{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:30:20Z","timestamp":1781850620223,"version":"3.54.5"},"reference-count":10,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.vaa.2019.05.003","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T10:55:45Z","timestamp":1559991345000},"page":"815-819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of the sedative effects of medetomidine administered intranasally, by atomization or drops, and intramuscular injection in dogs"],"prefix":"10.1016","volume":"46","author":[{"given":"Majid","family":"Jafarbeglou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Marjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2019.05.003_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1748-5827.1989.tb01575.x","article-title":"Medetomidine, a new sedative-analgesic for use in the dog and its reversal with atipamezole","volume":"30","author":"Clarke","year":"1989","journal-title":"J\u00a0Small Anim Pract"},{"key":"10.1016\/j.vaa.2019.05.003_bib2","first-page":"321","article-title":"A\u00a0pharmacokinetic study of midazolam in dogs: nasal drop vs. atomizer administration","volume":"20","author":"Henry","year":"1998","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.vaa.2019.05.003_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jveb.2012.10.004","article-title":"The use of oral transmucosal detomidine hydrochloride gel to facilitate handling in dogs","volume":"8","author":"Hopfensperger","year":"2013","journal-title":"J\u00a0Vet Behav Clin Appl Res"},{"key":"10.1016\/j.vaa.2019.05.003_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2885.2000.00245.x","article-title":"Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs","volume":"23","author":"Kuusela","year":"2000","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2019.05.003_bib5","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.2460\/javma.1999.214.09.1336","article-title":"Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States","volume":"214","author":"Lund","year":"1999","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2019.05.003_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.vaa.2016.08.009","article-title":"Sedative and cardiovascular effects of intranasal or intramuscular dexmedetomidine in healthy dogs","volume":"44","author":"Micieli","year":"2017","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2019.05.003_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2885.2010.01186.x","article-title":"Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs","volume":"34","author":"Musulin","year":"2011","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2019.05.003_bib8","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1517\/17425247.2013.790887","article-title":"Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood\u2013brain barrier: an excellent platform for brain targeting","volume":"10","author":"Pardeshi","year":"2013","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.vaa.2019.05.003_bib9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2460\/javma.2001.218.1101","article-title":"Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs","volume":"218","author":"Smith","year":"2001","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2019.05.003_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ajem.2017.03.021","article-title":"Sedation effects of intranasal dexmedetomidine delivered as sprays versus drops on pediatric response to venous cannulation","volume":"35","author":"Xie","year":"2017","journal-title":"Am J Emerg Med"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298719301242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298719301242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:56:55Z","timestamp":1761447415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298719301242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1467298719301242"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2019.05.003","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the sedative effects of medetomidine administered intranasally, by atomization or drops, and intramuscular injection in dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2019.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}