{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:29:35Z","timestamp":1780352975651,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.vaa.2016.11.012","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T10:49:03Z","timestamp":1490179743000},"page":"746-754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hematological and splenic Doppler ultrasonographic changes in dogs sedated with acepromazine or xylazine"],"prefix":"10.1016","volume":"44","author":[{"given":"Dienifer V.","family":"Sutil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio R.S.","family":"Mattoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Volpato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia C.","family":"Weinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1dson","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozyanne R.","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago R.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane L.","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronise","family":"Tochetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Comassetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mere E.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2016.11.012_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/vr.138.1.11","article-title":"Cardiopulmonary effects of combinations of medetomidine hydrochloride and atropine sulphate in dogs","volume":"138","author":"Alibhai","year":"1996","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaa.2016.11.012_bib2","series-title":"Goodman & Gilman's: The Pharmacological Basis of Therapeutics","first-page":"485","article-title":"Drugs and the treatment of psychiatric disorders: psychosis and mania","author":"Baldessarini","year":"2001"},{"key":"10.1016\/j.vaa.2016.11.012_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2885.1982.tb00495.x","article-title":"The pharmacokinetics, pharmacological responses and behavioral effects of acepromazine in the horse","volume":"5","author":"Ballard","year":"1982","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2016.11.012_bib4","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/hep.510230515","article-title":"Splenic Doppler impedance indices: influence of different portal hemodynamic conditions","volume":"23","author":"Bolognesi","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.vaa.2016.11.012_bib5","series-title":"Interpretation of Laboratory Results for Clinicians of Small Animals","first-page":"376","author":"Bush","year":"2004"},{"key":"10.1016\/j.vaa.2016.11.012_bib6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2460\/ajvr.2004.65.909","article-title":"Assessment of repeatability, reproducibility, and effect of anesthesia on determination of radial and longitudinal left ventricular velocities via tissue Doppler imaging in dogs","volume":"65","author":"Chetboul","year":"2004","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.11.012_bib7","series-title":"Anestesia em c\u00e3es e gatos","first-page":"217","article-title":"Preanesthetic medication","author":"Cortopassi","year":"2010"},{"key":"10.1016\/j.vaa.2016.11.012_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/vaa.12009","article-title":"Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses","volume":"40","author":"Deniau","year":"2013","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2016.11.012_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0749-0739(17)30389-9","article-title":"Sedatives, tranquilizers, and stimulants","volume":"9","author":"Dyke","year":"1993","journal-title":"Vet Clin North Am Equine Pract"},{"key":"10.1016\/j.vaa.2016.11.012_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5326\/15473317-34-4-325","article-title":"Morbidity and mortality associated with anesthetic management in small animal veterinary practice in Ontario","volume":"34","author":"Dyson","year":"1998","journal-title":"J\u00a0Am Anim Hosp Assoc"},{"key":"10.1016\/j.vaa.2016.11.012_bib11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2460\/ajvr.1986.47.03.631","article-title":"Cardiopulmonary effects of acepromazine and of the subsequent administration of ketamine in the dog","volume":"47","author":"Farver","year":"1986","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.11.012_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3923\/ijp.2009.76.80","article-title":"Effect of xylazine sedation on some haematological indices after chloramphenicol pre-treatment in Sokoto red goats","volume":"5","author":"Gweba","year":"2009","journal-title":"Int J Pharmacol"},{"key":"10.1016\/j.vaa.2016.11.012_bib13","series-title":"Textbook of Medical Physiology","first-page":"307","article-title":"Urine formation by the kidneys: I. Glomerular filtration, renal blood flow, and their control","author":"Guyton","year":"2006"},{"key":"10.1016\/j.vaa.2016.11.012_bib14","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.2460\/ajvr.1994.55.11.1570","article-title":"Effect of phenylephrine on hemodynamics and splenic dimensions in horses","volume":"55","author":"Hardy","year":"1994","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.11.012_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jcu.1870190106","article-title":"Sonographic assessment and grading of spleen