{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:44:35Z","timestamp":1792813475358,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010977","name":"Vetcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.vaa.2020.08.012","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T20:26:46Z","timestamp":1614025606000},"page":"372-379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of vatinoxan on medetomidine\u2013ketamine\u2013midazolam immobilization in Patagonian maras (Dolichotis patagonum)"],"prefix":"10.1016","volume":"48","author":[{"given":"Eva M.","family":"Greunz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafne","family":"Lim\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune L.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja R.","family":"Raekallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Gr\u00f8ndahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads F.","family":"Bertelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2020.08.012_bib1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2460\/ajvr.79.9.921","article-title":"Effects of the peripherally acting \u03b12-adrenoceptor antagonist MK-467 on cardiopulmonary function in sheep sedated by intramuscular administration of medetomidine and ketamine and reversed by intramuscular administration of atipamezole","volume":"79","author":"Adam","year":"2018","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2020.08.012_bib2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.vaa.2018.06.009","article-title":"Sedative effect of intramuscular medetomidine with and without vatinoxan (MK-467), and its reversal with atipamezole in sheep","volume":"45","author":"Adam","year":"2018","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2020.08.012_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-1838(82)90035-2","article-title":"Effects of ketamine and althesin anesthesia on baroreceptor-heart rate reflex and hemodynamics of intact and pontine rabbits","volume":"5","author":"Blake","year":"1982","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.vaa.2020.08.012_bib4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1365-201x.2000.00713.x","article-title":"Near-infrared spectroscopy for monitoring muscle oxygenation","volume":"168","author":"Boushel","year":"2000","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.vaa.2020.08.012_bib5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0022-3565(25)22301-1","article-title":"A\u00a0peripherally acting alpha-2 adrenoceptor antagonist: L-659,066","volume":"425","author":"Clineschmidt","year":"1988","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.vaa.2020.08.012_bib6","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1097\/00000542-199206000-00013","article-title":"A\u00a0hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats","volume":"76","author":"Correa-Sales","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.vaa.2020.08.012_bib7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0007-1935(96)80005-4","article-title":"Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose","volume":"152","author":"Cullen","year":"1996","journal-title":"Br Vet J"},{"key":"10.1016\/j.vaa.2020.08.012_bib8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.resp.2013.01.012","article-title":"Estimated contribution of hemoglobin and myoglobin to near infrared spectroscopy","volume":"186","author":"Davis","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.vaa.2020.08.012_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00000542-198907000-00014","article-title":"Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors","volume":"71","author":"Doze","year":"1989","journal-title":"Anesthesiology"},{"key":"10.1016\/j.vaa.2020.08.012_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/bjaed\/mkw012","article-title":"Physiology of oxygen transport","volume":"16","author":"Dunn","year":"2016","journal-title":"BJA Educ"},{"key":"10.1016\/j.vaa.2020.08.012_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12878-017-0093-9","article-title":"A\u00a0comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia","volume":"17","author":"Enawgaw","year":"2017","journal-title":"BMC Hematol"},{"key":"10.1016\/j.vaa.2020.08.012_bib12","first-page":"23","article-title":"Is measurement of end-tidal\u00a0CO2 through a nasal cannula reliable?","volume":"44","author":"Fukuda","year":"1997","journal-title":"Anesth Prog"},{"key":"10.1016\/j.vaa.2020.08.012_bib13","series-title":"Veterinary Anaesthesia and Analgesia: The fifth edition of Lumb and Jones","first-page":"86","article-title":"Monitoring anesthetized patients","author":"Haskins","year":"2015"},{"key":"10.1016\/j.vaa.2020.08.012_bib14","series-title":"Ferrets, rabbits, and rodents. Clinical medicine and surgery","first-page":"429","article-title":"Anesthesia, analgesia, and sedation of small mammals","author":"Hawkins","year":"2012"},{"key":"10.1016\/j.vaa.2020.08.012_bib15","series-title":"Zoo animal and wildlife immobilization and anesthesia","first-page":"893","article-title":"Rodents","author":"Heard","year":"2014"},{"key":"10.1016\/j.vaa.2020.08.012_bib16","doi-asserted-by":"crossref","first-page":"R398","DOI":"10.1152\/ajpregu.00270.2015","article-title":"Hypoxemia, oxygen content, and the regulation of cerebral blood flow","volume":"310","author":"Hoiland","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.vaa.2020.08.012_bib17","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2885.2010.01242.x","article-title":"The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs","volume":"34","author":"Honkavaara","year":"2011","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.vaa.2020.08.012_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.vaa.2016.08.011","article-title":"The impact of MK-467 on sedation, heart rate and arterial blood pressure after intramuscular coadministration with dexmedetomidine in conscious cats","volume":"44","author":"Honkavaara","year":"2017","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2020.08.012_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.vaa.2018.01.008","article-title":"Peripheral \u03b12-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs","volume":"45","author":"Kallio-Kujala","year":"2018","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2020.08.012_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tvjl.2018.08.007","article-title":"Peripherally acting \u03b1-adrenoceptor antagonist MK-467 with intramuscular medetomidine and butorphanol in dogs: A prospective, randomised, clinical trial","volume":"240","author":"Kallio-Kujala","year":"2018","journal-title":"Vet J"},{"key":"10.1016\/j.vaa.2020.08.012_bib21","series-title":"Dukes\u2019 physiology of domestic animals","first-page":"341","article-title":"Regulation of the heart","author":"Kline","year":"2015"},{"key":"10.1016\/j.vaa.2020.08.012_bib22","first-page":"51","article-title":"Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation","volume":"8","author":"Ko","year":"2007","journal-title":"Vet Ther"},{"key":"10.1016\/j.vaa.2020.08.012_bib23","series-title":"Anaesthesia of exotic pets. London, UK","first-page":"59","article-title":"Rodent anaesthesia","author":"Longley","year":"2008"},{"key":"10.1016\/j.vaa.2020.08.012_bib24","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/bja\/47.11.1141","article-title":"Effects of ketamine on central sympathetic discharge and the baroreceptor reflex during mechanical ventilation","volume":"47","author":"McGrath","year":"1975","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2020.08.012_bib25","series-title":"The design of mammals: A scaling approach","first-page":"91","article-title":"Circulatory system","author":"Prothero","year":"2015"},{"key":"10.1016\/j.vaa.2020.08.012_bib26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1532-950X.1998.tb00539.x","article-title":"Hemodynamic effects of medetomidine in the dog: a dose titration study","volume":"27","author":"Pypendop","year":"1998","journal-title":"Vet Surg"},{"key":"10.1016\/j.vaa.2020.08.012_bib28","series-title":"Veterinary Anesthesia and Analgesia: The fifth edition of Lumb and Jones","first-page":"196","article-title":"Sedatives and tranquilizers","author":"Rankin","year":"2015"},{"key":"10.1016\/j.vaa.2020.08.012_bib29","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1111\/vaa.12058","article-title":"Effect of MK-467 on organ blood flow parameters detected by contrast-enhanced ultrasound in dogs treated with dexmedetomidine","volume":"40","author":"Restitutti","year":"2013","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2020.08.012_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.vaa.2016.04.006","article-title":"Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs","volume":"44","author":"Restitutti","year":"2017","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2020.08.012_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1638\/2018-0030","article-title":"Intravenous vatinoxan in markhors (Capra falconeri heptneri) immobilized with intramuscular medetomidine and ketamine \u2013 a preliminary dose screening study","volume":"50","author":"Sainmaa","year":"2019","journal-title":"J\u00a0Zoo Wildl Med"},{"key":"10.1016\/j.vaa.2020.08.012_bib32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/bja\/73.3.384","article-title":"Effects of midazolam and flumazenil on carotid sinus baroreflex control of circulation in rabbits","volume":"73","author":"Sakamoto","year":"1994","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2020.08.012_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cobeha.2016.11.002","article-title":"Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models of individualized clinical outcomes","volume":"14","author":"Saland","year":"2017","journal-title":"Curr Opin Behav Sci"},{"key":"10.1016\/j.vaa.2020.08.012_bib34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/vaa.12158","article-title":"The cardiopulmonary effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in dogs sedated with a combination of medetomidine and butorphanol","volume":"41","author":"Salla","year":"2014","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2020.08.012_bib35","first-page":"885","article-title":"A\u00a0review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice","volume":"44","author":"Sinclair","year":"2003","journal-title":"Can Vet J"},{"key":"10.1016\/j.vaa.2020.08.012_bib36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2460\/ajvr.79.4.376","article-title":"Effects of MK-467 hydrochloride and hyoscine butylbromide on cardiorespiratory and gastrointestinal changes induced by detomidine hydrochloride in horses","volume":"79","author":"Tapio","year":"2018","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaa.2020.08.012_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0883-9441(96)90016-7","article-title":"Effect of alpha-adrenoceptor stimulation on the diaphragmatic oxygen delivery-consumption relationship","volume":"11","author":"Ward","year":"1996","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.vaa.2020.08.012_bib38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10877-005-1655-0","article-title":"Reliability of near-infrared spectroscopy in people with dark skin pigmentation","volume":"19","author":"Wassenaar","year":"2005","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.vaa.2020.08.012_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/01652176.1994.9694406","article-title":"Sedation of wild boar (Sus scrofa) and red deer (Cervus elaphus) with medetomidine and the influence on some haematological and serum biochemical variables","volume":"16","author":"Wolkers","year":"1994","journal-title":"Vet Q"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298721000416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298721000416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:58:32Z","timestamp":1761447512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298721000416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S1467298721000416"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2020.08.012","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of vatinoxan on medetomidine\u2013ketamine\u2013midazolam immobilization in Patagonian maras (Dolichotis patagonum)","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2020.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}