{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:30:13Z","timestamp":1776468613863,"version":"3.51.2"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.vaa.2019.03.001","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T14:24:26Z","timestamp":1553178266000},"page":"429-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of three doses of nalbuphine on reversal of sedation and cardiopulmonary effects of morphine\u2013acepromazine in healthy dogs"],"prefix":"10.1016","volume":"46","author":[{"given":"Viviane H.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myla CB.","family":"Barcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00ednia CT.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raiane A.","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline B.","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta FA.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2019.03.001_bib1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/BF03006539","article-title":"Side effects of nalbuphine while reversing opioid-induced respiratory depression: report of four cases","volume":"37","author":"Blaise","year":"1990","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.vaa.2019.03.001_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2885.2012.01409.x","article-title":"Naloxone reversal of an overdose of a novel, long-acting transdermal fentanyl solution in laboratory Beagles","volume":"35","author":"Freise","year":"2012","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2019.03.001_bib3","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1590\/S0103-84782011005000102","article-title":"Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs","volume":"41","author":"Gomes","year":"2011","journal-title":"Ci\u00eancia Rural"},{"key":"10.1016\/j.vaa.2019.03.001_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.vaa.2017.08.003","article-title":"Comparison of the sedative effects of nalbuphine and butorphanol, alone or in combination with acepromazine in dogs","volume":"45","author":"Gomes","year":"2018","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2019.03.001_bib5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2885.2007.00911.x","article-title":"Comparison of plasma histamine levels after intravenous administration of hydromorphone and morphine in dogs","volume":"30","author":"Guedes","year":"2007","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2019.03.001_bib6","series-title":"Veterinary Anaesthesia","first-page":"75","article-title":"Principles of sedation, analgesia and premedication","author":"Hall","year":"2001"},{"key":"10.1016\/j.vaa.2019.03.001_bib7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/vaa.12343","article-title":"Nalbuphine and butorphanol reverse opioid-induced respiratory depression but increase arousal in etorphine-immobilized goats (Capra hircus)","volume":"43","author":"Haw","year":"2016","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2019.03.001_bib8","series-title":"Lumb & Jones\u2019 Veterinary Anesthesia and Analgesia","first-page":"207","article-title":"Opioids","author":"KuKanich","year":"2015"},{"key":"10.1016\/j.vaa.2019.03.001_bib9","first-page":"27","article-title":"The sedative and behavioral effects of nalbuphine in dogs","volume":"42","author":"Lester","year":"2003","journal-title":"Contemp Top Lab Anim Sci"},{"key":"10.1016\/j.vaa.2019.03.001_bib10","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2460\/ajvr.1983.44.06.996","article-title":"Blood pressure response to phenylephrine infusion in halothane-anesthetized dogs given acetylpromazine maleate","volume":"44","author":"Ludders","year":"1983","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2019.03.001_bib11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2885.2008.01042.x","article-title":"Comparison of the cardio-respiratory effects of methadone and morphine in conscious dogs","volume":"32","author":"Maiante","year":"2009","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2019.03.001_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF03005476","article-title":"Narcotic reversal in hypercapnic dogs: comparison of naloxone and nalbuphine","volume":"37","author":"Mills","year":"1990","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.vaa.2019.03.001_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1467-2995.2008.00424.x","article-title":"Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine in dogs","volume":"36","author":"Monteiro","year":"2009","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2019.03.001_bib14","series-title":"Handbook of Veterinary Pain Management","first-page":"142","article-title":"Drugs used to treat pain","author":"Muir","year":"2002"},{"key":"10.1016\/j.vaa.2019.03.001_bib15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00000542-198212000-00010","article-title":"The enflurane sparing effect of morphine, butorphanol, and nalbuphine","volume":"57","author":"Murphy","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1016\/j.vaa.2019.03.001_bib16","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/clpt.1980.67","article-title":"Ceiling effect for respiratory depression by nalbuphine","volume":"27","author":"Romagnoli","year":"1980","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.vaa.2019.03.001_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2460\/ajvr.72.6.736","article-title":"Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis)","volume":"72","author":"Sanchez-Migallon Guzman","year":"2011","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2019.03.001_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0376-8716(85)90066-3","article-title":"Nalbuphine","volume":"14","author":"Schmidt","year":"1985","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.vaa.2019.03.001_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1467-2995.2004.00128.x","article-title":"Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs","volume":"31","author":"Valverde","year":"2004","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2019.03.001_bib20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1213\/00000539-198709000-00013","article-title":"Respiratory effects of nalbuphine and butorphanol in anesthetized patients","volume":"66","author":"Zucker","year":"1987","journal-title":"Anesth Analg"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298719300534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298719300534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:56:47Z","timestamp":1761447407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298719300534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1467298719300534"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2019.03.001","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of three doses of nalbuphine on reversal of sedation and cardiopulmonary effects of morphine\u2013acepromazine in healthy dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2019.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}