size","volume":"19","author":"Ishibashi","year":"1991","journal-title":"J\u00a0Clin Ultrasound"},{"key":"10.1016\/j.vaa.2016.11.012_bib16","series-title":"Essentials of Veterinary Hematology","first-page":"3","article-title":"Examination of the blood and bone marrow","author":"Jain","year":"1993"},{"key":"10.1016\/j.vaa.2016.11.012_bib17","first-page":"334","article-title":"Effects of xylazine, romifidine or detomidine on hematology, biochemistry and splenic thickness in healthy horses","volume":"55","author":"Kullmann","year":"2014","journal-title":"Can Vet J"},{"key":"10.1016\/j.vaa.2016.11.012_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/vr.105.17.397","article-title":"Acetylpromazine administration: its effect on canine haematology","volume":"105","author":"Lang","year":"1979","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaa.2016.11.012_bib19","first-page":"203","article-title":"Influence of isoflurane anesthesia on pulsatility index and peak systolic velocity of basilar artery in dogs by Doppler ultrasonography","volume":"3","author":"Lee","year":"2002","journal-title":"J\u00a0Vet Sci"},{"key":"10.1016\/j.vaa.2016.11.012_bib20","series-title":"Lumb & Jones\u2019 Veterinary Anesthesia and Analgesia","first-page":"203","article-title":"Anticholinergics and sedation","author":"Lemke","year":"2007"},{"issue":"Suppl","key":"10.1016\/j.vaa.2016.11.012_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.2042-3306.2011.00376.x","article-title":"Nephrosplenic entrapment of the large colon in 142 horses (2000\u20132009): analysis of factors associated with decision of treatment and short-term survival","volume":"43","author":"Lindegaard","year":"2011","journal-title":"Equine Vet J"},{"key":"10.1016\/j.vaa.2016.11.012_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5326\/15473317-36-4-289","article-title":"The buccal mucosal bleeding time","volume":"36","author":"Marks","year":"2000","journal-title":"J\u00a0Am Anim Hosp Assoc"},{"key":"10.1016\/j.vaa.2016.11.012_bib23","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.2460\/ajvr.1979.40.11.1518","article-title":"Hemodynamic and respiratory effects of a xylazine-acetylpromazine drug combination in horses","volume":"40","author":"Muir","year":"1979","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.11.012_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1740-8261.2004.04039.x","article-title":"Sonographc features of drug-induced splenic congestion","volume":"45","author":"O'Brien","year":"2004","journal-title":"Vet Radiol Ultrasound"},{"key":"10.1016\/j.vaa.2016.11.012_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2885.1983.tb00388.x","article-title":"Influence of acepromazine maleate on the equine haematocrit","volume":"6","author":"Parry","year":"1983","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2016.11.012_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4322\/rbcv.2014.049","article-title":"Use of acepromazine, dexmedetomidine and xylazine in sedation in dogs: hematological and biochemical alterations","volume":"20","author":"Picioli","year":"2013","journal-title":"R\u00a0Bras Ci Vet"},{"key":"10.1016\/j.vaa.2016.11.012_bib27","first-page":"224","article-title":"Diuretic effects of medetomidine compared with xylazine in healthy dogs","volume":"73","author":"Talukder","year":"2009","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.vaa.2016.11.012_bib28","series-title":"Lumb & Jones\u2019 Veterinary Anesthesia and Analgesia","first-page":"183","article-title":"Preanesthetics and anesthetic adjuncts","author":"Thurmon","year":"1996"},{"key":"10.1016\/j.vaa.2016.11.012_bib29","series-title":"Ultrassonografia Doppler em pequenos animais","first-page":"52","article-title":"Doppler ultrasonography of the spleen","author":"Tilde","year":"2009"},{"key":"10.1016\/j.vaa.2016.11.012_bib30","first-page":"213","article-title":"Anesthetic, physiologic and hematologic effects of three pentobarbitone drug combinations in rabbits","volume":"7","author":"Udegbunam","year":"2012","journal-title":"J\u00a0Pharmacol Toxicol"},{"key":"10.1016\/j.vaa.2016.11.012_bib31","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2460\/ajvr.1991.52.05.651","article-title":"Cardiovascular\u00a0effects of xylazine and detomidine in horses","volume":"52","author":"Wagner","year":"1991","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2016.11.012_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1467-2987.2004.00152.x","article-title":"The effect of four anesthetic protocols on splenic size in dogs","volume":"31","author":"Wilson","year":"2004","journal-title":"Vet Anaesth Analg"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298717301459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298717301459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:48:40Z","timestamp":1761446920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298717301459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1467298717301459"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2016.11.012","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hematological and splenic Doppler ultrasonographic changes in dogs sedated with acepromazine or xylazine","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2016.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}