{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:25:29Z","timestamp":1793805929137,"version":"4.6.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Urologic Oncology: Seminars and Original Investigations"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.urolonc.2026.07.003","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:27:00Z","timestamp":1784978820000},"page":"528-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of BRCA2 protein expression by immunohistochemistry with biochemical recurrence in localized prostate cancer treated with radiotherapy: A long-term outcome analysis"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-2371","authenticated-orcid":false,"given":"Kento","family":"Morozumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Iwamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Sawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kusumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kawamorita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kaiho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.urolonc.2026.07.003_bib0001","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.eururo.2015.11.010","article-title":"Surgery versus radiotherapy for clinically-localized prostate cancer: a systematic review and meta-analysis","volume":"70","author":"Wallis","year":"2016","journal-title":"Eur Urol"},{"issue":"13 Suppl","key":"10.1016\/j.urolonc.2026.07.003_bib0002","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1002\/cncr.24348","article-title":"Predictive models in external beam radiotherapy for clinically localized prostate cancer","volume":"115","author":"Roach","year":"2009","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.urolonc.2026.07.003_bib0003","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3390\/cancers12061550","article-title":"Clinical applications of molecular biomarkers in prostate cancer","volume":"12","author":"Cou\u00f1ago","year":"2020","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.urolonc.2026.07.003_bib0004","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.urolonc.2026.07.003_bib0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1097-2765(01)00174-5","article-title":"BRCA2 is required for homology-directed repair of chromosomal breaks","volume":"7","author":"Moynahan","year":"2001","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.urolonc.2026.07.003_bib0006","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10549-009-0685-6","article-title":"Is the breast-conserving treatment with radiotherapy appropriate in BRCA1\/2 mutation carriers? Long-term results and review of the literature","volume":"120","author":"Kirova","year":"2010","journal-title":"Breast Cancer Res Treatment"},{"issue":"14","key":"10.1016\/j.urolonc.2026.07.003_bib0007","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1200\/JCO.2012.43.1882","article-title":"Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer","volume":"31","author":"Castro","year":"2013","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.urolonc.2026.07.003_bib0008","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.eururo.2014.10.022","article-title":"Effect of BRCA mutations on metastatic relapse and cause-specific survival after radical treatment for localised prostate cancer","volume":"68","author":"Castro","year":"2015","journal-title":"Eur Urol"},{"issue":"4","key":"10.1016\/j.urolonc.2026.07.003_bib0009","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jclinpath-2019-206276","article-title":"Immunohistochemistry for the detection of BRCA1 and BRCA2 proteins in patients with ovarian cancer: a systematic review","volume":"73","author":"Teixeira","year":"2020","journal-title":"J Clin Pathol"},{"issue":"6","key":"10.1016\/j.urolonc.2026.07.003_bib0010","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.eururo.2014.09.028","article-title":"The natural history and predictors of outcome following biochemical relapse in the dose escalation era for prostate cancer patients undergoing definitive external beam radiotherapy","volume":"67","author":"Zumsteg","year":"2015","journal-title":"Eur Urol"},{"issue":"24","key":"10.1016\/j.urolonc.2026.07.003_bib0011","doi-asserted-by":"crossref","first-page":"13920","DOI":"10.1073\/pnas.96.24.13920","article-title":"Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations","volume":"96","author":"Spain","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.urolonc.2026.07.003_bib0012","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/his.12809","article-title":"Overexpression of BRCA1 or BRCA2 in prostatectomy specimens is predictive of biochemical recurrence after radical prostatectomy","volume":"68","author":"Kim","year":"2016","journal-title":"Histopathology"},{"issue":"6","key":"10.1016\/j.urolonc.2026.07.003_bib0013","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1200\/JCO.18.00358","article-title":"PROREPAIR-B: a prospective cohort study of the impact of germline DNA repair mutations on the outcomes of patients with metastatic castration-resistant prostate cancer","volume":"37","author":"Castro","year":"2019","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.urolonc.2026.07.003_bib0014","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eururo.2017.02.023","article-title":"Treatment outcomes and tumor loss of heterozygosity in germline DNA repair-deficient prostate cancer","volume":"72","author":"Annala","year":"2017","journal-title":"Eur Urol"},{"issue":"5","key":"10.1016\/j.urolonc.2026.07.003_bib0015","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA-repair gene mutations in men with metastatic prostate cancer","volume":"375","author":"Pritchard","year":"2016","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.urolonc.2026.07.003_bib0016","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/cancers15092435","article-title":"Frequency of germline and somatic BRCA1 and BRCA2 mutations in prostate cancer: an updated systematic review and meta-analysis","volume":"15","author":"Valsecchi","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.urolonc.2026.07.003_bib0017","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12301-020-00079-w","article-title":"Immunohistochemical expression of BRCA1 and BRCA2 in a cohort of Ugandan men with prostate cancer: an analytical cross-sectional study","volume":"26","author":"Amsi","year":"2020","journal-title":"Afr J Urol"},{"issue":"8","key":"10.1016\/j.urolonc.2026.07.003_bib0018","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3390\/genes12081229","article-title":"Guardians of the genome: BRCA2 and its partners","volume":"12","author":"Le","year":"2021","journal-title":"Genes"}],"container-title":["Urologic Oncology: Seminars and Original Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107814392600596X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107814392600596X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:27:22Z","timestamp":1793802442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107814392600596X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S107814392600596X"],"URL":"https:\/\/doi.org\/10.1016\/j.urolonc.2026.07.003","relation":{},"ISSN":["1078-1439"],"issn-type":[{"value":"1078-1439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of BRCA2 protein expression by immunohistochemistry with biochemical recurrence in localized prostate cancer treated with radiotherapy: A long-term outcome analysis","name":"articletitle","label":"Article Title"},{"value":"Urologic Oncology: Seminars and Original Investigations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.urolonc.2026.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}