{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:07:22Z","timestamp":1789762042819,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.urolonc.2026.06.025","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:07:21Z","timestamp":1785697641000},"page":"767-775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term outcomes of men stratified by 4Kscore: a retrospective analysis"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-7710","authenticated-orcid":false,"given":"Omri","family":"Nativ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Guerard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cortizas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Szczotka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Cuvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archan","family":"Khandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro F.S.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivet T Cordoba","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabika","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gonzalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Ritch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Nahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipen J.","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanoj","family":"Punnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.urolonc.2026.06.025_bib0001","first-page":"10","article-title":"Cancer Statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin."},{"issue":"2","key":"10.1016\/j.urolonc.2026.06.025_bib0002","first-page":"259","article-title":"EAU - ESTRO - ESUR - SIOG guidelines on prostate cancer 2022","volume":"82","author":"Mottet","year":"2022","journal-title":"Eur Urol."},{"issue":"6","key":"10.1016\/j.urolonc.2026.06.025_bib0003","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.eururo.2013.05.049","article-title":"Systematic review of complications of prostate biopsy","volume":"64","author":"Loeb","year":"2013","journal-title":"Eur Urol."},{"issue":"2","key":"10.1016\/j.urolonc.2026.06.025_bib0004","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.juro.2013.04.119","article-title":"Early detection of prostate cancer: AUA guideline","volume":"190","author":"Carter","year":"2013","journal-title":"J Urol."},{"issue":"1","key":"10.1016\/j.urolonc.2026.06.025_bib0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eururo.2015.04.039","article-title":"Urine TMPRSS2:ERG plus PCA3 for individualized prostate cancer risk assessment","volume":"70","author":"Tomlins","year":"2016","journal-title":"Eur Urol."},{"issue":"3","key":"10.1016\/j.urolonc.2026.06.025_bib0006","first-page":"456","article-title":"Use of prostate cancer genomic classifier in clinical practice","volume":"72","author":"Tosoian","year":"2017","journal-title":"Eur Urol."},{"key":"10.1016\/j.urolonc.2026.06.025_bib0007","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1741-7015-6-19","article-title":"A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in G\u00f6teborg, Sweden","volume":"6","author":"Vickers","year":"2008","journal-title":"BMC Med."},{"issue":"3","key":"10.1016\/j.urolonc.2026.06.025_bib0008","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.eururo.2014.10.021","article-title":"A multi-institutional prospective trial in the USA confirms that the 4Kscore accurately identifies men with high-grade prostate cancer","volume":"68","author":"Parekh","year":"2015","journal-title":"Eur Urol"},{"issue":"3","key":"10.1016\/j.urolonc.2026.06.025_bib0009","first-page":"320","article-title":"Clinical validation of the 4Kscore test to detect high-grade prostate cancer in men with previous negative biopsy","volume":"20","author":"Tosoian","year":"2017","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"3","key":"10.1016\/j.urolonc.2026.06.025_bib0010","first-page":"572","article-title":"Prediction models for prostate cancer: the importance of calibration","volume":"65","author":"Vickers","year":"2014","journal-title":"Eur Urol."},{"issue":"4","key":"10.1016\/j.urolonc.2026.06.025_bib0011","first-page":"455","article-title":"The clinical utility of the 4Kscore test for prostate cancer risk stratification","volume":"47","author":"Punnen","year":"2020","journal-title":"Urol Clin North Am"},{"issue":"6","key":"10.1016\/j.urolonc.2026.06.025_bib0012","article-title":"A 10-year validation of the 4Kscore test for predicting risk of lethal prostate cancer","volume":"109","author":"Vickers","year":"2017","journal-title":"J Natl Cancer Inst."