{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:00:07Z","timestamp":1775473207036,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.vaa.2016.07.008","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T11:16:32Z","timestamp":1488366992000},"page":"803-810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adverse reactions of \u03b12-adrenoceptor agonists in cats reported in 2003\u20132013 in Finland"],"prefix":"10.1016","volume":"44","author":[{"given":"Marja R.","family":"Raekallio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmeli","family":"Happonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi M.","family":"Vainio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2016.07.008_bib1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5326\/JAAHA-MS-5690","article-title":"Severe esophageal injuries occurring after general anesthesia in two cats: case report and literature review","volume":"47","author":"Adami","year":"2011","journal-title":"J\u00a0Am Anim Hosp Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib2","first-page":"23","article-title":"Evaluation of xylazine-ketamine hydrochloride combination in the cat","volume":"50","author":"Allen","year":"1986","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.vaa.2016.07.008_bib3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/019262339302100607","article-title":"Biochemical and morphological alterations in xylazine-induced pulmonary edema","volume":"21","author":"Amouzadeh","year":"1993","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.vaa.2016.07.008_bib4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1467-2995.2010.00551.x","article-title":"Anaphylaxis and anaesthesia","volume":"37","author":"Armitage-Chan","year":"2010","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2016.07.008_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1053\/j.tcam.2010.09.007","article-title":"Feline anesthetic deaths in veterinary practice","volume":"25","author":"Brodbelt","year":"2010","journal-title":"Topics Companion Anim Med"},{"key":"10.1016\/j.vaa.2016.07.008_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1467-2995.2008.00397.x","article-title":"The risk of death: the confidential enquiry into perioperative small animal fatalities","volume":"35","author":"Brodbelt","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2016.07.008_bib7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/bja\/aem229","article-title":"Risk factors for anaesthetic-related death in cats: results from the confidential enquiry into perioperative small animal fatalities (CEPSAF)","volume":"99","author":"Brodbelt","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2016.07.008_bib8","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1136\/qshc.2002.004267","article-title":"Crisis management during anaesthesia: pulmonary oedema","volume":"14","author":"Chapman","year":"2005","journal-title":"Qual Saf Health Care"},{"key":"10.1016\/j.vaa.2016.07.008_bib9","series-title":"Veterinary Anaesthesia","first-page":"611","article-title":"Complications","author":"Clarke","year":"2014"},{"key":"10.1016\/j.vaa.2016.07.008_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/vr.g7634","article-title":"Suspected adverse events, 2013","volume":"176","author":"Davis","year":"2015","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaa.2016.07.008_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/vr.f7381","article-title":"Suspected adverse events, 2012","volume":"173","author":"Davis","year":"2013","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaa.2016.07.008_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1748-5827.1996.tb01953.x","article-title":"Cardiovascular changes associated with anaesthesia induced by medetomidine combined with ketamine in cats","volume":"37","author":"Dobromylskyj","year":"1996","journal-title":"J\u00a0Small Anim Pract"},{"key":"10.1016\/j.vaa.2016.07.008_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00128594-200404000-00011","article-title":"Pulmonary oedema secondary to dynamic tracheal collapse","volume":"11","author":"Firdose","year":"2004","journal-title":"J\u00a0Bronchology"},{"key":"10.1016\/j.vaa.2016.07.008_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1439-0442.2001.00357.x","article-title":"Gastro-oesophageal reflux during thiopentone or propofol anaesthesia in the cat","volume":"48","author":"Galatos","year":"2001","journal-title":"J\u00a0Vet Med A Physiol Pathol Clin Med"},{"key":"10.1016\/j.vaa.2016.07.008_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5326\/15473317-35-1-13","article-title":"Complications and mortality associated with anesthesia in dogs and cats","volume":"35","author":"Gaynor","year":"1999","journal-title":"J\u00a0Am Anim Hosp Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2460\/ajvr.1998.59.04.509","article-title":"Cardiovascular effects of the alpha-2-adrenergic receptor agonist medetomidine in clinically normal cats anesthetized with isoflurane","volume":"59","author":"Golden","year":"1998","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.07.008_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1467-2995.2005.00259.x","article-title":"Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole","volume":"33","author":"Granholm","year":"2006","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2016.07.008_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.rvsc.2006.11.015","article-title":"Dexmedetomidine-induced pulmonary alterations in