{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:15:11Z","timestamp":1776154511103,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.vaa.2021.02.008","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:16:29Z","timestamp":1622592989000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the ability of haemodynamic variables obtained with minimally invasive techniques to assess fluid responsiveness in endotoxaemic Beagles"],"prefix":"10.1016","volume":"48","author":[{"given":"Melanie B.","family":"Muehlestein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Steblaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola B.","family":"Joerger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Briganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette P.N.","family":"Kutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaa.2021.02.008_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13054-015-0970-1","article-title":"A\u00a0positive fluid balance is an independent prognostic factor in patients with sepsis","volume":"19","author":"Acheampong","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.vaa.2021.02.008_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1442-2026.2001.00176.x","article-title":"Pulse rate over pressure evaluation (ROPE) is useful in the assessment of compensated haemorrhagic shock","volume":"13","author":"Ardagh","year":"2001","journal-title":"Emerg Med (Fremantle)"},{"key":"10.1016\/j.vaa.2021.02.008_bib3","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1097\/CCM.0000000000002554","article-title":"Incorporating dynamic assessment of fluid responsiveness into goal-directed therapy: a systematic review and meta-analysis","volume":"45","author":"Bednarczyk","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5811\/westjem.2012.8.11546","article-title":"Shock index and early recognition of sepsis in the emergency department: pilot study","volume":"14","author":"Berger","year":"2013","journal-title":"West J Emerg Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/bja\/aei116","article-title":"Pulse pressure and stroke volume variations during severe haemorrhage in ventilated dogs","volume":"94","author":"Berkenstadt","year":"2005","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2021.02.008_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ajem.2005.02.029","article-title":"Shock index in diagnosing early acute hypovolemia","volume":"23","author":"Birkhahn","year":"2005","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib7","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1164\/rccm.201801-0064OC","article-title":"Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia","volume":"198","author":"Byrne","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/TA.0b013e318253b52e","article-title":"Validation of the pulse rate over pressure evaluation index as a detector of early occult hemorrhage: a prospective observational study","volume":"73","author":"Campbell","year":"2012","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.vaa.2021.02.008_bib9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/jsap.12362","article-title":"Evaluation of an oesophageal Doppler device for monitoring cardiac output in anaesthetised healthy normotensive dogs","volume":"56","author":"Canfr\u00e1n","year":"2015","journal-title":"J\u00a0Small Anim Pract"},{"key":"10.1016\/j.vaa.2021.02.008_bib10","doi-asserted-by":"crossref","first-page":"H500","DOI":"10.1152\/ajpheart.1998.274.2.H500","article-title":"Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans","volume":"274","author":"Chemla","year":"1998","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.vaa.2021.02.008_bib11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.vaa.2019.08.014","article-title":"Evaluation of transesophageal Doppler in Beagle dogs as an aid to provide goal directed fluid therapy","volume":"46","author":"Chohan","year":"2019","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.02.008_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jvim.15932","article-title":"Quantification of cerebrospinal fluid flow in dogs by cardiac-gated phase-contrast magnetic resonance imaging","volume":"35","author":"Christen","year":"2021","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib13","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1097\/CCM.0000000000003522","article-title":"Esophageal Doppler can predict fluid responsiveness through end-expiratory and end-inspiratory occlusion tests","volume":"47","author":"D\u00e9pret","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib14","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.vaa.2016.11.011","article-title":"Pulse pressure variation as a guide for volume expansion in dogs undergoing orthopedic surgery","volume":"44","author":"Fantoni","year":"2017","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.02.008_bib15","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/ajplegacy.1932.99.3.534","article-title":"Studies on the circulation","volume":"99","author":"Hamilton","year":"1932","journal-title":"Am J Physiol"},{"key":"10.1016\/j.vaa.2021.02.008_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/SHK.0000000000000268","article-title":"Fluid overload in patients with severe sepsis and septic shock treated with early goal-directed therapy is associated with increased acute need for fluid-related medical interventions and hospital death","volume":"43","author":"Kelm","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.vaa.2021.02.008_bib17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/01.CCM.0000114996.68110.C9","article-title":"Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects","volume":"32","author":"Kumar","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/0885066609340640","article-title":"Techniques for assessment of intravascular volume in critically ill patients","volume":"24","author":"Marik","year":"2009","journal-title":"J\u00a0Intensive Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/bja\/aev349","article-title":"A\u00a0rational