},{"issue":"1","key":"10.1016\/j.urolonc.2026.06.025_bib0013","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jama.294.1.66","article-title":"Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng\/ml or lower","volume":"294","author":"Thompson","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.urolonc.2026.06.025_bib0014","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c4521","article-title":"Prostate specific antigen concentration at age 60 and death or metastasis from prostate cancer: case-control study","volume":"341","author":"Vickers","year":"2010","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.urolonc.2026.06.025_bib0015","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/cncr.25568","article-title":"Prediction of significant prostate cancer diagnosed 20 to 30 years later with a single measure of prostate-specific antigen at or before age 50","volume":"117","author":"Lilja","year":"2011","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.urolonc.2026.06.025_bib0016","first-page":"741","article-title":"Predicting high-grade cancer at ten-core prostate biopsy using four kallikrein markers measured in blood in the ProtecT study","volume":"102","author":"Bryant","year":"2010","journal-title":"J Natl Cancer Inst."},{"issue":"4","key":"10.1016\/j.urolonc.2026.06.025_bib0017","first-page":"537","article-title":"Predictive value of the 4Kscore in men with an elevated PSA: a meta-analysis","volume":"64","author":"Carlsson","year":"2013","journal-title":"Eur Urol."},{"issue":"1","key":"10.1016\/j.urolonc.2026.06.025_bib0018","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.eururo.2014.08.010","article-title":"Comparison between the four-kallikrein panel and prostate health index for predicting prostate cancer","volume":"68","author":"Nordstr\u00f6m","year":"2015","journal-title":"Eur Urol."},{"issue":"3","key":"10.1016\/j.urolonc.2026.06.025_bib0019","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eururo.2024.04.037","article-title":"Performance of 4Kscore as a reflex test to prostate-specific antigen in the G\u00d6TEBORG-2 prostate cancer screening trial","volume":"86","author":"Josefsson","year":"2024","journal-title":"Eur Urol"},{"issue":"23","key":"10.1016\/j.urolonc.2026.06.025_bib0020","first-page":"2748","article-title":"Twenty-year risk of prostate cancer death by baseline PSA and kallikrein panel scores","volume":"34","author":"Sjoberg","year":"2016","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.urolonc.2026.06.025_bib0021","doi-asserted-by":"crossref","unstructured":"Stattin P, Vickers AJ, Sjoberg DD, et al. Improving the specificity of screening for lethal prostate cancer using prostate-specific antigen and a panel of kallikrein markers: a nested case-control study. Eur Urol. doi: 10.1016\/j.eururo.2015.01.009.","DOI":"10.1016\/j.eururo.2015.01.009"},{"issue":"3","key":"10.1016\/j.urolonc.2026.06.025_bib0022","first-page":"251","article-title":"Finding the wolf in sheep's clothing: the role of novel biomarkers in prostate cancer","volume":"25","author":"Punnen","year":"2015","journal-title":"Curr Opin Urol."},{"key":"10.1016\/j.urolonc.2026.06.025_bib0023","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.juro.2010.12.032","article-title":"A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng\/ml prostate specific antigen range","volume":"185","author":"Catalona","year":"2011","journal-title":"J Urol."},{"issue":"10071","key":"10.1016\/j.urolonc.2026.06.025_bib0024","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet."},{"issue":"11","key":"10.1016\/j.urolonc.2026.06.025_bib0025","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/j.1464-410X.2010.09761.x","article-title":"Intra-individual short-term variability of prostate-specific antigen and other kallikrein markers in a serial collection of blood from men under evaluation for prostate cancer","volume":"107","author":"Christensson","year":"2011","journal-title":"BJU Int."},{"key":"10.1016\/j.urolonc.2026.06.025_bib0026","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cca.2018.07.043","article-title":"Biological variation estimates for prostate specific antigen from the European Biological Variation Study; consequences for diagnosis and monitoring of prostate cancer","volume":"486","author":"Carobene","year":"2018","journal-title":"Clin Chim Acta."},{"issue":"11","key":"10.1016\/j.urolonc.2026.06.025_bib0027","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/jamaoncol.2025.3386","article-title":"Prostate-specific antigen levels among participants receiving annual testing","volume":"11","author":"Pickersgill","year":"2025","journal-title":"JAMA Oncol."},{"issue":"7","key":"10.1016\/j.urolonc.2026.06.025_bib0028","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/pros.23495","article-title":"The effect of digital rectal exam on the 4Kscore for aggressive prostate cancer","volume":"78","author":"Maccini","year":"2018","journal-title":"Prostate"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107814392600582X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107814392600582X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:20:36Z","timestamp":1789759236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107814392600582X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S107814392600582X"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2026.06.025","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term outcomes of men stratified by 4Kscore: a retrospective analysis","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2026.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}