sheep","volume":"83","author":"K\u00e4stner","year":"2006","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.vaa.2016.07.008_bib19","first-page":"207","article-title":"Pulmonary oedema secondary to upper airway obstruction in the dog, a review of nine cases","volume":"25","author":"Kerr","year":"1989","journal-title":"J\u00a0Am Anim Hosp Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib20","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2460\/javma.239.11.1453","article-title":"Evaluation of dexmedetomidine and ketamine in combination with various opioids as injectable anesthetic combinations for castration in cats","volume":"239","author":"Ko","year":"2011","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib21","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2460\/javma.1993.202.07.1116","article-title":"Pulmonary edema associated with transient airway obstruction in three horses","volume":"202","author":"Kollias-Baker","year":"1993","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/cei.12424","article-title":"Multi-centre retrospective analysis of anaphylaxis during general anaesthesia in the United Kingdom: aetiology and diagnostic performance of acute serum tryptase","volume":"178","author":"Krishna","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaa.2016.07.008_bib23","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2460\/ajvr.2001.62.1745","article-title":"Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats","volume":"62","author":"Lamont","year":"2001","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.07.008_bib24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1751-0813.2006.00067.x","article-title":"APVMA veterinary pharmacovigilance program: suspected adverse experience reports for 2005","volume":"84","author":"Linnett","year":"2006","journal-title":"Aust Vet J"},{"key":"10.1016\/j.vaa.2016.07.008_bib25","series-title":"The cat: Clinical Medicine and management","first-page":"52","article-title":"Fluid therapy","author":"Lunn","year":"2012"},{"key":"10.1016\/j.vaa.2016.07.008_bib26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2460\/javma.240.4.404","article-title":"Clinical efficacy and safety of dexmedetomidine used as a preanesthetic prior to general anesthesia in cats","volume":"240","author":"McSweeney","year":"2012","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib27","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2460\/javma.234.11.1398","article-title":"Prevalence of cardiomyopathy in apparently healthy cats","volume":"234","author":"Paige","year":"2009","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1467-2995.2011.00663.x","article-title":"Hemodynamic effects of dexmedetomidine in isoflurane-anesthetized cats","volume":"38","author":"Pypendop","year":"2011","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2016.07.008_bib29","first-page":"27","article-title":"Suspected adverse reaction to xylazine-ketamine anesthesia in a cat","volume":"21","author":"Raptopoulos","year":"1993","journal-title":"Fel Pract"},{"key":"10.1016\/j.vaa.2016.07.008_bib30","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/all.12168","article-title":"Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010","volume":"68","author":"Renaudin","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.vaa.2016.07.008_bib31","first-page":"39","article-title":"Cardiovascular actions of medetomidine and their reversal by atipamezole","volume":"85","author":"Savola","year":"1989","journal-title":"Acta Vet Scand Suppl"},{"key":"10.1016\/j.vaa.2016.07.008_bib32","first-page":"377","article-title":"Anaphylaxis in dogs and cats","volume":"23","author":"Shmuel","year":"2013","journal-title":"J\u00a0Vet Emerg Crit Care (San Antonio)"},{"key":"10.1016\/j.vaa.2016.07.008_bib33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2460\/javma.2003.222.37","article-title":"Evaluation of the sedative and cardiorespiratory effects of dexmedetomidine, dexmedetomidine\u2013butorphanol and dexmedetomidine\u2013ketamine in cats","volume":"222","author":"Selmi","year":"2003","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2016.07.008_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/01652176.1992.9694340","article-title":"Myocardial damage in cats that died after anaesthesia","volume":"15","author":"Van Der Linde-Sipman","year":"1992","journal-title":"Vet Q"},{"key":"10.1016\/j.vaa.2016.07.008_bib35","first-page":"117","article-title":"Medetomidine\/ketamine anaesthesia in cats","volume":"85","author":"Verstegen","year":"1989","journal-title":"Acta Vet Scand"},{"key":"10.1016\/j.vaa.2016.07.008_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/vr.128.3.57","article-title":"Antagonistic activities of atipamezole, 4-aminopyridine and yohimbine against medetomidine\/ketamine-induced anaesthesia in cats","volume":"128","author":"Verstegen","year":"1991","journal-title":"Vet Rec"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298717300776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298717300776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:47:42Z","timestamp":1761446862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298717300776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1467298717300776"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2016.07.008","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse reactions of \u03b12-adrenoceptor agonists in cats reported in 2003\u20132013 in Finland","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2016.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}