approach to fluid therapy in sepsis","volume":"116","author":"Marik","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.vaa.2021.02.008_bib20","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1097\/CCM.0b013e31828a25fd","article-title":"Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense","volume":"41","author":"Marik","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib21","first-page":"246","article-title":"Optimizing fluid therapy in shock","volume":"25","author":"Marik","year":"2019","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.vaa.2021.02.008_bib22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1164\/ajrccm.162.1.9903035","article-title":"Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure","volume":"162","author":"Michard","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10877-015-9806-4","article-title":"Transesophageal Doppler reliably tracks changes in cardiac output in comparison with intermittent pulmonary artery thermodilution in cardiac surgery patients","volume":"31","author":"M\u00f8ller-S\u00f8rensen","year":"2017","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.vaa.2021.02.008_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13613-018-0400-z","article-title":"My patient has received fluid. How to assess its efficacy and side effects?","volume":"8","author":"Monnet","year":"2018","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.vaa.2021.02.008_bib25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2460\/javma.245.9.1021","article-title":"Arterial blood pressure as a predictor of the response to fluid administration in euvolemic nonhypotensive or hypotensive isoflurane-anesthetized dogs","volume":"245","author":"Muir","year":"2014","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.vaa.2021.02.008_bib26","first-page":"545","article-title":"Assessment of shock index in healthy dogs and dogs in hemorrhagic shock","volume":"23","author":"Peterson","year":"2013","journal-title":"J\u00a0Vet Emerg Crit Care"},{"key":"10.1016\/j.vaa.2021.02.008_bib27","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/TA.0b013e31828c3565","article-title":"The pulse pressure\/heart rate ratio as a marker of stroke volume changes during hemorrhagic shock and resuscitation in anesthetized swine","volume":"74","author":"Pottecher","year":"2013","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.vaa.2021.02.008_bib28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jamcollsurg.2019.03.021","article-title":"Pulse pressure as an early warning of hemorrhage in trauma patients","volume":"229","author":"Priestley","year":"2019","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.vaa.2021.02.008_bib29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.vaa.2016.11.014","article-title":"Ability of pulse wave transit time to detect changes in stroke volume and to estimate cardiac output compared to thermodilution technique in isoflurane-anaesthetised dogs","volume":"44","author":"Sano","year":"2017","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.vaa.2021.02.008_bib31","first-page":"391","article-title":"Investigation of percentage changes in pulse wave transit time induced by mini-fluid challenges to predict fluid responsiveness in ventilated dogs","volume":"29","author":"Sano","year":"2019","journal-title":"J\u00a0Vet Emerg Crit Care"},{"key":"10.1016\/j.vaa.2021.02.008_bib32","first-page":"244","article-title":"Oesophageal Doppler","volume":"15","author":"Singer","year":"2009","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.vaa.2021.02.008_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1113\/jphysiol.1897.sp000684","article-title":"Researches on the circulation time and on the influences which affect it","volume":"22","author":"Stewart","year":"1897","journal-title":"The Journal of physiology"},{"key":"10.1016\/j.vaa.2021.02.008_bib34","first-page":"2853","article-title":"A\u00a0novel continuous cardiac output monitor based on pulse wave transit time","volume":"2010","author":"Sugo","year":"2010","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.vaa.2021.02.008_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00024382-200006000-00001","article-title":"Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene","volume":"13","author":"Taylor","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.vaa.2021.02.008_bib36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s001340000795","article-title":"Are transoesophageal Doppler parameters a reliable guide to paediatric haemodynamic status and fluid management?","volume":"27","author":"Tibby","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.vaa.2021.02.008_bib37","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/MAJ.0000000000000444","article-title":"Utility of the shock index in patients with sepsis","volume":"349","author":"Tseng","year":"2015","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.vaa.2021.02.008_bib38","first-page":"284","article-title":"Low pulse pressure as a predictor of death in patients with mild to advanced heart failure","volume":"37","author":"Yildiran","year":"2010","journal-title":"Tex Heart Inst J"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S146729872100101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S146729872100101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:59:27Z","timestamp":1761447567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S146729872100101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S146729872100101X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaa.2021.02.008","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the ability of haemodynamic variables obtained with minimally invasive techniques to assess fluid responsiveness in endotoxaemic Beagles","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaa.2021.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}