11532970-000000000-00000","article-title":"Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms","volume":"49","author":"Sugiyama","year":"2010","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"10.1016\/j.urolonc.2025.12.020_bib0028","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1200\/JCO.2006.06.7405","article-title":"Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism","volume":"25","author":"Sugiyama","year":"2007","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.urolonc.2025.12.020_bib0029","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0167-4889(96)00024-9","article-title":"Expression of cytidine deaminase in human solid tumors and its regulation by 1 alpha,25-dihydroxyvitamin D3","volume":"1312","author":"Watanabe SUchida","year":"1996","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.urolonc.2025.12.020_bib0030","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1080\/15257770802145447","article-title":"Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples","volume":"27","author":"Giovannetti","year":"2008","journal-title":"Nucleosid Nucleotid Nucl Acids"},{"issue":"6","key":"10.1016\/j.urolonc.2025.12.020_bib0031","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1158\/1078-0432.CCR-07-1364","article-title":"Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine\/cisplatin-treated advanced non-small cell lung cancer patients","volume":"14","author":"Tibaldi","year":"2008","journal-title":"Clin Cancer Res"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143925005034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078143925005034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:45:56Z","timestamp":1771429556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078143925005034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1078143925005034"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2025.12.020","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alopecia following single-dose postoperative intravesical gemcitabine in nonmuscle-invasive bladder cancer: A multi-institutional case series","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2025.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110984"}}